INT6164

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 2.19
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INA)
Anatomy Link Frequency
cardiac myocytes 2
uterine smooth muscle 1
external 1
teeth 1
INA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 109 100.00 Very High Very High Very High
sodium channel 23 100.00 Very High Very High Very High
addiction 53 99.92 Very High Very High Very High
Pain 9 97.44 Very High Very High Very High
Action potential 256 97.36 Very High Very High Very High
local anesthetic 8 86.68 High High
Calcium channel 8 79.48 Quite High
lidocaine 38 69.76 Quite High
agonist 13 59.92 Quite High
potassium channel 4 53.92 Quite High
Disease Link Frequency Relevance Heat
Syndrome 44 99.78 Very High Very High Very High
Uterine Cancer 1 99.56 Very High Very High Very High
Pain 8 97.44 Very High Very High Very High
Sarcoma 1 96.80 Very High Very High Very High
Disease 15 87.00 High High
Myocardial Infarction 113 84.40 Quite High
Heart Disease 3 83.32 Quite High
Heart Arrhythmia 8 81.72 Quite High
Arrhythmia Under Development 45 78.88 Quite High
Leiomyosarcoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that one or more factors in serum induce INa(f) in the uterine sarcoma cells, and this cell line could be a good model for the study of the fast Na+ channels in uterine smooth muscle.
Positive_regulation (induce) of INa in uterine smooth muscle associated with uterine cancer
1) Confidence 0.67 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977692 Disease Relevance 0.34 Pain Relevance 0.09
Recovery occurred after an initial delay at potentials positive to -140 mV, suggesting that inactivation of human atrial INa is a multistate process.
Positive_regulation (inactivation) of INa
2) Confidence 0.50 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1323431 Disease Relevance 0.09 Pain Relevance 0.21
INa was activated at a voltage threshold of -70 to -60 mV, and peak inward current was obtained at approximately -30 mV (holding potential, -140 mV).
Positive_regulation (activated) of INa
3) Confidence 0.47 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1323431 Disease Relevance 0.06 Pain Relevance 0.19
Inactivation of INa.TTX and INa.TTXR was fitted to a monoexponential function with time constant (?)
Positive_regulation (Inactivation) of INa associated with tetrodotoxin
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.16
Inactivation of INa.TTX and INa.TTXR was fitted to a monoexponential function with time constant (?)
Positive_regulation (Inactivation) of INa associated with tetrodotoxin
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.16
Intradental nerve activity (INA) induced by cold stimulation of human teeth is regularly accompanied by pain perception.
Positive_regulation (induced) of INA in teeth associated with pain
6) Confidence 0.41 Published 1984 Journal Pain Section Abstract Doc Link 6328400 Disease Relevance 0.39 Pain Relevance 0.39
These different INa were activated at similar range of potentials (approximately -45 mV), had similar sensitivity to tetrodotoxin (IC50 around 5 nM) and similar density (2 to 4 pA/pF).
Positive_regulation (activated) of INa associated with tetrodotoxin
7) Confidence 0.41 Published 2000 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 10989746 Disease Relevance 0.26 Pain Relevance 0.16
The data obtained provide evidence in favour of the hypothesis about the existence of the different binding sites responsible for cumulative blockade of the INa induced by tertiary and quaternary amines.
Positive_regulation (induced) of INa associated with sodium channel
8) Confidence 0.40 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2410054 Disease Relevance 0 Pain Relevance 0.55
Lowering external [Ca2+] to zero increased the maximum INa, shifted its voltage dependence in the hyperpolarizing direction and increased the rate of INa inactivation.
Positive_regulation (increased) of INa in external associated with addiction
9) Confidence 0.40 Published 1998 Journal J. Vasc. Res. Section Abstract Doc Link 9789111 Disease Relevance 0 Pain Relevance 0.34
INa activated at depolarizations positive to -50 mV, was maximal at 0 mV, and was available from relatively low resting membrane potentials (half-inactivation at -46 mV).
Positive_regulation (activated) of INa
10) Confidence 0.40 Published 1997 Journal Circ. Res. Section Abstract Doc Link 9048658 Disease Relevance 0.08 Pain Relevance 0.32
They found that temperature clearly affected the voltage dependence of INa (in)activation, resulting in a more positive membrane potential for the half maximal (in)activation) at higher temperatures [28].
Positive_regulation (activation) of INa associated with addiction
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0.08 Pain Relevance 0.05
To determine the activation characteristics of INa, current-voltage curves were corrected for differences in driving force and normalized to maximum peak current.
Spec (determine) Positive_regulation (activation) of INa
12) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0.11
However, investigation of Na+ channel kinetics with near-physiological ion concentrations and temperature is technically challenging due to the large amplitude and rapidly activating nature of INa, which may seriously hamper the quality of voltage control over the membrane [10].
Positive_regulation (activating) of INa
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013114 Disease Relevance 0.19 Pain Relevance 0.03
Unfortunately, in cardiac myocytes, investigation of kinetic properties of INa with near-physiological ion concentrations and temperature is technically challenging due to the large amplitude and rapidly activating nature of INa, which may seriously hamper the quality of voltage control over the membrane.
Positive_regulation (activating) of INa in cardiac myocytes
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013114 Disease Relevance 0 Pain Relevance 0.18
Transmural dispersion of repolarization has been found to increase significantly after administration of veratridine, which leads to type 3 of long QT (LQT) syndrome (LQTS) owing to augmented INa(late) (Milberg et al. 2005).
Positive_regulation (augmented) of INa associated with syndrome
15) Confidence 0.19 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.49 Pain Relevance 0.03
From a biophysical point of view, INa(T) is activated following membrane depolarization, inactivates quickly and is responsible for the upstroke phase of the cardiac AP as well as for the entrainment system between neighbouring cells that guarantees a proper conduction of the electrical stimulus.
Positive_regulation (activated) of INa associated with action potential
16) Confidence 0.19 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.07 Pain Relevance 0.18
Two distinct components of the Na+ current have been identified in cardiac myocytes: a transient component (INa(T)) and a persistent component (INa(P), also termed INa(late)).
Positive_regulation (termed) of INa in cardiac myocytes
17) Confidence 0.15 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.08 Pain Relevance 0.12
From a biophysical point of view, INa(T) is activated following membrane depolarization, inactivates quickly and is responsible for the upstroke phase of the cardiac AP as well as for the entrainment system between neighbouring cells that guarantees a proper conduction of the electrical stimulus.
Positive_regulation (inactivates) of INa associated with action potential
18) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.07 Pain Relevance 0.19
The INa was elicited by depolarizing test pulses from a holding potential of -80 mV in reduced Na+ solution (10 mM).
Positive_regulation (elicited) of INa
19) Confidence 0.05 Published 1998 Journal Anesthesiology Section Body Doc Link 9447864 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox