INT61650

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Context Info
Confidence 0.52
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
spinal cord 1
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 79 100.00 Very High Very High Very High
Spinal cord 5 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
bradykinin 1 99.60 Very High Very High Very High
Neuropeptide 3 99.20 Very High Very High Very High
c fibre 1 83.20 Quite High
Antinociceptive 3 75.00 Quite High
cytokine 20 61.52 Quite High
Calcitonin gene-related peptide 1 50.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Targeted Disruption 42 92.08 High High
Cough 1 85.20 High High
Granuloma 92 64.72 Quite High
Ocular Hypertension 4 62.48 Quite High
Infection 12 50.00 Quite Low
Miosis 2 35.92 Quite Low
Anaplastic Astrocytoma 1 35.44 Quite Low
Schistosomiasis 2 24.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preprotachykinin protein is cleaved to form two active neuropeptides, SP and neurokinin A.
Protein_catabolism (cleaved) of Preprotachykinin associated with neuropeptide and substance p
1) Confidence 0.52 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.38 Pain Relevance 0.78
Substance P (SP), which is known as a pain transmitter or modulator in the spinal cord, was degraded by the synaptic membranes of the mouse spinal cord.
Protein_catabolism (degraded) of Substance P in spinal cord associated with pain, spinal cord and substance p
2) Confidence 0.21 Published 2004 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15148521 Disease Relevance 0.10 Pain Relevance 0.79
Angiotensin converting enzyme (ACE) -inhibitors inhibit degradation of inflammatory mediators substance P (SP) and bradykinin, which may further stimulate the synthesis of prostaglandins.
Protein_catabolism (degradation) of substance P associated with inflammatory mediators, bradykinin and substance p
3) Confidence 0.02 Published 1995 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 8590256 Disease Relevance 0.40 Pain Relevance 0.40

General Comments

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