INT61674

Context Info Confidence 0.01 First Reported 1995 Last Reported 1995 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 1.62

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Gpm6a (Rattus norvegicus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 1 100.00 analgesia 8 99.44 Morphine 8 99.24 Central grey 1 72.96 Enkephalin 3 70.40 Analgesic 3 68.84 narcan 1 25.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 72.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results confirm the prior association of Gi alpha 2 with morphine analgesia and strongly suggests that M6G acts through a different opioid receptor, as revealed by its insensitivity towards the MOR-1 antisense probe and differential sensitivity towards G-protein alpha subunit antisense oligodeoxynucleotides.

M6G Regulation (acts) of opioid receptor associated with opioid receptor, analgesia and morphine

1) Confidence 0.01 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8592651 Disease Relevance 0.07 Pain Relevance 1.62

General Comments

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