INT61628

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 20.96
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 10
lung 5
eosinophils 4
blood 4
thymocytes 4
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 860 100.00 Very High Very High Very High
aspirin 20 99.80 Very High Very High Very High
corticosteroid 34 99.64 Very High Very High Very High
cytokine 805 99.48 Very High Very High Very High
rheumatoid arthritis 139 99.38 Very High Very High Very High
agonist 178 99.22 Very High Very High Very High
cINOD 33 98.96 Very High Very High Very High
Inflammatory mediators 16 98.84 Very High Very High Very High
fortral 3 98.72 Very High Very High Very High
Inflammatory response 48 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 912 100.00 Very High Very High Very High
Rhinitis 110 100.00 Very High Very High Very High
Hyperplasia 67 100.00 Very High Very High Very High
Apoptosis 101 99.84 Very High Very High Very High
Rheumatoid Arthritis 139 99.38 Very High Very High Very High
Cancer 52 98.84 Very High Very High Very High
Asthma 2344 98.80 Very High Very High Very High
Syndrome 17 98.52 Very High Very High Very High
Inflammatory Bowel Disease 85 98.50 Very High Very High Very High
Eczema 39 98.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that beta-agonists, at low concentrations, predominantly inhibit IL-4 production and may therefore act as anti-inflammatory drugs in allergic asthma.
Negative_regulation (inhibit) of Gene_expression (production) of IL-4 associated with asthma, inflammation, cinod and agonist
1) Confidence 0.55 Published 1996 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8796447 Disease Relevance 0.20 Pain Relevance 0.27
Selective inhibition of interleukin-4 gene expression in human T cells by aspirin.
Negative_regulation (inhibition) of Gene_expression (expression) of interleukin-4 in T cells associated with aspirin
2) Confidence 0.52 Published 2001 Journal Blood Section Title Doc Link 11238116 Disease Relevance 0.07 Pain Relevance 0.35
It is concluded that anti-inflammatory salicylates, by means of a previously unrecognized mechanism of action, can influence the nature of adaptive immune responses by selectively inhibiting the expression of IL-4, a critical effector of these responses, in CD4+ T cells.
Negative_regulation (inhibiting) of Gene_expression (expression) of IL-4 in T cells associated with inflammation
3) Confidence 0.52 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.17 Pain Relevance 0.19
Dextrorphan significantly enhanced, pentazocine, haloperidol and phencyclidine had no effect, while SKF 10 047 suppressed production of IL-4.
Negative_regulation (suppressed) of Gene_expression (production) of IL-4 associated with fortral
4) Confidence 0.52 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.07 Pain Relevance 0.31
Salmeterol inhibits interferon-gamma and interleukin-4 production by human peripheral blood mononuclear cells.
Negative_regulation (inhibits) of Gene_expression (production) of interleukin-4 in mononuclear cells
5) Confidence 0.40 Published 1996 Journal Int. J. Immunopharmacol. Section Title Doc Link 8796447 Disease Relevance 0.10 Pain Relevance 0.12
Corticotropin releasing factor, adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone either inhibit or enhance in a dose-dependent fashion an interleukin-4 (IL-4) driven human IgE synthesis in vitro.
Negative_regulation (inhibit) of Gene_expression (synthesis) of IL-4 in melanocyte
6) Confidence 0.38 Published 1996 Journal Exp. Dermatol. Section Abstract Doc Link 8624610 Disease Relevance 0 Pain Relevance 0.07
The structurally unrelated nonsteroidal anti-inflammatory drugs indomethacin and flurbiprofen did not affect cytokine gene expression in T cells, whereas the weak cyclo-oxygenase inhibitor salicylic acid was at least as effective as ASA in inhibiting IL-4 expression and promoter activity.
Negative_regulation (inhibiting) of Gene_expression (expression) of IL-4 in T cells associated with inflammation, cinod and cytokine
7) Confidence 0.38 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.16 Pain Relevance 0.32
The present study suggests that the chronic immune response in RA is not caused by an intrinsic defect of naive CD4+ T cells of these patients to produce IL-4 in response to costimulation and differentiating factors such as IL-7 (and IL-4).
Negative_regulation (defect) of Gene_expression (produce) of IL-4 in T cells associated with rheumatoid arthritis
8) Confidence 0.35 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.23 Pain Relevance 0.39
However, heparan sulfate has been shown in vitro to promote a Th1 response, decreasing the production of IL-4 [184].
Negative_regulation (decreasing) of Gene_expression (production) of IL-4
9) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.59 Pain Relevance 0.31
By contrast, BNL1059 and RGS1746 favoured production of IL-4 which is known to promote production of IgE [10] and, at a lesser extent, of IL-5 which specifically controls production and activation and localization of eosinophils, the major cause of tissue damage in atopic disease [11].
Negative_regulation (favoured) of Gene_expression (production) of IL-4 in eosinophils associated with disease
10) Confidence 0.24 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.39 Pain Relevance 0.16
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decrease) of Gene_expression (levels) of IL-4 in blood
11) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.81 Pain Relevance 0.15
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decreased) of Gene_expression (levels) of IL-4 in blood
12) Confidence 0.22 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15
Suplatast tosilate is an oral agent that has been shown to inhibit the synthesis of both IL-4 and IL-5.11 Suplatast has been shown in early clinical trials to decrease serum IgE and peripheral blood eosinophil counts.12 Suplatast has also been shown to improve traditional asthma outcomes and decrease airway inflammation.13 However, this molecule has to be used in a three times per day regimen making its utility somewhat problematic since compliance would clearly be an issue.


Negative_regulation (inhibit) of Gene_expression (synthesis) of IL-4 in eosinophil associated with asthma and inflammation
13) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.58 Pain Relevance 0.05
These findings correlated with decreased levels of IL-4 and IL-5 in the airways in NES-treated animals [316].
Negative_regulation (decreased) of Gene_expression (levels) of IL-4
14) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.10 Pain Relevance 0
In an animal model of asthma intratracheally delivered AP-1 decoy oligodeoxynucleotides attenuate eosinophilic airway inflammation, airway hyperresponsiveness, mucous cell hyperplasia, production of allergen-specific immunoglobulins, and synthesis of IL-4, IL-5, and IL-13 in the lung [111].


Negative_regulation (attenuate) of in mucous cell Gene_expression (production) of IL-4 in lung associated with asthma, rhinitis, inflammation and hyperplasia
15) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.31 Pain Relevance 0.09
The pyrazole derivative, YM-58483 (BTP2; ), potently inhibits Ca2+ release-activated Ca2+ (CRAC) channels and IL-2 production in T cells and IL-4 and IL-5 production in stimulated murine Th2 cells, and IL-5 production in stimulated human whole blood cells.
Negative_regulation (inhibits) of Gene_expression (production) of IL-4 in T cells
16) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.28 Pain Relevance 0.22
In contrast, high-doses of montelukast reduce IL-4, IL-5 and IL-13 levels in the lung and IL-4 and IL-5 expression in BAL [39].
Negative_regulation (reduce) of Gene_expression (expression) of IL-4 in lung
17) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.81 Pain Relevance 0.42
In contrast, high-doses of montelukast reduce IL-4, IL-5 and IL-13 levels in the lung and IL-4 and IL-5 expression in BAL [39].
Negative_regulation (reduce) of Gene_expression (levels) of IL-4 in lung
18) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.42
In vitro cyclosporin A inhibit allergen-driven T-cell proliferation, production of IL-2, IL-4, and IL-5 by human CD4+ helper T cells, and IL-5 production in PBMCs from allergen-sensitized atopic asthmatic individuals at physiologic concentrations.
Negative_regulation (driven) of Gene_expression (production) of IL-4 in helper T cells associated with asthma
19) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.77 Pain Relevance 0.23
In contrast, NSAIDs down-regulated IL-6 production both at the mRNA and protein levels, and down-regulated IL-4 mRNA expression.
Negative_regulation (down-regulated) of Gene_expression (expression) of IL-4 associated with cinod
20) Confidence 0.16 Published 1995 Journal Cytokine Section Abstract Doc Link 8589268 Disease Relevance 0.31 Pain Relevance 0.60

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