INT61665

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.79
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 2.26
Pain Relevance 23.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 2
ovary 2
PC-12 1
hepatocytes 1
striatum 1
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 132 100.00 Very High Very High Very High
cocaine 36 99.82 Very High Very High Very High
tolerance 55 99.78 Very High Very High Very High
Opioid 42 99.72 Very High Very High Very High
Antinociceptive 57 99.58 Very High Very High Very High
Hippocampus 8 99.52 Very High Very High Very High
Dopamine 3934 99.48 Very High Very High Very High
Morphine 56 99.44 Very High Very High Very High
Neuropeptide 9 99.36 Very High Very High Very High
agonist 161 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Tics 10 97.80 Very High Very High Very High
Pain 51 97.76 Very High Very High Very High
Ganglion Cysts 2 93.84 High High
Hyperalgesia 25 93.24 High High
Pheochromocytoma 3 87.40 High High
Inflammatory Pain 10 86.56 High High
INFLAMMATION 23 85.44 High High
Fistula 19 77.76 Quite High
Nociception 17 74.08 Quite High
Neuropathic Pain 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neuropeptide thyrotropin-releasing hormone (TRH), which also depolarizes and increases the RN of HMs, occluded the response of HMs to NE. 6.
Phosphorylation (depolarizes) of TRH in HMs associated with neuropeptide
1) Confidence 0.79 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 8592184 Disease Relevance 0 Pain Relevance 0.36
A large body of evidence supports the key role of DARPP-32-dependent signalling in mediating the actions of multiple drugs of abuse, including cocaine, which, when acutely administered, increases the Thr(34) phosphorylation of DARPP-32 in the striatal and cortical areas.
Phosphorylation (phosphorylation) of Thr in body associated with cocaine
2) Confidence 0.27 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.50
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
Phosphorylation (phosphorylation) of Thr in brain associated with analgesic, agonist, kappa opioid receptor and cocaine
3) Confidence 0.27 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.81
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Phosphorylation (phosphorylation) of Thr in hippocampus associated with hippocampus and cocaine
4) Confidence 0.27 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
In this study, we have examined the contribution of the kappa opioid system to the regulation of DARPP-32 phosphorylation at Thr(34), following acute cocaine administration, in selected rat brain areas.
Phosphorylation (phosphorylation) of Thr in brain associated with opioid and cocaine
5) Confidence 0.27 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.64
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Phosphorylation (phosphorylation) of Thr in prefrontal associated with hippocampus and cocaine
6) Confidence 0.09 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Phosphorylation (phosphorylation) of Thr in caudate putamen associated with hippocampus and cocaine
7) Confidence 0.09 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
We show here that slow calcium transients, as occurs with calcium release from intracellular stores, are able to dephosphorylate Thr34.
Phosphorylation (dephosphorylate) of Thr34
8) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14
Nonetheless, during transient dopamine inputs alone, the loop acts as a sink, in which binding of PKAc to PP2A or phosphoThr75 actually decreases the amount of free PKAc, and thereby decreases the ability of PKAc to phosphorylate DARPP-32 on Thr34.
Phosphorylation (phosphorylate) of Thr34 associated with dopamine
9) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.08
It is known that phosphorylation of one site can affect phosphorylation rates on other sites of the molecule [72,73]; it therefore seems unlikely that the phosphorylation of Thr34 is independent of phosphorylation of Thr75 [15].
Phosphorylation (phosphorylation) of Thr34
10) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.06
We developed a computer model of the biochemical reaction pathways involved in the phosphorylation of DARPP-32 on Thr34 and Thr75.
Phosphorylation (phosphorylation) of Thr34
11) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Abstract Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.26
When phosphorylated at Thr34, DARPP-32 is a potent inhibitor of PP1 [14], whereas when phosphorylated at Thr75 DARPP-32 inhibits protein kinase A (PKA) [15].
Phosphorylation (phosphorylated) of Thr34
12) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.38
Thr34 is dephosphorylated by PP2B when this phosphatase is bound to Ca4CaM [16]; in contrast, Thr75 is dephosphorylated by PP2A [65].
Phosphorylation (dephosphorylated) of Thr34
13) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.10
It is known, however, that phosphorylation of Ser 102 and Ser 137 influences the rate of phosphorylation of Thr34 [72,73], indicating that intramolecular mechanisms are important.
Phosphorylation (phosphorylation) of Thr34
14) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
Thr34 is phosphorylated by PKA and dephosphorylated by protein phosphatase 2B (PP2B or calcineurin) [16,21] whereas Thr75 is phosphorylated by the cyclin-dependent kinase 5 (cdk5) and dephosphorylated mainly by PP2A [15,17].
Phosphorylation (dephosphorylated) of Thr34
15) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.42
Thr34 is phosphorylated by PKA and dephosphorylated by protein phosphatase 2B (PP2B or calcineurin) [16,21] whereas Thr75 is phosphorylated by the cyclin-dependent kinase 5 (cdk5) and dephosphorylated mainly by PP2A [15,17].
Phosphorylation (phosphorylated) of Thr34
16) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.42
Experiments have not shown directly whether the phosphorylation of Thr34 influences the rate of phosphorylation of Thr75.
Phosphorylation (phosphorylation) of Thr34
17) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0
If the level of PP2B is decreased to 10% of control (simulating the effect of cyclosporin A for 20 min [27]), the effect of calcium on Thr34 phosphorylation is eliminated.
Phosphorylation (phosphorylation) of Thr34
18) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.17
The catalytic subunit of PKA catalyses phosphorylation of DARPP-32 at Thr34 [73,107]; Cdk5 catalyses phosphorylation of DARPP-32 at Thr75 [15].
Phosphorylation (phosphorylation) of Thr34
19) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.05
Thus, for simplicity, simultaneous phosphorylation on both Thr34 and Thr75 are excluded.
Phosphorylation (phosphorylation) of Thr34
20) Confidence 0.05 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox