INT61684

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.31
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
fibroblasts 2
Cleavage 1
sympathetic 1
parathyroid 1
urine 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 19 99.36 Very High Very High Very High
Rsd 4 99.10 Very High Very High Very High
Pain 16 94.92 High High
Osteoarthritis 135 94.24 High High
pulpitis 1 84.32 Quite High
backache 6 82.40 Quite High
corticosteroid 13 80.76 Quite High
rheumatoid arthritis 58 77.60 Quite High
alcohol 2 68.96 Quite High
Inflammation 64 68.20 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 80 100.00 Very High Very High Very High
Reflex Sympathetic Dystrophy 2 99.10 Very High Very High Very High
Osteogenesis Imperfecta 2 99.08 Very High Very High Very High
Ganglion Cysts 2 98.72 Very High Very High Very High
Hepatitis 16 97.36 Very High Very High Very High
Increased Venous Pressure Under Development 14 95.92 Very High Very High Very High
Osteoporosis 89 95.52 Very High Very High Very High
Recurrence 1 95.36 Very High Very High Very High
Pain 11 94.92 High High
Hepatitis B Virus Infection 9 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical tests were normal except for an increase in urinary excretion of the N-telopeptide cross-linking region of type I collagen (NTx).
Localization (excretion) of type I collagen
1) Confidence 0.73 Published 2000 Journal J. Bone Miner. Res. Section Abstract Doc Link 11028460 Disease Relevance 0.33 Pain Relevance 0.33
Except for the patient with mild osteogenesis imperfecta, cultured dermal fibroblasts synthesized and exported normal Type I collagen.
Localization (exported) of Type I collagen in fibroblasts associated with osteogenesis imperfecta
2) Confidence 0.69 Published 1995 Journal QJM Section Abstract Doc Link 8593546 Disease Relevance 1.09 Pain Relevance 0.19
Type I collagen was localized evenly in the stones, indicating that it is a major matrix component of pulp stones.
Localization (localized) of Type I collagen
3) Confidence 0.47 Published 2001 Journal J Endod Section Abstract Doc Link 11485265 Disease Relevance 0.36 Pain Relevance 0.08
These data come from the population-based Chingford study, conducted in 216 women in whom urine from three time points was assayed for urinary collagen cross-link excretion (urine C-telopeptide of type I collagen (CTx) and NTx).
Localization (excretion) of type I collagen in urine
4) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 1.03 Pain Relevance 0.37
OBJECTIVE: To evaluate the efficacy of intravenous (i.v.) clodronate in patients with reflex sympathetic dystrophy syndrome (RSDS) and to assess the urinary excretion of type I collagen crosslinked N-telopeptide (NTx) before and after the treatment.
Localization (excretion) of type I collagen in sympathetic associated with rsd
5) Confidence 0.38 Published 2000 Journal J. Rheumatol. Section Abstract Doc Link 10852274 Disease Relevance 0.17 Pain Relevance 0.17
Procollagen I staining localized intracellularly to fibroblast-shaped cells within this alpha-SMA/SMMHC-positive scirrhous region.
Localization (localized) of Procollagen I in fibroblast
6) Confidence 0.33 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.07 Pain Relevance 0
The type I collagen telopeptide fragments, C-telopeptide crosslaps of type I collagen (CTX-1) and C-terminal telopeptide of type I collagen (1CTP), are currently considered as the most sensitive markers of bone resorption and are released from bone type I collagen by different enzymatic pathways.
Localization (released) of type I collagen associated with hypercalcemia
7) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.73 Pain Relevance 0.07
The type I collagen telopeptide fragments, C-telopeptide crosslaps of type I collagen (CTX-1) and C-terminal telopeptide of type I collagen (1CTP), are currently considered as the most sensitive markers of bone resorption and are released from bone type I collagen by different enzymatic pathways.
Localization (released) of type I collagen associated with hypercalcemia
8) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.69 Pain Relevance 0.07
Immunohistochemical localization of types I and II collagen, chondroitin sulfate, decorin and keratan sulfate utilized antibodies used techniques described previously [15,25].
Localization (localization) of II collagen
9) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2443126 Disease Relevance 0 Pain Relevance 0.03
Primers for the genes encoding a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS)-5 (aggrecanase-2), matrix metalloproteinase (MMP)-3 (stromelysin), osteocalcin, alkaline phosphatase and type I collagen ?
Localization (alkaline phosphatase) of type I collagen associated with metalloproteinase
10) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.07 Pain Relevance 0.15
Cleavage of type I collagen results in release of C-terminal telopeptide of collagen type I (CTX-I) [20,21], which has been used extensively as a surrogate measure of bone resorption for in vitro, preclinical and clinical studies [20,22].
Localization (Cleavage) of type I collagen in Cleavage associated with hypercalcemia
11) Confidence 0.07 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 1.02 Pain Relevance 0.38
Bone-specific alkaline phosphatase and urinary N-terminal telopeptide of type I collagen normalized by creatinine were significantly more reduced in the risedronate treated group than in the control group after both 6 and 12 months.
Localization (alkaline phosphatase) of type I collagen
12) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685258 Disease Relevance 1.39 Pain Relevance 0.03
Urinary excretion of type I collagen cross-linked N-telopeptide and serum bone-specific alkaline phosphatase analysis to determine the correlation of age and back-pain related changes in elderly women.
Localization (excretion) of type I collagen associated with pain
13) Confidence 0.04 Published 2005 Journal J. Bone Miner. Metab. Section Title Doc Link 16261458 Disease Relevance 0.53 Pain Relevance 0.37
BMD, bone mineral density; IFN, interferon; PTH, parathyroid hormone; ALP, alkaline phosphates; CTX, C-terminal cross-linking telopeptide of type I collagen; IL, interleukin; DEXA, dual-energy x-ray absorptiometry; HBsAg, hepatitis B surface antigen; Anti-HBc, anticore IgG antibodies; HBV, Hepatitis B virus

Competing interests

Localization (telopeptide) of type I collagen in parathyroid associated with hepatitis b virus infection and hepatitis
14) Confidence 0.04 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1242225 Disease Relevance 0.67 Pain Relevance 0.03
At immunohistochemistry, we detected the location of type I and II collagen, S-100 protein, and fibronectin.
Localization (location) of type I and II collagen
15) Confidence 0.04 Published 2010 Journal Strategies Trauma Limb Reconstr Section Body Doc Link PMC2918740 Disease Relevance 0 Pain Relevance 0
After secretion procollagen is converted to collagen by specific enzymes, the endopeptidases procollagen N- and C-proteinases [35].
Localization (secretion) of procollagen
16) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.09 Pain Relevance 0
Collagen is produced and secreted as procollagen, which consists of large extra domains known as the procollagen propeptides.
Localization (secreted) of procollagen
17) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.10 Pain Relevance 0
It has been generally assumed that these procollagen propeptides, thus released to the extracellular space, would rapidly be eliminated locally.
Localization (released) of procollagen
18) Confidence 0.02 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.08 Pain Relevance 0
During embryogenesis, type IIA procollagen is localized around cells of the developing ganglion cell layer [30], playing a role in guiding the axonal processes of the developing retinal ganglion cells as they traverse the retinal surface and converge to form the optic nerve bundle [31].
Localization (localized) of procollagen in retinal ganglion cells associated with ganglion cysts
19) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.82 Pain Relevance 0
Furthermore, EGCG inhibited ethanol-induced type-I procollagen production and collagen secretion.
Localization (secretion) of procollagen
20) Confidence 0.00 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox