INT61627

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Context Info
Confidence 0.69
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.28
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
blood 1
monocyte 1
T cells 1
mononuclear cells 1
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 99.62 Very High Very High Very High
cytokine 60 99.32 Very High Very High Very High
Neuritis 10 92.20 High High
Inflammation 12 82.76 Quite High
corticosteroid 2 66.24 Quite High
dexamethasone 1 64.56 Quite High
methadone 4 51.44 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 99.76 Very High Very High Very High
Necrosis 4 99.52 Very High Very High Very High
Chlamydia Infection 140 98.04 Very High Very High Very High
Disease 9 97.76 Very High Very High Very High
Mycobacterial Infection 112 95.04 Very High Very High Very High
Optic Neuritis 10 92.20 High High
INFLAMMATION 13 89.00 High High
Congenital Anomalies 2 85.76 High High
Infection 62 84.40 Quite High
Cv General 3 Under Development 1 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study a possible relation between cytokine profiles and presence versus absence of MS-like brain MRI lesions and CSF OB, we used in situ hybridization to examine mRNA expression of the proinflammatory interleukin-12 (IL-12), interferon-gamma, and tumor necrosis factor-alpha and the immune response downregulating IL-10, transforming growth factor-beta, and IL-4 in blood and CSF mononuclear cells (MNC) from 59 patients with untreated ON.
Transcription (expression) of interferon-gamma in mononuclear cells associated with necrosis, cancer, neuritis and cytokine
1) Confidence 0.69 Published 1998 Journal Neurology Section Abstract Doc Link 9443483 Disease Relevance 0.90 Pain Relevance 0.71
NSAIDs up-regulated TNF, IFN-gamma and IL-2 production at both the mRNA and protein levels, and IL-12 expression at the mRNA level.
Transcription (mRNA) of IFN-gamma associated with cinod
2) Confidence 0.30 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.29 Pain Relevance 0.63
Cytokines produced by lymphocytes, such as interferon gamma, were not found, showing that the monocyte populations were reasonably pure.
Neg (not) Transcription (found) of interferon gamma in monocyte associated with cytokine
3) Confidence 0.11 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.25 Pain Relevance 0.37
Implementation of whole-blood interferon-gamma assay screening
Transcription (screening) of interferon-gamma in blood
4) Confidence 0.04 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434750 Disease Relevance 1.85 Pain Relevance 0.05
CD4+CD28null cells were separated by flow cytometry and assessed for antigen recognition using upregulation of interferon-gamma and perforin mRNA transcription as criteria for activation.
Transcription (transcription) of interferon-gamma
5) Confidence 0.03 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.08 Pain Relevance 0
Interferon-gamma secreting cells and mRNA expression in inc-stimulated cervical and peripheral CD4 positive T cells were significantly higher (P < 0.05) in CT positive fertile women compared to CT-positive women with fertility disorders.


Transcription (expression) of Interferon-gamma in T cells associated with chlamydia infection
6) Confidence 0.02 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2695819 Disease Relevance 0.91 Pain Relevance 0.06

General Comments

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