INT61664

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Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 38
Total Number 41
Disease Relevance 16.45
Pain Relevance 25.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
synapse 3
muscle 2
neurons 2
cortex 2
dendrites 1
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 247 100.00 Very High Very High Very High
nMDA receptor 216 100.00 Very High Very High Very High
gABA 105 100.00 Very High Very High Very High
antagonist 102 100.00 Very High Very High Very High
Dextromethorphan 84 100.00 Very High Very High Very High
Neurotransmitter 29 100.00 Very High Very High Very High
mu opioid receptor 19 100.00 Very High Very High Very High
nMDA receptor antagonist 19 100.00 Very High Very High Very High
anesthesia 13 100.00 Very High Very High Very High
tramadol 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Thiamine Deficiency 6 99.92 Very High Very High Very High
Schizophrenia 61 99.84 Very High Very High Very High
Anxiety Disorder 137 99.80 Very High Very High Very High
Dyspepsia 42 99.76 Very High Very High Very High
Neuropathic Pain 169 99.68 Very High Very High Very High
Somatoform Disorder 72 99.64 Very High Very High Very High
Stress 198 99.44 Very High Very High Very High
Pain 222 99.20 Very High Very High Very High
Urological Neuroanatomy 19 99.08 Very High Very High Very High
Cancer Pain 1 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data will hopefully provide the impetus for development of novel compounds that use multiple approaches to modulate the activity of NR2B subunit-containing NMDA receptors, thus bringing to fruition the promise of therapeutic efficacy utilizing this approach.
Regulation (modulate) of NMDA associated with nmda receptor
1) Confidence 0.60 Published 2006 Journal Curr Opin Pharmacol Section Abstract Doc Link 16376149 Disease Relevance 0.61 Pain Relevance 0.72
Protein tyrosine phosphorylation regulates NMDA channel receptor activity.
Regulation (regulates) of NMDA
2) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.50 Pain Relevance 1.24
A great number of studies have addressed the role of NMDA receptors and metabotropic glutamate receptors in synapses between primary afferent fibers and spinal neurons.
Regulation (role) of NMDA in synapses associated with primary afferent fibers, glutamate receptor and nmda receptor
3) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.52 Pain Relevance 0.82
Therefore, a direct effect of HP or its metabolites on NMDA receptors might be ruled out as an explanation for their antiallodynic effect in the present study.
Regulation (metabolites) of NMDA associated with nmda receptor and antiallodynic
4) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.14 Pain Relevance 0.74
Figure 8B illustrates that blocking NMDA receptors did not alter the slope of the curve (and thus the stability of the system) and instead caused a uniform reduction in the fout/fout0 ratio, which is similar to the effect of presynaptic changes described in Figure 7.
Neg (not) Regulation (alter) of NMDA associated with nmda receptor
5) Confidence 0.44 Published 2006 Journal Mol Pain Section Body Doc Link PMC1624821 Disease Relevance 0.16 Pain Relevance 0.23
In the latter study, TDS stress induced a significant down-regulation of hippocampal NMDA receptors.
Regulation (regulation) of NMDA associated with stress and nmda receptor
6) Confidence 0.44 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.98 Pain Relevance 0.56
It is of major significance that TDS stress-induced activation of hippocampal iNOS and the down-regulation of NMDA receptors described above are associated with a significant attenuation of total hippocampal GABA (Harvey et al 2004).
Regulation (regulation) of NMDA associated with stress, gaba and nmda receptor
7) Confidence 0.44 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.62 Pain Relevance 0.61
The degree of reduction in allodynia and prolonged relief after introduction of ketamine in all our patients emphasizes the role of NMDA antagonists in reorganization of plastic changes at the peripheral, spinal cord and cortical level.
Regulation (role) of NMDA in spinal cord associated with ketamine, allodynia, antagonist and spinal cord
8) Confidence 0.44 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2584055 Disease Relevance 0.71 Pain Relevance 0.91
Therefore, the antiallodynic effects of HP and its metabolites might be explained by their ability to indirectly modulate NMDA-mediated effects through an action on ?
Regulation (modulate) of NMDA associated with antiallodynic
9) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0 Pain Relevance 0.52
We tested the effects of tramadol and its M1 metabolite (0.1-100 microM) on human recombinant neurotransmitter-gated ion channels, including glycine, gamma-aminobutyric acid(A) (GABA(A)), and N-methyl-D-aspartate (NMDA) receptors, expressed in Xenopus oocytes.
Regulation (effects) of NMDA in oocytes associated with tramadol, gaba and neurotransmitter
10) Confidence 0.44 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15845694 Disease Relevance 0 Pain Relevance 1.31
[The role of the NMDA-receptor blocker and stimulator ketamine and glycine in the development of a neuropathic pain syndrome].
Regulation (role) of NMDA associated with pain, ketamine, syndrome and neuropathic pain
11) Confidence 0.44 Published 1997 Journal Eksp Klin Farmakol Section Title Doc Link 9376747 Disease Relevance 0.46 Pain Relevance 0.73
Prior in vivo cocaine administration did not alter the NMDA-evoked dopamine release.
Neg (not) Regulation (alter) of NMDA associated with dopamine and cocaine
12) Confidence 0.44 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729284 Disease Relevance 0.09 Pain Relevance 0.94
The aim of the present study was to investigate the effect of the NMDA-receptor antagonist dextromethorphan on pain after minor gynaecological surgery, and to evaluate a potential additive effect with ibuprofen.
Spec (investigate) Regulation (effect) of NMDA-receptor associated with pain, antagonist and dextromethorphan
13) Confidence 0.44 Published 2000 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 10939702 Disease Relevance 0.45 Pain Relevance 0.55
One of the new family of NMDA receptor antagonists, such as DETC-MESO, which regulate the redox site of NMDA receptors, may prove to be the drug of choice for treating alcoholism as well as many neurological diseases.
Regulation (regulate) of NMDA associated with alcohol addiction, nmda receptor antagonist, neurological disease and nmda receptor
14) Confidence 0.44 Published 2001 Journal J. Biomed. Sci. Section Abstract Doc Link 11173971 Disease Relevance 1.51 Pain Relevance 0.69
Agents that directly inactivate the NMDA synapse necessarily have anesthetic properties; agents that do not directly affect the NMDA synapse will exert an anesthetic action, if they inhibit NMDA-dependent processes.
Neg (not) Regulation (affect) of NMDA in synapse
15) Confidence 0.44 Published 1998 Journal Toxicol. Lett. Section Abstract Doc Link 10049147 Disease Relevance 0.08 Pain Relevance 0.18
Thus, further targets for the indirect control of NMDA induced activity are possible.
Regulation (control) of NMDA
16) Confidence 0.43 Published 1997 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9061093 Disease Relevance 0.29 Pain Relevance 1.07
It is important to note that the spatial and temporal patterns of responses in primary somatosensory cortex (SI) to repetitive vibrotactile stimulation are largely dependent on the complex interplay of GABA-mediated inhibition [13] and NMDAR activation [14] in addition to other neural processes [15,16].
Regulation (dependent) of NMDAR in neural associated with gaba and primary somatosensory cortex
17) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553799 Disease Relevance 0 Pain Relevance 0.36
Accordingly, the effect of NMDA on afferent activity as well as the effect of locally administered NMDA receptor antagonists on glutamate-evoked afferent discharges in acutely anesthetized rats and muscle pain in human subjects was examined.
Regulation (effect) of NMDA in muscle associated with pain, glutamate, nmda receptor antagonist and myalgia
18) Confidence 0.38 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12815021 Disease Relevance 0.35 Pain Relevance 1.08
Alterations of glutamatergic synaptic function involving both NMDA and kainate receptor subclasses could contribute to the pathogenesis of neurological dysfunction in Wernicke's Encephalopathy in humans.
Regulation (Alterations) of NMDA associated with anesthesia and encephalopathy
19) Confidence 0.34 Published 1995 Journal Neurochem. Res. Section Abstract Doc Link 8746800 Disease Relevance 0.54 Pain Relevance 0.43
Accordingly, the effect of NMDA on afferent activity as well as the effect of locally administered NMDA receptor antagonists on glutamate-evoked afferent discharges in acutely anesthetized rats and muscle pain in human subjects was examined.
Regulation (effect) of NMDA in muscle associated with pain, glutamate, nmda receptor antagonist and myalgia
20) Confidence 0.33 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12815021 Disease Relevance 0.35 Pain Relevance 1.08

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