INT61742

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Context Info
Confidence 0.21
First Reported 1996
Last Reported 2002
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (CHST5) Golgi apparatus (CHST5) carbohydrate metabolic process (CHST5)
Anatomy Link Frequency
pancreas 2
liver 1
acinar cells 1
CHST5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 17 50.00 Quite Low
Inflammation 1 35.92 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 25 91.60 High High
Gastrointestinal Disease 1 75.00 Quite High
Pancreatic Cancer 8 50.00 Quite Low
Inflammatory Bowel Disease 1 35.92 Quite Low
Cancer 1 31.60 Quite Low
Enteropathy 1 29.52 Quite Low
Liver Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Class Alpha glutathione S-transferases (GST-Alpha) are found in high concentrations in human liver.
Gene_expression (found) of GST-Alpha in liver
1) Confidence 0.21 Published 1996 Journal Clin. Chem. Section Abstract Doc Link 8598105 Disease Relevance 0.07 Pain Relevance 0
However, in four of 18 primary chronic pancreatitis specimens, more islet cells (approximately 25%) expressed GST-alpha than in the normal pancreas and secondary chronic pancreatitis (both approximately 10%).
Gene_expression (expressed) of GST-alpha in pancreas
2) Confidence 0.04 Published 2002 Journal Pancreas Section Body Doc Link 11893938 Disease Relevance 0.16 Pain Relevance 0
AIMS AND METHODOLOGY: To examine whether the increased number of islet cells expressing GST-pi and the absence in the acinar cells are compensated for by other GST isozymes, we investigated the expression of GST-alpha and GST-mu in the same specimens.
Spec (investigated) Gene_expression (expression) of GST-alpha in acinar cells
3) Confidence 0.04 Published 2002 Journal Pancreas Section Body Doc Link 11893938 Disease Relevance 0.18 Pain Relevance 0
RESULTS: Unlike the distribution of GST-pi, the distribution of GST-alpha and GST-mu in islets did not show marked differences between the three groups.
Gene_expression (distribution) of GST-alpha
4) Confidence 0.03 Published 2002 Journal Pancreas Section Body Doc Link 11893938 Disease Relevance 0.17 Pain Relevance 0
Contrary to the expression of GST-pi, no statistically significant differences were found in the distribution of GST-alpha and GST-mu in the normal pancreas, chronic pancreatitis, and secondary chronic pancreatitis.
Gene_expression (distribution) of GST-alpha in pancreas
5) Confidence 0.03 Published 2002 Journal Pancreas Section Body Doc Link 11893938 Disease Relevance 0.12 Pain Relevance 0

General Comments

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