INT6174

Context Info Confidence 0.61 First Reported 1980 Last Reported 2010 Negated 9 Speculated 5 Reported most in Abstract Documents 49 Total Number 54 Disease Relevance 9.75 Pain Relevance 27.69

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)

Anatomy Link Frequency plasma 18 brain 8 pituitary 6 vas deferens 6 CSF 4 POMC (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 249 100.00 Enkephalin 169 100.00 Pain 47 100.00 Opioid 38 100.00 anesthesia 16 100.00 opiate 12 100.00 cytokine 11 100.00 agonist 8 100.00 corticosteroid 7 100.00 substance P 6 100.00

Disease Link Frequency Relevance Heat Pain 56 100.00 Syndrome 34 100.00 Cyst 6 100.00 Parkinson's Disease 2 99.84 Gastrointestinal Neoplasms 1 99.68 Bacterial Infection 1 99.64 Stress 103 99.50 Dementia 2 99.32 Obesity 13 98.76 Akathisia 1 98.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of this study was to determine, whether ultraviolet irradiation affects the expression of both alpha-melanocyte-stimulating hormone and the melanocortin-1 receptor in human epidermis in vivo.

Spec (whether) Regulation (affects) of Gene_expression (expression) of alpha-melanocyte-stimulating hormone in epidermis associated with melanocortin 1 receptor

1) Confidence 0.61 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15009732 Disease Relevance 0.48 Pain Relevance 0.31

These observations provide evidence that sex steroids regulate expression of the POMC gene in the primate brain.

Regulation (regulate) of Gene_expression (expression) of POMC gene in brain

2) Confidence 0.60 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004607 Disease Relevance 0 Pain Relevance 0

This study demonstrates that aberrant regulation of POMC synthesis and peptide processing can be seen in tumors which synthesize a POMC RNA identical in size to that made in the pituitary gland.

Regulation (regulation) of Gene_expression (synthesis) of POMC in pituitary gland associated with cancer

3) Confidence 0.60 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2456259 Disease Relevance 0.80 Pain Relevance 0.17

Testosterone regulates pro-opiomelanocortin gene expression in the primate brain.

Regulation (regulates) of Gene_expression (expression) of pro-opiomelanocortin gene in brain

4) Confidence 0.52 Published 1991 Journal Endocrinology Section Title Doc Link 2004607 Disease Relevance 0 Pain Relevance 0.10

Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha.

Regulation (Modulation) of in melanocytes Gene_expression (expression) of melanocyte-stimulating hormone in melanocyte associated with necrosis, cancer and cytokine

5) Confidence 0.47 Published 1998 Journal Br. J. Dermatol. Section Title Doc Link 9767234 Disease Relevance 0.35 Pain Relevance 0.17

Basal levels of beta-endorphin and met-enkephalin in the lumbar cerebrospinal fluid (CSF) of these patients were not different from those in pain-free control subjects.

Neg (not) Regulation (different) of Gene_expression (levels) of beta-endorphin in CSF associated with pain and enkephalin

6) Confidence 0.45 Published 1980 Journal Lancet Section Abstract Doc Link 6107591 Disease Relevance 0.37 Pain Relevance 1.03

Continuous subcutaneous octreotide in gastrointestinal cancer patients: pain control and beta-endorphin levels.

Regulation (control) of Gene_expression (levels) of beta-endorphin associated with pain, analgesic and gastrointestinal neoplasms

7) Confidence 0.45 Published 2000 Journal Anticancer Res. Section Title Doc Link 11268498 Disease Relevance 0.20 Pain Relevance 0.49

We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.

Regulation (regulating) of Gene_expression (levels) of adrenocorticotropic hormone

8) Confidence 0.45 Published 1988 Journal Clin. Sci. Section Abstract Doc Link 2827940 Disease Relevance 0 Pain Relevance 0.24

We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.

Regulation (regulating) of Gene_expression (levels) of beta-endorphin

9) Confidence 0.45 Published 1988 Journal Clin. Sci. Section Abstract Doc Link 2827940 Disease Relevance 0 Pain Relevance 0.24

This study was designed to investigate the effect of dermorphin (D), a new synthetic potent opiate-like peptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), on PRA, plasma aldosterone (PA), plasma cortisol (PC), and plasma ACTH levels in normal men.

Spec (investigate) Regulation (effect) of Gene_expression (levels) of ACTH in plasma associated with opiate

10) Confidence 0.44 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313731 Disease Relevance 0 Pain Relevance 0.38

The effects of a single bolus dose of etomidate 0.3 mg kg-1 or thiopentone 5 mg kg-1, on the synthesis of corticosteroid hormones and adrenocorticotrophic hormone (ACTH), were compared for 24 h in 12 patients, undergoing minor surgery under general anaesthesia.

Regulation (effects) of Gene_expression (synthesis) of ACTH associated with corticosteroid

11) Confidence 0.44 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 2982387 Disease Relevance 0 Pain Relevance 0.18

Tissue concentrations of immunoreactive lipotrophin, beta-endorphin, and met-enkephalin were determined in 10 phaeochromocytomas, 3 of which were responsible for the ectopic ACTH syndrome.

Regulation (responsible) of Gene_expression (syndrome) of ACTH associated with syndrome and enkephalin

12) Confidence 0.44 Published 1982 Journal Acta Endocrinol. Section Abstract Doc Link 6289592 Disease Relevance 0.33 Pain Relevance 0.30

Neither ACTH nor prolactin level in the plasma was related to the dental pain threshold elevation during ischemia.

Neg (Neither) Regulation (related) of Gene_expression (level) of ACTH in plasma associated with pain threshold and ischemia

13) Confidence 0.44 Published 1982 Journal Brain Res. Section Abstract Doc Link 6293648 Disease Relevance 1.09 Pain Relevance 1.17

Uncoupled ACTH and BE patterns may result from modified control of pro-opiomelanocortin (POMC) expression during pregnancy or unique proteolytic processing of POMC, and may alter pain tolerance during delivery.

Regulation (control) of Gene_expression (expression) of POMC associated with pain and tolerance

14) Confidence 0.44 Published 1995 Journal Peptides Section Abstract Doc Link 7784247 Disease Relevance 0.10 Pain Relevance 0.57

The current study sought to define the effects of altered adiposity on the expression of genes for neuropeptide Y (NPY), POMC, enkephalin (ENK), and melanin-concentrating hormone (MCH).

Regulation (effects) of Gene_expression (expression) of POMC associated with neuropeptide and enkephalin

15) Confidence 0.44 Published 2000 Journal Endocrinology Section Abstract Doc Link 10746657 Disease Relevance 0.29 Pain Relevance 0.32

It is probable that bacterial infection affects the progression of POMC symptoms.

Regulation (affects) of Gene_expression (progression) of POMC associated with cyst and bacterial infection

16) Confidence 0.44 Published 2005 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 16238591 Disease Relevance 0.73 Pain Relevance 0.10

In the past year, the expression of full-length POMC mRNA has been reported and this solved one of the paradoxes with respect to POMC production, processing, and secretion.

Regulation (respect) of Gene_expression (production) of POMC

17) Confidence 0.44 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10816649 Disease Relevance 0.08 Pain Relevance 0.28

The present studies were undertaken to characterize further the influence of synthetic human beta-endorphin (0.5 mg/h) on insulin and glucagon responses to intravenous glucose in humans.

Regulation (influence) of Gene_expression (synthetic) of beta-endorphin

18) Confidence 0.43 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.08 Pain Relevance 0

Basal levels of beta-endorphin and met-enkephalin in the lumbar cerebrospinal fluid (CSF) of these patients were not different from those in pain-free control subjects.

Neg (not) Regulation (different) of Gene_expression (levels) of met-enkephalin in CSF associated with pain and enkephalin

19) Confidence 0.40 Published 1980 Journal Lancet Section Abstract Doc Link 6107591 Disease Relevance 0.37 Pain Relevance 1.03

It was studied whether traditional Chinese (manual) acupuncture affected CSF levels of met-enkephalin or beta-endorphin in these patients, and to what extent this treatment would be beneficial for the headache.

Spec (whether) Regulation (affected) of Gene_expression (levels) of beta-endorphin associated with headache, enkephalin and acupuncture

20) Confidence 0.39 Published 1989 Journal Headache Section Abstract Doc Link 2529227 Disease Relevance 0.26 Pain Relevance 0.92

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