INT61645

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Context Info
Confidence 0.51
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 10.44
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gc) extracellular space (Gc) extracellular region (Gc)
Anatomy Link Frequency
liver 6
plasma 1
blood 1
hepatocyte 1
Gc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 52 99.28 Very High Very High Very High
Inflammation 20 95.60 Very High Very High Very High
depression 2 95.04 Very High Very High Very High
bradykinin 1 91.96 High High
Arthritis 17 82.12 Quite High
cytokine 1 73.64 Quite High
diclofenac 6 54.64 Quite High
rheumatoid arthritis 8 48.48 Quite Low
Tendonitis 1 47.04 Quite Low
cva 2 34.76 Quite Low
Disease Link Frequency Relevance Heat
Liver Disease 18 99.90 Very High Very High Very High
Acute Liver Failure 60 99.84 Very High Very High Very High
Arthritis 51 99.60 Very High Very High Very High
Hepatic Encephalopathy 31 99.32 Very High Very High Very High
Poisoning 14 98.80 Very High Very High Very High
Hepatotoxicity 10 96.08 Very High Very High Very High
INFLAMMATION 20 95.60 Very High Very High Very High
Necrosis 16 95.08 Very High Very High Very High
Coagulation Disorder 1 92.32 High High
Multiple Organ Failure 9 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we found that Gc-globulin levels were markedly decreased in patients with ALF; the lowest levels were observed in patients who died or were transplanted.
Negative_regulation (decreased) of Gc-globulin associated with acute liver failure
1) Confidence 0.51 Published 2005 Journal Liver Transpl. Section Abstract Doc Link 16184570 Disease Relevance 0.72 Pain Relevance 0.42
Gc-globulin levels were significantly reduced in 47 nonsurvivors, compared with 30 survivors (96 +/- 71 mg/L vs. 169 +/- 101 mg/L, P < .001), whereas the complex ratio in nonsurvivors did not differ significantly from that of survivors.
Negative_regulation (reduced) of Gc-globulin
2) Confidence 0.51 Published 1996 Journal Hepatology Section Abstract Doc Link 8666322 Disease Relevance 0.51 Pain Relevance 0.27
In conclusion, Gc-globulin levels were found to be decreased in patients with paracetamol intoxication; this decrease correlated with the most severe sign of liver dysfunction, HE.
Negative_regulation (decreased) of Gc-globulin in liver associated with paracetamol, hepatic encephalopathy, hepatotoxicity and poisoning
3) Confidence 0.51 Published 1996 Journal Ugeskr. Laeg. Section Abstract Doc Link 8966827 Disease Relevance 1.36 Pain Relevance 0.37
Serum concentrations of the actin scavenger Gc-globulin are reduced in acute liver failure (ALF).
Negative_regulation (reduced) of Gc-globulin in liver associated with acute liver failure
4) Confidence 0.51 Published 2005 Journal Liver Transpl. Section Abstract Doc Link 16184570 Disease Relevance 0.59 Pain Relevance 0.11
RESULTS: On admission, all patients had significantly reduced serum Gc-globulin levels compared with normal individuals (P < 0.0001); patients with HE had significantly lower values than patients without HE (P < 0.001).
Negative_regulation (reduced) of Gc-globulin
5) Confidence 0.46 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0.08 Pain Relevance 0
Despite this increase Gc-globulin levels were severely reduced and the reduction must therefore be due to a highly increased consumption of Gc-globulin - probably because of hepatocyte necrosis and removal from the circulation of Gc-globulin:actin complexes or because of its role in immune-related functions.
Negative_regulation (reduced) of Gc-globulin in hepatocyte associated with necrosis
6) Confidence 0.46 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 1.38 Pain Relevance 0.13
On admission all patients had significantly reduced serum Gc-globulin levels compared to normal individuals, and patients with HE had significantly lower values than patients without HE.
Negative_regulation (reduced) of Gc-globulin associated with hepatic encephalopathy
7) Confidence 0.45 Published 1996 Journal Ugeskr. Laeg. Section Abstract Doc Link 8966827 Disease Relevance 1.14 Pain Relevance 0.39
In these 2 groups, total and free Gc-globulin levels decreased to 97 and 50 mg/L and 148 and 86 mg/L, respectively (normal mean, 340 and 299 mg/L), the nadir occurring at 72 hours postoverdose.
Negative_regulation (decreased) of Gc-globulin
8) Confidence 0.43 Published 2001 Journal Liver Transpl. Section Abstract Doc Link 11510020 Disease Relevance 0.78 Pain Relevance 0.29
CONCLUSION: Gc-globulin levels were decreased in individuals suffering from acetaminophen intoxication; this decrease correlated with the most severe sign of liver dysfunction, HE.
Negative_regulation (decreased) of Gc-globulin in liver
9) Confidence 0.39 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Gc-globulin levels were decreased in individuals suffering from acetaminophen intoxication; this decrease correlated with the most severe sign of liver dysfunction, HE.
Negative_regulation (decrease) of Gc-globulin in liver
10) Confidence 0.39 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0 Pain Relevance 0
Patients with chronic liver disease had reduced Gc-globulin levels, but the reduction was less pronounced than in ALF.
Negative_regulation (reduced) of Gc-globulin in liver associated with liver disease and acute liver failure
11) Confidence 0.34 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 1.30 Pain Relevance 0.07
In my studies, I found serum Gc-globulin levels to be reduced in liver disease, most so in patients with acute liver failure (ALF).
Negative_regulation (reduced) of Gc-globulin in liver associated with liver disease and acute liver failure
12) Confidence 0.34 Published 2008 Journal Dan Med Bull Section Abstract Doc Link 19232164 Disease Relevance 0.86 Pain Relevance 0.26
BV caused a detectable increase in blood creatine kinase, glutamic oxaloacetic transaminase, and lactic dehydrogenase, as well as a decrease in the blood total protein albumin and globulin levels.
Negative_regulation (decrease) of globulin in blood
13) Confidence 0.15 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18543385 Disease Relevance 0.13 Pain Relevance 0.09
Thus treatment with SPP and SPE could significantly increase the albumin and decreased the globulin level in arthritic rats which indicates that SPP and SPE might have a suppressive action on the mediators of inflammation.
Negative_regulation (decreased) of globulin associated with inflammation and arthritis
14) Confidence 0.06 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2978115 Disease Relevance 1.10 Pain Relevance 0.28
Göker at al. demonstrated that coagulation factors II, V, VII, VIII, IX, X, XI, and XIII were not affected, and that plasma fibrinogen activity as well as total protein, albumin, and globulin levels were decreased by the addition of ABS to plasma [6,7].
Negative_regulation (decreased) of globulin in plasma
15) Confidence 0.01 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2993704 Disease Relevance 0.49 Pain Relevance 0.04

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