INT61624

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Context Info
Confidence 0.56
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 50
Total Number 51
Disease Relevance 33.07
Pain Relevance 13.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
macrophages 7
B cells 6
NK cell 6
T cells 5
J558 4
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1208 100.00 Very High Very High Very High
Inflammation 725 100.00 Very High Very High Very High
cINOD 22 99.98 Very High Very High Very High
Enkephalin 6 99.40 Very High Very High Very High
Neuritis 22 99.30 Very High Very High Very High
agonist 53 99.28 Very High Very High Very High
Inflammatory response 53 98.88 Very High Very High Very High
beta blocker 1 98.74 Very High Very High Very High
rheumatoid arthritis 387 98.04 Very High Very High Very High
Sciatic nerve 4 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 808 100.00 Very High Very High Very High
Cancer 644 99.92 Very High Very High Very High
Infection 326 99.72 Very High Very High Very High
Necrosis 41 99.68 Very High Very High Very High
Hepatitis C Virus Infection 119 99.52 Very High Very High Very High
Opiate Addiction 79 99.34 Very High Very High Very High
Experimental Autoimmune Neuritis 22 99.30 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 20 99.04 Very High Very High Very High
Adenocarcinoma 305 99.02 Very High Very High Very High
Carcinoma 71 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We unexpectedly found that the induction of IL-12 and TNF-alpha by these HA preparations was not due to their degradation to low-molecular-weight fragments, since their native high-molecular-weight forms possessed the same ability to stimulate IL-12 and TNF-alpha synthesis, but was due to the presence of contaminating DNA.
Positive_regulation (stimulate) of Gene_expression (synthesis) of IL-12
1) Confidence 0.56 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.74 Pain Relevance 0.49
We found that two of the seven HA preparations tested stimulated the synthesis of IL-12 and TNF-alpha by human monocytic cells.
Positive_regulation (stimulated) of Gene_expression (synthesis) of IL-12
2) Confidence 0.56 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.66 Pain Relevance 0.43
We tested low-molecular-weight fragments obtained from seven different HA preparations, either by sonication (approximately equals 3 x 10(5) Da) or by hyaluronidase digestion (approximately equals 1 x 10(4) Da), for the ability to induce the synthesis of IL-12 and TNF-alpha by human monocytic cells.
Positive_regulation (induce) of Gene_expression (synthesis) of IL-12
3) Confidence 0.41 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.64 Pain Relevance 0.40
Effect of IL-12 and IL-18 on PHA/PMA-stimulated PBMCs
Positive_regulation (stimulated) of Gene_expression (Effect) of IL-12
4) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.45
IL-12 induced significant levels of IFN-?
Positive_regulation (induced) of Gene_expression (levels) of IL-12
5) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.34 Pain Relevance 0.17
While exogenous IL-18 showed a synergistic effect with IL-12 on IFN-?
Positive_regulation (synergistic) of Gene_expression (effect) of IL-12
6) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.67 Pain Relevance 0.33
In fact, LDR0723 favoured production of IL-12 rather than of IFN-?
Positive_regulation (fact) of Gene_expression (favoured) of IL-12
7) Confidence 0.28 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.54 Pain Relevance 0.18
Moreover, IL-12, IFN-?
Positive_regulation (Moreover) of Gene_expression (Moreover) of IL-12
8) Confidence 0.28 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.60 Pain Relevance 0.27
An increment in production of IL-12 levels was found also in cells stimulated with BNL1059 and RGS1746, even though they mainly oriented Th1/Th2 balance vs Th2.
Positive_regulation (increment) of Gene_expression (production) of IL-12
9) Confidence 0.28 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.45 Pain Relevance 0.17
Therefore, composition in LTA might influence release of inflammatory cytokines [16,17] as well as it has been shown that the strain-dependent ability to promote synthesis of IL-12 may arise, at least in part, from the amount of peptidoglycan present in gram-positive bacteria, and that integrity of bacterial cell wall is essential for the induction of IL-12 production [18,19].
Positive_regulation (induction) of Gene_expression (production) of IL-12 associated with inflammation, sprains and strains and cytokine
10) Confidence 0.28 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.55 Pain Relevance 0.22
Taken together, the findings presented in this study provide compelling ex vivo as well as in vivo evidence that heroin use or heroin use plus HCV infection, through the induction of two key suppressors (SOCS-3 and PIAS-3) in IL-12 pathway, suppressed IFN-?
Positive_regulation (induction) of Gene_expression (pathway) of IL-12 associated with hepatitis c virus infection, opiate addiction and infection
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.77 Pain Relevance 0
In particular, IL-12 and adjuvants that induce IL-12 production may be advantageous immune modulators by enhancing Th1 polarization.
Positive_regulation (induce) of Gene_expression (production) of IL-12
12) Confidence 0.26 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.30 Pain Relevance 0.13
NSAIDs up-regulated TNF, IFN-gamma and IL-2 production at both the mRNA and protein levels, and IL-12 expression at the mRNA level.
Positive_regulation (up-regulated) of Gene_expression (expression) of IL-12 associated with cinod
13) Confidence 0.25 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.30 Pain Relevance 0.64
Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin.
Positive_regulation (Augmentation) of Gene_expression (expression) of IL-12 in NK cell associated with enkephalin
14) Confidence 0.24 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 9772675 Disease Relevance 0 Pain Relevance 0.24
This increase was significant for IL-12/IL-4,
Positive_regulation (for) of Gene_expression (/) of IL-12
15) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.68 Pain Relevance 0.26
This increase was significant for IL-12/IL-4,
Positive_regulation (increase) of Gene_expression (significant) of IL-12
16) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.74 Pain Relevance 0.26
This increase was significant for IL-12/IL-4,
Positive_regulation (for) of Gene_expression (significant) of IL-12
17) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.73 Pain Relevance 0.26
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Spec (like) Positive_regulation (-stimulated) of Gene_expression (production) of IL-12 in THP-1
18) Confidence 0.16 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
TNF-alpha, TNF-beta, and IL-12 mRNA expression was maximally upmodulated on Day 14 p.i., i.e., at height of clinical EAN, favoring a role for these cytokines in disease development.
Positive_regulation (upmodulated) of Gene_expression (expression) of IL-12 mRNA associated with disease, neuritis and cytokine
19) Confidence 0.16 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.39 Pain Relevance 1.30
To study the potential role of cytokines in EAN, we used in situ hybridization to detect mRNA expression of interleukin 1 beta (IL-1 beta), IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-alpha), TNF-beta, and cytolysin in sciatic nerve sections over the course of EAN.
Positive_regulation (detect) of Gene_expression (expression) of IL-12 in sciatic nerve associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
20) Confidence 0.16 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.37 Pain Relevance 1.15

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