INT61648

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Context Info
Confidence 0.04
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.06
Pain Relevance 0.94

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cytosol (Gc) extracellular space (Gc) extracellular region (Gc)
Anatomy Mention Frequency
liver 3
Gc (Rattus norvegicus)
actin (Caenorhabditis elegans)
Pain Term Frequency Confidence Heat
Paracetamol 22 99.48 Very High Very High Very High
Multiple sclerosis 1 53.44 Quite High
Analgesic 1 25.00 Low Low
Disease Term Frequency Confidence Heat
Poisoning 10 98.36 Very High Very High Very High
Acute Liver Failure 11 98.30 Very High Very High Very High
Hepatotoxicity 5 96.68 Very High Very High Very High
Overdose 1 74.32 Quite High
Multiple Trauma 1 73.52 Quite High
Multiple Organ Failure 2 72.00 Quite High
Hepatic Encephalopathy 10 71.36 Quite High
Sepsis 1 68.24 Quite High
Pulmonary Disease 2 59.36 Quite High
Demyelinating Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum Gc-globulin and the degree of complexing with monomeric actin (complex ratio) in the initial phase of paracetamol (acetaminophen) intoxication and related this to the severity of liver necrosis and the clinical course.
Gc-globulin Binding (complexing) of actin in liver associated with paracetamol, hepatotoxicity and poisoning
1) Confidence 0.04 Published 1996 Journal Ugeskr. Laeg. Section Abstract Doc Link 8966827 Disease Relevance 0.65 Pain Relevance 0.36
In 77 patients with fulminant hepatic failure (FHF) (excluding patients treated with liver transplantation), admission levels of serum Gc-globulin and degree of complexing with monomeric actin (complex ratio) were determined to evaluate their predictive values in relation to survival/nonsurvival.
Gc-globulin Binding (complexing) of actin in liver associated with acute liver failure
2) Confidence 0.03 Published 1996 Journal Hepatology Section Abstract Doc Link 8666322 Disease Relevance 0.40 Pain Relevance 0.13
PATIENTS AND METHODS: Serial measurements of Gc-globulin and the proportion of Gc-globulin complexed to G-actin (complex ratio) were made on admission and every 3 h thereafter in eighteen consecutive patients with acetaminophen intoxication.
Gc-globulin Binding (complexed) of actin
3) Confidence 0.01 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0.10 Pain Relevance 0
The main function of Gc-globulin is to bind vitamin D and actin, which is released into the extracellular environment upon cell and tissue lysis.
Gc-globulin Binding (bind) of actin
4) Confidence 0.01 Published 2008 Journal Postepy Hig Med Dosw (Online) Section Abstract Doc Link 19002085 Disease Relevance 0.55 Pain Relevance 0.18
OBJECTIVES: To describe serum Gc-globulin and the extent to which it complexes with monomeric actin in the initial phase of acetaminophen (Paracetamol) intoxication and to relate this to the severity of liver necrosis and the clinical course.
Gc-globulin Binding (complexes) of actin in liver associated with paracetamol, hepatotoxicity and poisoning
5) Confidence 0.01 Published 1995 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 8590158 Disease Relevance 0.27 Pain Relevance 0.27
PATIENTS AND METHODS: Serial measurements of Gc-globulin and the proportion of Gc-globulin complexed to G-actin (complex ratio) were made on admission and every 3 h thereafter in eighteen consecutive patients with acetaminophen intoxication.
Gc-globulin Binding (complexed) of actin
6) Confidence 0.01 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 8590158 Disease Relevance 0.10 Pain Relevance 0

General Comments

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