INT61644

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Context Info
Confidence 0.70
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 11.35
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) extracellular space (Gc) extracellular region (Gc)
Anatomy Link Frequency
liver 4
plasma 1
tubes 1
blood 1
thyroid 1
Gc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 2 95.60 Very High Very High Very High
Multiple sclerosis 2 95.56 Very High Very High Very High
Paracetamol 41 94.80 High High
Angina 2 85.40 High High
ischemia 47 75.56 Quite High
cytokine 4 73.64 Quite High
rheumatoid arthritis 1 46.56 Quite Low
Tendonitis 1 45.12 Quite Low
Inflammation 16 43.96 Quite Low
cva 7 34.76 Quite Low
Disease Link Frequency Relevance Heat
Liver Disease 30 99.92 Very High Very High Very High
Hepatic Encephalopathy 20 99.64 Very High Very High Very High
Toxicity 4 99.40 Very High Very High Very High
Hepatotoxicity 7 99.28 Very High Very High Very High
Coma 5 99.16 Very High Very High Very High
Acute Liver Failure 62 99.14 Very High Very High Very High
Pulmonary Disease 4 98.52 Very High Very High Very High
Sepsis 2 98.16 Very High Very High Very High
Multiple Organ Failure 19 97.68 Very High Very High Very High
Thyroid Disease 2 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gc-globulin levels in the two patients who died did not differ from those in patients who survived hepatic encephalopathy.
Gene_expression (levels) of Gc-globulin
1) Confidence 0.70 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0.08 Pain Relevance 0
Many studies suggest an association between Gc-globulin phenotypes and resistance or susceptibility to chronic obstructive pulmonary disease (COPD), thyroid diseases, diabetes, multiple sclerosis, and sarcoidosis.
Gene_expression (phenotypes) of Gc-globulin in thyroid associated with multiple sclerosis, pulmonary disease, sarcoidosis, diabetes mellitus and thyroid disease
2) Confidence 0.64 Published 2008 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 19002085 Disease Relevance 1.16 Pain Relevance 0.24
It is also called vitamin D-binding protein (DBP).
Gene_expression (called) of vitamin D-binding protein
3) Confidence 0.64 Published 2008 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 19002085 Disease Relevance 0.51 Pain Relevance 0.14
Gc-globulin is synthesized in the liver and is a multifunctional protein; however, its main physiologic function is presumably actin binding and actin scavenging.
Gene_expression (synthesized) of Gc-globulin in liver
4) Confidence 0.60 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 0.56 Pain Relevance 0.12
Surprisingly, kinetic studies in patients with ALF and acute on chronic liver disease showed Gc-globulin production to be 7-fold increased in these conditions.
Gene_expression (production) of Gc-globulin in liver associated with liver disease and acute liver failure
5) Confidence 0.60 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 1.50 Pain Relevance 0.14
Admission serum levels of Gc-globulin (normal range: 350-500 mg/L) were studied by an immunonephelometric method.
Gene_expression (levels) of Gc-globulin
6) Confidence 0.53 Published 2005 Journal Liver Transpl. Section Abstract Doc Link 16184570 Disease Relevance 0.62 Pain Relevance 0.19
Patients with chronic liver disease had reduced Gc-globulin levels, but the reduction was less pronounced than in ALF.
Gene_expression (levels) of Gc-globulin in liver associated with liver disease and acute liver failure
7) Confidence 0.52 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 1.30 Pain Relevance 0.07
In my studies, I found serum Gc-globulin levels to be reduced in liver disease, most so in patients with acute liver failure (ALF).
Gene_expression (levels) of Gc-globulin in liver associated with liver disease and acute liver failure
8) Confidence 0.52 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 0.85 Pain Relevance 0.26
In ALF patients with deep coma (hepatic encephalopathy grade III or IV) Gc-globulin levels correlated inversely with the number of failing organs.
Gene_expression (levels) of Gc-globulin associated with hepatic encephalopathy, acute liver failure and coma
9) Confidence 0.52 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 1.60 Pain Relevance 0.28
Extreme values occurred at 60 to 72 hours postoverdose, a period in which Gc-globulin protection against actin toxicity may be inadequate.
Gene_expression (protection) of Gc-globulin associated with toxicity
10) Confidence 0.50 Published 2001 Journal Liver Transpl. Section Abstract Doc Link 11510020 Disease Relevance 0.81 Pain Relevance 0.07
In conclusion, Gc-globulin is severely stressed in patients with hepatotoxicity.
Gene_expression (stressed) of Gc-globulin associated with hepatotoxicity
11) Confidence 0.50 Published 2001 Journal Liver Transpl. Section Abstract Doc Link 11510020 Disease Relevance 0.87 Pain Relevance 0.13
BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels.
Gene_expression (levels) of globulin in blood
12) Confidence 0.24 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18543385 Disease Relevance 0.07 Pain Relevance 0.09
Moreover, fresh thrombotic plaques, obtained during primary angioplasty, showed high expression of VDB protein.
Gene_expression (expression) of VDB protein in plaques
13) Confidence 0.16 Published 2010 Journal Front Biosci (Elite Ed) Section Abstract Doc Link 20515752 Disease Relevance 0.34 Pain Relevance 0.07
Our proteomic approach identified increased levels of vitamin D-binding protein precursor (VDB) in the serum of STEMI patients when compared to control donors.
Gene_expression (levels) of vitamin D-binding protein precursor
14) Confidence 0.16 Published 2010 Journal Front Biosci (Elite Ed) Section Abstract Doc Link 20515752 Disease Relevance 0.38 Pain Relevance 0.09
Supernatants were transferred into fresh tubes for evaluation of concentration of glutamic-oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), the ratio of AST compare ALT (S/L), total protein (TP), albumin (ALB), globulin (GLB), the ratio of ALB compare GLB (A/G), phosphocreatine kinase (CK), lactate dehydrogenase (LDH), urea nitrogen (BUN) and creatinine (CRE) through automatic biochemistry analyzer(abbott, USA).


Gene_expression (compare) of globulin in tubes
15) Confidence 0.07 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.22 Pain Relevance 0.04
Göker at al. demonstrated that coagulation factors II, V, VII, VIII, IX, X, XI, and XIII were not affected, and that plasma fibrinogen activity as well as total protein, albumin, and globulin levels were decreased by the addition of ABS to plasma [6,7].
Gene_expression (levels) of globulin in plasma
16) Confidence 0.02 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2993704 Disease Relevance 0.48 Pain Relevance 0.04

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