INT61734

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1995
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 13.05
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (HPSE) extracellular region (HPSE) cell adhesion (HPSE)
nucleus (HPSE) carbohydrate metabolic process (HPSE) lysosome (HPSE)
Anatomy Link Frequency
pituitary 2
gonadal 1
HPSE (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 10 99.84 Very High Very High Very High
depression 140 99.60 Very High Very High Very High
rheumatoid arthritis 154 98.52 Very High Very High Very High
Fibrositis 154 98.52 Very High Very High Very High
corticosteroid 14 97.68 Very High Very High Very High
tolerance 13 96.96 Very High Very High Very High
cytokine 42 96.16 Very High Very High Very High
Neurotransmitter 8 94.24 High High
Inflammation 41 91.16 High High
Lasting pain 4 85.40 High High
Disease Link Frequency Relevance Heat
Injury 29 100.00 Very High Very High Very High
Depression 232 99.60 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

9 99.50 Very High Very High Very High
Congenital Anomalies 23 99.02 Very High Very High Very High
Stress 357 98.96 Very High Very High Very High
Disease 63 98.72 Very High Very High Very High
Rheumatoid Arthritis 154 98.52 Very High Very High Very High
Fibromyalgia 154 98.52 Very High Very High Very High
Chronic Fatigue Syndrome 140 97.84 Very High Very High Very High
Cognitive Disorder 37 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that hypercortisolism is not the only form of HPA dysregulation in major depression.
Regulation (dysregulation) of HPA associated with depression
1) Confidence 0.60 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8597444 Disease Relevance 1.70 Pain Relevance 0.47
Thus, intrauterine-induced alteration of HPA axis regulation seems to persist into the postnatal period and represents a prerequisite for the hypothesis of HPA axis involvement in the fetal origin of adult diseases.
Regulation (regulation) of HPA associated with disease
2) Confidence 0.60 Published 2009 Journal Pediatr. Res. Section Abstract Doc Link 18948839 Disease Relevance 0.86 Pain Relevance 0.07
Thus, the ppDyn mRNA and HPA responses to cocaine in guinea pigs are similar to those observed in rats.
Regulation (responses) of HPA associated with cocaine
3) Confidence 0.26 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11427339 Disease Relevance 0.06 Pain Relevance 0.47
CONCLUSIONS: Chronic drinking, gender, and age influence the activity of the HPA-axis and pituitary beta-END, which in turn may influence drinking behavior.


Regulation (influence) of HPA in pituitary
4) Confidence 0.26 Published 2003 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 12658106 Disease Relevance 0.05 Pain Relevance 0
Such a study would help determine whether Pb affects HPA reactivity or HPA feedback sensitivity—an important distinction that would help direct future studies of Pb-induced HPA dysregulation.
Spec (whether) Regulation (dysregulation) of HPA
5) Confidence 0.24 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2235205 Disease Relevance 0.07 Pain Relevance 0.05
Excessive opioid inhibition of the HPA is thus an unlikely explanation for the HPA dysregulation in this disorder.


Regulation (dysregulation) of HPA
6) Confidence 0.23 Published 1998 Journal Psychol Med Section Body Doc Link 9572086 Disease Relevance 0.15 Pain Relevance 0
It is important to detect the role of HPA and HPG axes in the pathogenesis of fibromyalgia and CFS, to define new treatment strategies for both.
Regulation (role) of HPA associated with chronic fatigue syndrome and fibrositis
7) Confidence 0.22 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.61 Pain Relevance 0.39
For example, if Pb exposure affects HPA feedback sensitivity, Pb interference with type I and II corticosteroid receptors or impaired glucocorticoid inhibition of adrenocorticotropic hormone secretion might be a target for future study.
Regulation (affects) of HPA associated with corticosteroid
8) Confidence 0.18 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2235205 Disease Relevance 0.07 Pain Relevance 0.05
Neuroendocrine abnormalities have been observed in both disorders, including dysregulation of the hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes [4-6].
Regulation (dysregulation) of HPA in gonadal associated with congenital anomalies
9) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 2.00 Pain Relevance 0.38
However, Pb-induced dysregulation of the HPA axis has not yet been studied in humans.


Regulation (dysregulation) of HPA
10) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2235205 Disease Relevance 0.26 Pain Relevance 0
In some studies, HPA dysregulation and consequent hypercortisolemia have shown a significant negative association with cognitive functioning (McEwen 1998; Sapolsky 1996).
Regulation (dysregulation) of HPA associated with cognitive disorder
11) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2235205 Disease Relevance 1.02 Pain Relevance 0
Several studies have directly illustrated the effect of childhood trauma on HPA axis function.
Regulation (effect) of HPA associated with injury
12) Confidence 0.07 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.97 Pain Relevance 0.03
We did not examine the effects of age, gender or genetics on HPA axis function, and it is likely these may explain some of the variation in results.
Neg (not) Spec (examine) Regulation (effects) of HPA
13) Confidence 0.07 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.52 Pain Relevance 0
CONCLUSIONS: The route of administration may modulate ethanol's effects on HPA activity.
Regulation (effects) of HPA
14) Confidence 0.06 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15100607 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The route of administration may modulate ethanol's effects on HPA activity.
Regulation (modulate) of HPA
15) Confidence 0.06 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15100607 Disease Relevance 0 Pain Relevance 0
The hypothalamic-pituitary-adrenal (HPA) axis is also affected to varying degrees in patients with RA, independent of the use of exogenous glucocorticoids.
Regulation (affected) of HPA in pituitary associated with rheumatoid arthritis
16) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 1.39 Pain Relevance 0.58
Glucocorticoids exert negative feedback control on the HPA axis by suppressing hypothalamic CRH production and ACTH secretion.
Regulation (control) of HPA
17) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.91 Pain Relevance 0.63
Hyperesponsivity of the HPA axis under stressful environmental conditions has been associated with depression in several studies [e.g., [50-53]].
Regulation (Hyperesponsivity) of HPA associated with depression
18) Confidence 0.03 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3009949 Disease Relevance 0.98 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox