INT61636

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Context Info
Confidence 0.34
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.13
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
striatum 2
central nervous system 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
Central nervous system 2 97.72 Very High Very High Very High
Antinociceptive 4 93.04 High High
agonist 38 90.08 High High
Potency 5 88.76 High High
cytokine 3 87.60 High High
adenocard 11 85.64 High High
Spinal cord 18 85.04 High High
antagonist 23 76.92 Quite High
tetrodotoxin 3 60.40 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 13 71.16 Quite High
Pain 44 58.88 Quite High
Ganglion Cysts 96 44.52 Quite Low
Injury 2 7.64 Low Low
Neuropathic Pain 6 5.76 Low Low
Nociception 20 5.00 Very Low Very Low Very Low
Neuroblastoma 5 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that mediation of Ca2+ waves by ATP leading to activation of two subtypes of receptor, P2Y1 and P2Y2, may be a general principle for gliotransmission in the central nervous system [73].


Positive_regulation (leading) of Positive_regulation (activation) of P2Y2 in central nervous system associated with central nervous system
1) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.06 Pain Relevance 0.50
The presumed P2Y15 receptor is also activated by ?
Positive_regulation (activated) of Positive_regulation (activated) of P2Y15 receptor
2) Confidence 0.34 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.09
ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum.
Positive_regulation (increases) of Positive_regulation (stimulation) of P2Y in striatum associated with dopamine
3) Confidence 0.32 Published 1995 Journal Brain Res. Section Title Doc Link 8590054 Disease Relevance 0.07 Pain Relevance 0.81
Components involved in calcium homeostasis for example, SERCA and PMCA pumps were globally important for both P2X and P2Y activation.
Positive_regulation (important) of Positive_regulation (activation) of P2Y
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0 Pain Relevance 0

General Comments

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