INT61686

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Context Info
Confidence 0.24
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.74
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
brain 3
blood 2
cerebral cortex 2
whiskers 2
cerebellum 1
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 136 100.00 Very High Very High Very High
cerebral cortex 37 99.32 Very High Very High Very High
Enkephalin 16 99.28 Very High Very High Very High
midbrain 2 98.08 Very High Very High Very High
Substantia nigra 3 95.68 Very High Very High Very High
Thalamus 4 92.40 High High
Raphe 2 89.44 High High
amygdala 4 79.64 Quite High
Inflammation 1 77.88 Quite High
opioid receptor 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 91 98.56 Very High Very High Very High
Nociception 2 95.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 304 90.88 High High
Borderline Personality 1 84.68 Quite High
INFLAMMATION 1 77.88 Quite High
Syndrome 29 76.80 Quite High
Tourette's Syndrome 17 73.04 Quite High
Peripheral Arterial Disease 19 66.04 Quite High
Traumatic Stress Disorders 1 50.68 Quite High
Cognitive Disorder 13 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat N2, the D2 and D1 whiskers were trimmed by approximately 2 mm after each day's measurement, while ?
Positive_regulation (trimmed) of Gene_expression (whiskers) of D2 in whiskers
1) Confidence 0.24 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2525689 Disease Relevance 0.07 Pain Relevance 0
Gene expression studies using real time PCR showed an increased expression of dopamine D1 and D2 receptor in the cerebral cortex of diabetic rats.
Positive_regulation (increased) of Gene_expression (expression) of D2 in cerebral cortex associated with dopamine, diabetes mellitus and cerebral cortex
2) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.72 Pain Relevance 0.46
Dopamine D2 receptors, regional blood flow, and response to methylphenidate
Positive_regulation (response) of Gene_expression (receptors) of D2 in blood associated with dopamine
3) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.76 Pain Relevance 0.10
Only increases in glucose utilization were produced by D-Ala2; MePhe4, Gly-ol5-enkephalin in brain regions involved in motor control, including the globus pallidus, the substantia nigra, pars reticulata, the nucleus ruber and the cerebellum, and brain regions involved in visual processing--the visual cortex and superior colliculus deep layer.
Positive_regulation (increases) of Gene_expression (produced) of D-Ala2 in brain associated with substantia nigra and enkephalin
4) Confidence 0.02 Published 1995 Journal Brain Res. Section Abstract Doc Link 8593578 Disease Relevance 0.10 Pain Relevance 0.79
Only increases in glucose utilization were produced by D-Ala2; MePhe4, Gly-ol5-enkephalin in brain regions involved in motor control, including the globus pallidus, the substantia nigra, pars reticulata, the nucleus ruber and the cerebellum, and brain regions involved in visual processing--the visual cortex and superior colliculus deep layer.
Positive_regulation (increases) of in cerebellum Gene_expression (produced) of D-Ala2 in brain associated with substantia nigra and enkephalin
5) Confidence 0.01 Published 1995 Journal Brain Res. Section Abstract Doc Link 8593578 Disease Relevance 0.10 Pain Relevance 0.79

General Comments

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