INT61685

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Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.05
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
pulmonary artery 2
cerebellum 1
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 10 99.60 Very High Very High Very High
midbrain 2 98.08 Very High Very High Very High
Substantia nigra 2 96.00 Very High Very High Very High
Thalamus 2 92.40 High High
Raphe 2 89.44 High High
Arthritis 1 87.36 High High
chemokine 1 80.52 Quite High
amygdala 2 79.64 Quite High
potassium channel 2 77.56 Quite High
opioid receptor 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 215 100.00 Very High Very High Very High
Peripheral Arterial Disease 15 99.90 Very High Very High Very High
Hypoxia 68 99.16 Very High Very High Very High
Systemic Sclerosis 4 98.96 Very High Very High Very High
Adhesions 2 98.72 Very High Very High Very High
Obesity 18 97.48 Very High Very High Very High
Nociception 2 95.64 Very High Very High Very High
Hypertrophy 37 91.16 High High
Myocardial Infarction 58 90.80 High High
Stroke 1 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of cofactors required for the PAH activity, physiologically by hypoxia or pharmacologically by intracellular iron chelation, increases the HIF-1?
Positive_regulation (required) of Gene_expression (activity) of PAH associated with hypoxia
1) Confidence 0.43 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.38 Pain Relevance 0.10
However, it has not been shown whether quantification of the pulmonary artery flow deceleration (PAD) is useful for detecting PAH or measuring its severity.
Spec (whether) Positive_regulation (useful) of Gene_expression (detecting) of PAH in pulmonary artery associated with pulmonary hypertension and peripheral arterial disease
2) Confidence 0.38 Published 2010 Journal Int J Cardiovasc Imaging Section Body Doc Link PMC2868165 Disease Relevance 0.87 Pain Relevance 0.04
Intratracheal transfer of the human prostacyclin synthase (PGIS) gene to rats with MCT-induced PAH augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced PAH, and improved survival in MCT rats [56].
Positive_regulation (transfer) of Gene_expression (transfer) of PAH associated with pulmonary hypertension
3) Confidence 0.33 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.76 Pain Relevance 0.04
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

Positive_regulation (tool) of Gene_expression (stage) of PAH associated with pulmonary hypertension, obesity and systemic sclerosis
4) Confidence 0.17 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.84 Pain Relevance 0.04
Only increases in glucose utilization were produced by D-Ala2; MePhe4, Gly-ol5-enkephalin in brain regions involved in motor control, including the globus pallidus, the substantia nigra, pars reticulata, the nucleus ruber and the cerebellum, and brain regions involved in visual processing--the visual cortex and superior colliculus deep layer.
Positive_regulation (increases) of Gene_expression (produced) of MePhe4 in brain associated with substantia nigra and enkephalin
5) Confidence 0.05 Published 1995 Journal Brain Res. Section Abstract Doc Link 8593578 Disease Relevance 0.10 Pain Relevance 0.79
Only increases in glucose utilization were produced by D-Ala2; MePhe4, Gly-ol5-enkephalin in brain regions involved in motor control, including the globus pallidus, the substantia nigra, pars reticulata, the nucleus ruber and the cerebellum, and brain regions involved in visual processing--the visual cortex and superior colliculus deep layer.
Positive_regulation (increases) of in cerebellum Gene_expression (produced) of MePhe4 in brain associated with substantia nigra and enkephalin
6) Confidence 0.02 Published 1995 Journal Brain Res. Section Abstract Doc Link 8593578 Disease Relevance 0.10 Pain Relevance 0.79

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