INT61635

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Context Info
Confidence 0.56
First Reported 1995
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 35
Total Number 43
Disease Relevance 12.08
Pain Relevance 14.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
striatum 2
central nervous system 2
spinal cord 2
microglia 2
nerve 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 264 99.98 Very High Very High Very High
Dopamine 75 99.82 Very High Very High Very High
Neuropathic pain 48 99.70 Very High Very High Very High
Central nervous system 164 99.68 Very High Very High Very High
spinal dorsal horn 15 99.58 Very High Very High Very High
nMDA receptor 60 98.96 Very High Very High Very High
Spinal cord 117 98.68 Very High Very High Very High
adenocard 219 98.48 Very High Very High Very High
Brush evoked pain 32 98.44 Very High Very High Very High
Hippocampus 141 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 116 99.70 Very High Very High Very High
Neuroblastoma 38 99.48 Very High Very High Very High
Hypoxia 118 99.00 Very High Very High Very High
Ganglion Cysts 384 98.96 Very High Very High Very High
Nervous System Injury 43 98.88 Very High Very High Very High
Nociception 67 98.84 Very High Very High Very High
Glioma 12 98.84 Very High Very High Very High
Hyperalgesia 17 97.80 Very High Very High Very High
Pain 280 97.44 Very High Very High Very High
Encephalitis 2 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double labeling studies revealed that cells expressing increased P2Y(12) mRNA and protein after nerve injury were exclusively microglia.
Positive_regulation (increased) of P2Y in microglia associated with nervous system injury
1) Confidence 0.56 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.85 Pain Relevance 0.89
The presumed P2Y15 receptor is also activated by ?
Positive_regulation (activated) of P2Y15 receptor
2) Confidence 0.47 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.09
Time averaged normalized sensitivities for three model outputs (cytosolic calcium, concentration of gated IP3R channels, Gq-protein activation) were computed over the parameter family as a function of P2Y and P2X activation (Fig. 6A–C).
Positive_regulation (activation) of P2Y
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0.03
G protein cascade components were also only sensitive following P2Y activation.
Positive_regulation (activation) of P2Y
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.58 Pain Relevance 0.71
We assumed that the G protein-coupled IPx dynamics from these receptors was similar to ATP stimulation of P2Y receptors.
Positive_regulation (stimulation) of P2Y
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.07 Pain Relevance 0.04
During mucosal mechanical reflexes, it is postulated that P2Y1 R, P2Y2 R, and P2Y4 R are activated by endogenous ATP, UTP, and 5'uridine-diphosphate.
Positive_regulation (activated) of P2Y2
6) Confidence 0.42 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0 Pain Relevance 0.18
Extracellular nucleotides activate P2Y and P2X receptors either paracrinally (1) or autocrinally (2), leading to modulation of gene expression.
Positive_regulation (activate) of P2Y
7) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.34 Pain Relevance 0.31
As mentioned above, the highly specific functions of nucleotides are mediated by the activation of P2X and P2Y receptors on target cells.
Positive_regulation (activation) of P2Y
8) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.52 Pain Relevance 0.07
However, it remains unknown whether any type of P2Y receptor in microglia is involved in the activation of p38 MAPK and the pain behaviors after nerve injury.
Spec (whether) Positive_regulation (type) of P2Y receptor in nerve associated with pain and nervous system injury
9) Confidence 0.41 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.67 Pain Relevance 0.65
It was suggested that mediation of Ca2+ waves by ATP leading to activation of two subtypes of receptor, P2Y1 and P2Y2, may be a general principle for gliotransmission in the central nervous system [73].


Positive_regulation (activation) of P2Y2 in central nervous system associated with central nervous system
10) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.06 Pain Relevance 0.50
These data suggest that P2Y2 receptor activation and the subsequent increase of [Ca2+]i may be accompanied by the release of the neuropeptide CGRP from the first order sensory neurons stimulating pain transmission.
Positive_regulation (activation) of P2Y2 receptor in sensory neurons associated with pain, neuropeptide and calcitonin gene-related peptide
11) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.75 Pain Relevance 0.76
In addition, ATP was found to directly inhibit NMDA receptors independently of G proteins and, therefore, not by activation of P2Y receptors.
Neg (not) Positive_regulation (activation) of P2Y associated with nmda receptor
12) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.08 Pain Relevance 0.46
The presumed P2Y15 receptor is also activated by ?
Positive_regulation (activated) of P2Y15 receptor
13) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.09
Thus, P2Y receptor activation may also interfere with synaptic transmission via a modulation of postsynaptic ionotropic receptors.
Positive_regulation (activation) of P2Y receptor
14) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.19
These data suggest a new mechanism of neuropathic pain, in which the increased P2Y(12) works as a gateway of the following events in microglia after nerve injury.
Positive_regulation (increased) of P2Y in nerve associated with nervous system injury and neuropathic pain
15) Confidence 0.33 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.88 Pain Relevance 0.88
ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum.
Positive_regulation (stimulation) of P2Y in striatum associated with dopamine
16) Confidence 0.32 Published 1995 Journal Brain Res. Section Title Doc Link 8590054 Disease Relevance 0.07 Pain Relevance 0.81
The ATP-induced increase in DA is presumably due to the release of DA via the stimulation of P2Y purinoceptors in the rat striatum.
Positive_regulation (stimulation) of P2Y in striatum associated with dopamine
17) Confidence 0.32 Published 1995 Journal Brain Res. Section Abstract Doc Link 8590054 Disease Relevance 0.08 Pain Relevance 0.84
An increase in the immunofluorescence of P2Y(12)R protein in the ipsilateral spinal cord was also observed after nerve injury, and P2Y(12)R-positive cells were double labeled with the microglial marker OX-42.
Positive_regulation (increase) of P2Y in spinal cord associated with nervous system injury and spinal cord
18) Confidence 0.32 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463248 Disease Relevance 1.18 Pain Relevance 0.87
Only a few years later, after the cloning of the first G protein-coupled nucleotide receptors, Filippov et al. [99] could demonstrate that activation of the PLC-linked P2Y2 receptor in NG108-15 neuroblastoma × glioma hybrid cells led to an inhibition of native IM.
Positive_regulation (activation) of P2Y2 receptor in NG108-15 associated with neuroblastoma and glioma
19) Confidence 0.31 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.28 Pain Relevance 0
When co-expressed together with the P2X1 receptor, activation of both, P2Y1 and P2Y2, caused a significant potentiation of the ?
Positive_regulation (activation) of P2Y2
20) Confidence 0.31 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.14 Pain Relevance 0.23

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