INT6163

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 39
Total Number 39
Disease Relevance 2.90
Pain Relevance 14.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INA)
Anatomy Link Frequency
myocytes 1
chromaffin cells 1
external 1
dental pulp 1
ventricular myocardium 1
INA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 364 100.00 Very High Very High Very High
sodium channel 22 100.00 Very High Very High Very High
lidocaine 74 99.84 Very High Very High Very High
Action potential 127 99.58 Very High Very High Very High
depression 2 98.64 Very High Very High Very High
Pain 7 98.44 Very High Very High Very High
antiarrhythmic agent 3 97.16 Very High Very High Very High
action potential duration 41 96.76 Very High Very High Very High
addiction 42 95.44 Very High Very High Very High
local anesthetic 13 87.96 High High
Disease Link Frequency Relevance Heat
Syndrome 25 99.56 Very High Very High Very High
Depression 1 98.64 Very High Very High Very High
Pain 6 98.44 Very High Very High Very High
Small Cell Lung Cancer 8 97.08 Very High Very High Very High
Myocardial Infarction 46 95.40 Very High Very High Very High
Sprains And Strains 1 89.84 High High
Disease 8 87.00 High High
Dentin Sensitivity 1 82.52 Quite High
Congenital Anomalies 4 82.40 Quite High
Heart Rate Under Development 10 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recovery occurred after an initial delay at potentials positive to -140 mV, suggesting that inactivation of human atrial INa is a multistate process.
Negative_regulation (inactivation) of INa
1) Confidence 0.43 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1323431 Disease Relevance 0.09 Pain Relevance 0.21
Both INa and Io1 were inactivated when segments were clamped at voltages more positive than -50 mV, whereas Io2 could be activated at voltages more positive than -50 mV.
Negative_regulation (inactivated) of INa
2) Confidence 0.42 Published 1983 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 6325012 Disease Relevance 0 Pain Relevance 0.09
These characteristics of lidocaine block suggest that lidocaine binds to both inactivated and activated Na+ channels in human atrial cells and that use-dependent block of INa by lidocaine is dependent on drug concentration, interpulse interval and pulse duration, findings similar to those reported for other mammalian species.
Negative_regulation (block) of INa associated with lidocaine
3) Confidence 0.38 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8383745 Disease Relevance 0 Pain Relevance 0.87
However, when trains of pulses to -10 mV from a holding potential of -110 mV were applied at 1 to 5 Hz, use-dependent inhibition of INa occurred, suggesting that 100 microM metoprolol may interact with inactivated Na channels to inhibit INa.
Negative_regulation (inhibition) of INa
4) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1690800 Disease Relevance 0 Pain Relevance 0.18
However, when trains of pulses to -10 mV from a holding potential of -110 mV were applied at 1 to 5 Hz, use-dependent inhibition of INa occurred, suggesting that 100 microM metoprolol may interact with inactivated Na channels to inhibit INa.
Negative_regulation (inhibit) of INa
5) Confidence 0.37 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1690800 Disease Relevance 0 Pain Relevance 0.15
The data obtained provide evidence in favour of the hypothesis about the existence of the different binding sites responsible for cumulative blockade of the INa induced by tertiary and quaternary amines.
Negative_regulation (blockade) of INa associated with sodium channel
6) Confidence 0.37 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2410054 Disease Relevance 0 Pain Relevance 0.55
Modifications of drug-induced Vmax inhibition by the combined treatment of the cardiac membrane with several class 1 antiarrhythmic agents were studied in guinea pig's ventricular myocardium taking the depression of upstroke velocity in fast action potentials as an indicator for INa blockade.
Negative_regulation (blockade) of INa in ventricular myocardium associated with action potential, depression and antiarrhythmic agent
7) Confidence 0.37 Published 1985 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2414674 Disease Relevance 0.10 Pain Relevance 0.31
Increasing external [Ca2+] or [Mg2+]decreased INa and slowed its rate of inactivation.
Negative_regulation (decreased) of INa in external
8) Confidence 0.37 Published 1998 Journal J. Vasc. Res. Section Abstract Doc Link 9789111 Disease Relevance 0 Pain Relevance 0.34
At pH 6.5, INa block developed with a single exponential function revealing only the slow component.
Negative_regulation (block) of INa
9) Confidence 0.35 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1660356 Disease Relevance 0 Pain Relevance 0.23
Development of INa block by lidocaine also was expressed by two exponentials at all pulse durations (5-200 msec).
Negative_regulation (block) of INa associated with lidocaine
10) Confidence 0.35 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1660356 Disease Relevance 0 Pain Relevance 0.31
We studied the kinetics of the use-dependent block of the Na+ current (INa) by disopyramide and lidocaine.
Negative_regulation (block) of INa associated with lidocaine
11) Confidence 0.35 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1660356 Disease Relevance 0 Pain Relevance 0.17
The use-dependent block of INa by disopyramide with 20- and 200-msec depolarizing pulses developed in two exponential functions.
Negative_regulation (block) of INa
12) Confidence 0.35 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1660356 Disease Relevance 0 Pain Relevance 0.17
In contrast to the significant reduction of INA and its perceptual correlate of sharp pain after adrenaline administration, the electrical detection threshold remained constant during the full test period, suggesting that electrical threshold measurements have their limitations as a diagnostic tool or criterion for assessing the sensitivity of the dental pulp.
Negative_regulation (reduction) of INA in dental pulp associated with pain
13) Confidence 0.34 Published 1999 Journal Endod Dent Traumatol Section Abstract Doc Link 10219148 Disease Relevance 0.74 Pain Relevance 0.64
We found that tonic block of peak INa by lidocaine (200 microM, holding potential = -140 mV, 0.1 Hz, at 17 degrees C) was not voltage dependent in either cell type.
Negative_regulation (block) of INa associated with lidocaine
14) Confidence 0.34 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776390 Disease Relevance 0.08 Pain Relevance 0.42
IKir was blocked by Ba2+ and ICl.vol was inhibited by DIDS or NPPB, while INa.TTX and INa.TTXR were suppressed by different concentrations of TTX.
Negative_regulation (suppressed) of INa associated with tetrodotoxin
15) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.44
IKir was blocked by Ba2+ and ICl.vol was inhibited by DIDS or NPPB, while INa.TTX and INa.TTXR were suppressed by different concentrations of TTX.
Negative_regulation (suppressed) of INa associated with tetrodotoxin
16) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.44
The IC50 (50% inhibitory concentration) of TTX for inhibiting INa.TTX was 7.8 nM with a coefficient of 0.94, while the IC50 of TTX for inhibiting INa.TTXR was 1.8 µM with a Hill coefficient of 0.58.
Negative_regulation (inhibiting) of INa associated with tetrodotoxin
17) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.30
The concentration-dependent inhibitory effects of TTX on INa.TTX and INa.TTXR at 0 mV are illustrated in Fig. 6E.
Negative_regulation (effects) of INa associated with tetrodotoxin
18) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.24
The IC50 (50% inhibitory concentration) of TTX for inhibiting INa.TTX was 7.8 nM with a coefficient of 0.94, while the IC50 of TTX for inhibiting INa.TTXR was 1.8 µM with a Hill coefficient of 0.58.
Negative_regulation (inhibiting) of INa associated with tetrodotoxin
19) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.30
The concentration-dependent inhibitory effects of TTX on INa.TTX and INa.TTXR at 0 mV are illustrated in Fig. 6E.
Negative_regulation (effects) of INa associated with tetrodotoxin
20) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.23

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