INT61733

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Context Info
Confidence 0.26
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.99
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tnf) plasma membrane (Tlr4, Tnf) intracellular (Tlr4, Tnf)
cell proliferation (Tnf) extracellular space (Tnf) extracellular region (Tnf)
Anatomy Link Frequency
macrophages 2
Tlr4 (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
Morphine 1 98.36 Very High Very High Very High
cytokine 14 95.40 Very High Very High Very High
antagonist 5 92.60 High High
qutenza 2 92.60 High High
Opioid 3 92.16 High High
Inflammation 7 90.72 High High
substance P 1 75.00 Quite High
opioid receptor 1 74.80 Quite High
Inflammatory response 1 69.44 Quite High
Disease Link Frequency Relevance Heat
Stress 10 97.16 Very High Very High Very High
Shock 2 94.08 High High
Gastroenteritis 1 85.64 High High
Sepsis 4 76.84 Quite High
INFLAMMATION 7 75.00 Quite High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High
Bacterial Infection 1 75.00 Quite High
Pressure Volume 2 Under Development 1 69.76 Quite High
Death 1 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.
LPS Positive_regulation (induced) of Gene_expression (production) of TNFalpha associated with paracetamol
1) Confidence 0.26 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.19 Pain Relevance 1.26
Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo.
LPS Neg (not) Positive_regulation (induced) of Gene_expression (production) of TNF-alpha
2) Confidence 0.19 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.86 Pain Relevance 0.66
SP greatly enhanced the LPS-induced macrophage TNF alpha production from stressed animals; in contrast, it produced relatively little effect on macrophages from control animals.
LPS Positive_regulation (induced) of Gene_expression (production) of TNF alpha in macrophages
3) Confidence 0.16 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8597423 Disease Relevance 0.95 Pain Relevance 0.45

General Comments

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