INT61706

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 10.09
Pain Relevance 11.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) response to stress (Gal)
cytoplasm (Gal)
Anatomy Link Frequency
dorsal root ganglia 15
neurons 6
spinal cord 3
PDL 2
hypothalamus 2
Gal (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 66 100.00 Very High Very High Very High
Sciatic nerve 33 100.00 Very High Very High Very High
Neuropeptide 26 100.00 Very High Very High Very High
Inflammation 23 100.00 Very High Very High Very High
Spinal cord 18 100.00 Very High Very High Very High
fluoxetine 7 100.00 Very High Very High Very High
Cholecystokinin 2 99.80 Very High Very High Very High
dorsal root ganglion 44 99.60 Very High Very High Very High
Root ganglion neuron 12 99.40 Very High Very High Very High
allodynia 1 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 29 100.00 Very High Very High Very High
Obesity 3 99.84 Very High Very High Very High
Nociception 13 99.74 Very High Very High Very High
Ganglion Cysts 56 99.60 Very High Very High Very High
Neuropathic Pain 16 98.44 Very High Very High Very High
INFLAMMATION 19 97.28 Very High Very High Very High
Colitis 2 97.00 Very High Very High Very High
Diverticulitis 1 96.64 Very High Very High Very High
Pain 11 96.32 Very High Very High Very High
Abdominal Pain 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Galanin expression in primary sensory neurons seems to be differentially regulated following partial and complete sciatic nerve injuries.
Regulation (regulated) of Gene_expression (expression) of Galanin in primary sensory neurons associated with nervous system injury and sciatic nerve
1) Confidence 0.62 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219977 Disease Relevance 0.70 Pain Relevance 0.43
These results indicate that reduced food intake affects the expression of NPY, Gal and Leu-enk not only in the relevant hypothalamic neuroendocrine centres, but also in the lateral septal area.
Regulation (affects) of Gene_expression (expression) of Gal in septal area
2) Confidence 0.61 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196194 Disease Relevance 0 Pain Relevance 0.04
Androgens regulate the sexually dimorphic production of co-contained galanin and cholecystokinin in lumbar laminae VII and X neurons.
Regulation (regulate) of Gene_expression (production) of galanin in neurons associated with cholecystokinin
3) Confidence 0.60 Published 2006 Journal Brain Res. Section Title Doc Link 16764834 Disease Relevance 0.08 Pain Relevance 0.24
These results show that galanin expression in DRGs and spinal cord is differentially regulated by different degrees of nerve constriction and further support its modulatory role on neuropathic pain.
Regulation (regulated) of Gene_expression (expression) of galanin in DRGs associated with neuropathic pain and spinal cord
4) Confidence 0.60 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17693056 Disease Relevance 0.26 Pain Relevance 0.49
Effects of fluoxetine administration on regional galanin expression in obese Zucker rat hypothalamus.
Regulation (Effects) of Gene_expression (expression) of galanin in hypothalamus associated with obesity and fluoxetine
5) Confidence 0.54 Published 2004 Journal Nutr Neurosci Section Title Doc Link 15526991 Disease Relevance 0.59 Pain Relevance 0.52
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis.
Regulation (Prolonged) of Gene_expression (expression) of galanin in enteric nerves associated with colitis and neuropeptide
6) Confidence 0.44 Published 2008 Journal Neurogastroenterol. Motil. Section Title Doc Link 18208479 Disease Relevance 0.69 Pain Relevance 0.49
No overlap of sensitivity to capsaicin and expression of galanin in rat dorsal root ganglion neurons after axotomy.
Regulation (sensitivity) of Gene_expression (expression) of galanin in dorsal root ganglion associated with ganglion cysts, qutenza and root ganglion neuron
7) Confidence 0.44 Published 2003 Journal Exp Brain Res Section Title Doc Link 12955388 Disease Relevance 0.36 Pain Relevance 0.86
Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.
Regulation (Regulation) of Gene_expression (expression) of galanin in dorsal root ganglia associated with inflammation and spinal cord
8) Confidence 0.41 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9928186 Disease Relevance 0.75 Pain Relevance 0.59
Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.
Regulation (Regulation) of Gene_expression (expression) of galanin in dorsal root ganglia associated with inflammation and spinal cord
9) Confidence 0.41 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9928186 Disease Relevance 0.74 Pain Relevance 0.59
We investigated the effects of partial sciatic nerve injuries on galanin expression in primary sensory neurons, and compared this effect with that after complete sciatic nerve injury.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of galanin in sciatic nerve associated with nervous system injury and sciatic nerve
10) Confidence 0.27 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219977 Disease Relevance 0.70 Pain Relevance 0.69
Our findings suggest that RTX can cause changes (messenger plasticity) in galanin, VIP and NOS expression in capsaicin-sensitive sensory neurones of the rat, similar to those described following axotomy.
Regulation (changes) of Gene_expression (expression) of galanin associated with qutenza
11) Confidence 0.26 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.20
We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar.
Spec (examining) Regulation (effect) of Gene_expression (expression) of GAL in PDL
12) Confidence 0.26 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12939349 Disease Relevance 0.10 Pain Relevance 0.18
In this study, we have evaluated the effect of MSC administration on the expression of the neuropeptides galanin and NPY, as well as the NPY Y(1)-receptor (Y(1)R) in DRG neurons.
Regulation (effect) of Gene_expression (expression) of galanin in neurons associated with neuropeptide
13) Confidence 0.26 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19168218 Disease Relevance 0.33 Pain Relevance 0.45
These results show that galanin expression in DRGs and spinal cord is differentially regulated by different degrees of nerve constriction and further support its modulatory role on neuropathic pain.
Regulation (regulated) of in spinal cord Gene_expression (expression) of galanin in DRGs associated with neuropathic pain and spinal cord
14) Confidence 0.20 Published 2008 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17693056 Disease Relevance 0.26 Pain Relevance 0.49
Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.
Regulation (Regulation) of in spinal cord Gene_expression (expression) of galanin in dorsal root ganglia associated with inflammation and spinal cord
15) Confidence 0.14 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9928186 Disease Relevance 0.74 Pain Relevance 0.59
Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation.
Regulation (Regulation) of in spinal cord Gene_expression (expression) of galanin in dorsal root ganglia associated with inflammation and spinal cord
16) Confidence 0.14 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9928186 Disease Relevance 0.75 Pain Relevance 0.59
It is not known to what extent galanin and its receptor GalR2 expression is regulated by capsaicin in DRG neurons.
Regulation (regulated) of Gene_expression (expression) of galanin in neurons associated with dorsal root ganglion and qutenza
17) Confidence 0.03 Published 2008 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 18553211 Disease Relevance 0.88 Pain Relevance 1.10
Effects of acute (4 h) or chronic (4 d) treatment with capsaicin at different concentrations (0.01, 0.1, 1 micromol/L) on galanin and GalR2 expression in primary cultured DRG neurons were investigated in the present study.
Spec (investigated) Regulation (Effects) of Gene_expression (expression) of galanin in DRG associated with dorsal root ganglion and qutenza
18) Confidence 0.03 Published 2008 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 18553211 Disease Relevance 0.87 Pain Relevance 1.22
The possible significance of the neurotransmission of nociceptive information involved in galanin or GalR2 expression caused by capsaicin is still to be clarified.
Regulation (involved) of Gene_expression (expression) of galanin associated with nociception and qutenza
19) Confidence 0.03 Published 2008 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 18553211 Disease Relevance 0.44 Pain Relevance 1.06
Regulation of galanin and galanin receptor 2 expression by capsaicin in primary cultured dorsal root ganglion neurons.
Regulation (Regulation) of Gene_expression (expression) of galanin in dorsal root ganglion associated with ganglion cysts, qutenza and root ganglion neuron
20) Confidence 0.03 Published 2008 Journal In Vitro Cell. Dev. Biol. Anim. Section Title Doc Link 18553211 Disease Relevance 0.86 Pain Relevance 1.13

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