INT6165

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 85
Total Number 89
Disease Relevance 18.39
Pain Relevance 51.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
brain 10
neurons 9
spinal 5
spinal cord 5
dorsal root ganglion 3
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 307 100.00 Very High Very High Very High
antagonist 287 100.00 Very High Very High Very High
gABA 161 100.00 Very High Very High Very High
nMDA receptor 143 100.00 Very High Very High Very High
Pain 100 100.00 Very High Very High Very High
Opioid 82 100.00 Very High Very High Very High
analgesia 49 100.00 Very High Very High Very High
opiate 34 100.00 Very High Very High Very High
Nerve growth factor 32 100.00 Very High Very High Very High
mu opioid receptor 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 80 100.00 Very High Very High Very High
Convulsion 5 100.00 Very High Very High Very High
Nociception 243 99.84 Very High Very High Very High
Spinal Cord Ischemia 6 99.84 Very High Very High Very High
Neuroblastoma 3 99.52 Very High Very High Very High
Ganglion Cysts 14 99.48 Very High Very High Very High
Gliosis 4 99.48 Very High Very High Very High
Diabetes Mellitus 10 99.36 Very High Very High Very High
Nicotine Addiction 6 99.36 Very High Very High Very High
Injury 28 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-Ala2-D-Leu5-enkephalin (DADLE) or D-Ala2-N-MePhe4-Gly5(ol)-enkephalin (DAGO), agonists selective for delta- and mu-opioid receptors, respectively, were affected by restraint stress.
Gene_expression (selective) of receptors associated with stress, mu opioid receptor, agonist and enkephalin
1) Confidence 0.58 Published 1986 Journal Brain Res. Section Abstract Doc Link 3015351 Disease Relevance 0.26 Pain Relevance 1.38
This study also suggests that the immobilizing action of isoflurane probably does not involve the GABA(A) receptor because antagonism of GABA(A) receptors for animals anesthetized with isoflurane produces results quantitatively and qualitatively similar to ketamine and markedly different from propofol.
Gene_expression (antagonism) of receptors associated with gaba, ketamine and isoflurane
2) Confidence 0.56 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12598250 Disease Relevance 0 Pain Relevance 0.99
In contrast, staining for mu opioid receptors using mu-selective antibodies revealed a discrete loss of mu opioid receptors localized ipsilateral to the nerve injury and specific for sections taken at the L6 level.
Gene_expression (using) of receptors in nerve associated with nervous system injury and mu opioid receptor
3) Confidence 0.52 Published 1998 Journal Brain Res. Section Abstract Doc Link 9622629 Disease Relevance 0.68 Pain Relevance 1.35
However, intense kappa immunoreactivity (ir) also appeared in a separate, morphologically distinct population of cells that did not express mu receptors.
Neg (not) Gene_expression (express) of receptors
4) Confidence 0.36 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546223 Disease Relevance 0.17 Pain Relevance 0.43
Although co-expression of mu and kappa receptors was also detected, the appearance of a separate population of kappa-expressing cells supports proposals that the contrasting and functionally antagonistic properties of mu and kappa receptors are due to expression in physiologically distinct cell types.
Gene_expression (expression) of receptors
5) Confidence 0.36 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546223 Disease Relevance 0.16 Pain Relevance 0.45
The results indicate that spinal cord ischemia reduces the expression of mu-opioid receptors in rat dorsal horn, which may be one of the underlying mechanisms of morphine insensitivity for treating acute allodynia after spinal ischemia.
Gene_expression (expression) of receptors in dorsal horn associated with allodynia, ischemia, dorsal horn, mu opioid receptor, morphine and spinal cord
6) Confidence 0.33 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094139 Disease Relevance 0.78 Pain Relevance 1.50
The present study examined the effects of spinal cord ischemia on the expression of mu-opioid receptors in rat dorsal spinal cord and the effects of intrathecal (i.t.) morphine on the acute mechanical allodynia that developed after spinal ischemia.
Gene_expression (expression) of receptors in spinal cord associated with allodynia, ischemia, mu opioid receptor, morphine, intrathecal and spinal cord
7) Confidence 0.33 Published 1999 Journal Neuroreport Section Abstract Doc Link 10094139 Disease Relevance 0.57 Pain Relevance 1.15
The data also suggest differences in the delta and mu receptors interacting in the modulation of antinociception and those involved in behavioral responses in the open field.
Gene_expression (interacting) of receptors associated with antinociception
8) Confidence 0.31 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972857 Disease Relevance 0 Pain Relevance 0.69
Although co-expression of mu and kappa receptors was also detected, the appearance of a separate population of kappa-expressing cells supports proposals that the contrasting and functionally antagonistic properties of mu and kappa receptors are due to expression in physiologically distinct cell types.
Gene_expression (expression) of receptors
9) Confidence 0.31 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546223 Disease Relevance 0.14 Pain Relevance 0.46
Cultures of aggregating guinea pig cerebellar cells were used to further study the factors regulating the expression of the three opioid receptors in this brain region.
Gene_expression (expression) of receptors in brain associated with opioid receptor
10) Confidence 0.22 Published 1989 Journal Dev. Neurosci. Section Abstract Doc Link 2553387 Disease Relevance 0 Pain Relevance 0.28
We also used Western blots to determine the expression level of the mu, delta and 5-HT(2A) receptors.
Spec (determine) Gene_expression (expression) of receptors
11) Confidence 0.19 Published 2003 Journal Peptides Section Abstract Doc Link 12732339 Disease Relevance 0 Pain Relevance 0.46
The phenotypic expression of the three opioid receptors kappa, mu and delta was determined in the rat and guinea pig cerebellum during ontogeny.
Spec (determined) Gene_expression (expression) of receptors in cerebellum associated with opioid receptor
12) Confidence 0.17 Published 1989 Journal Dev. Neurosci. Section Abstract Doc Link 2553387 Disease Relevance 0 Pain Relevance 0.13
The possibility that the development in vivo of cells expressing different opioid receptors is associated with the ontogeny of the endogenous opioid peptides is discussed.
Gene_expression (expressing) of receptors associated with endogenous opioid and opioid receptor
13) Confidence 0.17 Published 1989 Journal Dev. Neurosci. Section Abstract Doc Link 2553387 Disease Relevance 0 Pain Relevance 0.26
Kappa opioid receptors are expressed by interneurons in the CA1 area of the rat hippocampus: a correlated light and electron microscopic immunocytochemical study.
Gene_expression (expressed) of receptors in hippocampus associated with kappa opioid receptor and hippocampus
14) Confidence 0.17 Published 2000 Journal J. Chem. Neuroanat. Section Title Doc Link 11036240 Disease Relevance 0 Pain Relevance 0.43
Paradoxical and subtype-specific effects of opiate antagonists on the expression of opioid receptors in rat brain cultures.
Gene_expression (expression) of receptors in brain associated with antagonist, opioid receptor and opiate
15) Confidence 0.15 Published 1989 Journal J. Neurosci. Res. Section Title Doc Link 2540341 Disease Relevance 0 Pain Relevance 0.54
Cultures of aggregating fetal rat brain cells express mu, delta, and kappa opioid receptors.
Gene_expression (express) of receptors in brain associated with kappa opioid receptor
16) Confidence 0.15 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2540341 Disease Relevance 0 Pain Relevance 0.35
We have investigated the expression and regulation of kappa opiate receptors in rat spinal cord-dorsal root ganglion primary cocultures.
Spec (investigated) Gene_expression (expression) of receptors in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, opiate and spinal cord
17) Confidence 0.15 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.17 Pain Relevance 0.66
These data demonstrate that kappa opiate receptors are expressed at high concentration in spinal cord-dorsal root ganglion cocultures and that contrary to mu sites, kappa receptor density is less susceptible to modulation by chronic opiate treatment.
Gene_expression (expressed) of receptors in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, opiate and spinal cord
18) Confidence 0.15 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.22 Pain Relevance 1.28
Kappa receptors were visualized immunocytochemically with a previously produced and characterized monoclonal antibody, the mAb KA8 (Maderspach, K., Németh, K., Simon, J., Benyhe, S., Szûcs, M., Wollemann, M., 1991.
Gene_expression (visualized) of receptors
19) Confidence 0.15 Published 2000 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11036240 Disease Relevance 0 Pain Relevance 0.43
On the postganglionic cholinergic neurons, alpha-2-like receptors are present; it is not yet clear whether the pronounced effect of alpha-1 agonists on the cholinergic neuron activity is due to interaction with these receptors.
Gene_expression (present) of receptors in cholinergic neuron associated with agonist
20) Confidence 0.15 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6149310 Disease Relevance 0 Pain Relevance 0.39

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