INT61643

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.04
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ACVRL1)
Anatomy Link Frequency
tubes 1
smooth muscle 1
anatomy 1
astrocyte 1
ACVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 96.04 Very High Very High Very High
headache 2 91.44 High High
Angina 2 88.16 High High
imagery 15 81.16 Quite High
cva 3 76.48 Quite High
fibrosis 7 73.32 Quite High
Pain 3 71.92 Quite High
positron emission tomography 4 66.88 Quite High
abdominal pain 5 57.36 Quite High
antagonist 5 53.20 Quite High
Disease Link Frequency Relevance Heat
Telangiectasia 59 100.00 Very High Very High Very High
Malignant Neoplastic Disease 3 99.76 Very High Very High Very High
Nose Bleeds 10 98.38 Very High Very High Very High
Vascular Malformations 6 98.32 Very High Very High Very High
Pulmonary Hypertension 255 97.28 Very High Very High Very High
Epstein-barr Virus 13 96.84 Very High Very High Very High
Brain Abscess 3 96.64 Very High Very High Very High
INFLAMMATION 10 96.04 Very High Very High Very High
Aneurism 8 95.32 Very High Very High Very High
Pressure And Volume Under Development 6 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that HHT can produce abnormal abdominal vascular anatomy, which affects haemodynamic performance and makes it difficult to manage a patient with portal hypertension caused by secondary biliary cirrhosis.
Gene_expression (produce) of HHT in anatomy associated with biliary liver cirrhosis, pressure and volume under development and telangiectasia
1) Confidence 0.51 Published 1995 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 8590149 Disease Relevance 1.86 Pain Relevance 0.08
The spindle cells were strongly reactive for smooth muscle actin but negative for ALK-1.
Neg (negative) Gene_expression (negative) of ALK-1 in smooth muscle
2) Confidence 0.51 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17090200 Disease Relevance 1.01 Pain Relevance 0.28
Further postoperative evaluation revealed a history of epistaxis, perioral telangiectasias, hepatic hypervascularity, and a mutation in the gene expressing activin receptor-like kinase 1 (ALK1), leading to a diagnosis of hereditary hemorrhagic telangiectasia.
Gene_expression (expressing) of ALK1 associated with nose bleeds and telangiectasia
3) Confidence 0.51 Published 2010 Journal J. Vasc. Surg. Section Abstract Doc Link 20141966 Disease Relevance 1.07 Pain Relevance 0.09
The etiological research revealed multiple PAVMs and mucocutaneous telangiectasis consistent with HHT
Gene_expression (consistent) of HHT associated with telangiectasia
4) Confidence 0.49 Published 2008 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2705726 Disease Relevance 1.05 Pain Relevance 0.27
Additionally, mutations in activin-like kinase type-1 (ALK-1), another transforming growth factor-beta (TGF-?)
Gene_expression (mutations) of ALK-1
5) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 1.38 Pain Relevance 0.04
Intriguingly, ROBO4 is upregulated in mice lacking the ALK-1 gene, which is mutated in some cases of FPAH, and these mice characteristically have aberrant fusion of endothelial tubes [33].
Gene_expression (mutated) of ALK-1 gene in tubes
6) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.29 Pain Relevance 0
Additionally, mutations in activin-like kinase type-1 (ALK-1), another transforming growth factor-beta (TGF-?)
Gene_expression (mutations) of activin-like kinase type-1
7) Confidence 0.10 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 1.33 Pain Relevance 0.04
This result was not necessarily predictable since ALK1 is activated by BMPs, and has been previously implicated in astrocyte development.
Gene_expression (activated) of ALK1 in astrocyte
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.07 Pain Relevance 0.03
The malignant cells were negative for CD20, CD30, CD45, CD5, Alk-1 and TCK.
Neg (negative) Gene_expression (negative) of Alk-1 associated with malignant neoplastic disease
9) Confidence 0.01 Published 2011 Journal J Med Case Reports Section Body Doc Link PMC3024289 Disease Relevance 0.98 Pain Relevance 0.22

General Comments

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