INT61755

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Context Info
Confidence 0.58
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 6.32
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (A1cf) mRNA processing (A1cf) endoplasmic reticulum (A1cf)
nucleus (A1cf) intracellular (A1cf) cytoplasm (A1cf)
Anatomy Link Frequency
colon 2
A1cf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 1 97.20 Very High Very High Very High
diclofenac 1 95.30 Very High Very High Very High
anesthesia 4 93.12 High High
COX-2 inhibitor 5 85.28 High High
alcohol 4 83.68 Quite High
Antihistamine 1 81.52 Quite High
cINOD 13 79.12 Quite High
COX2 4 75.44 Quite High
Inflammation 21 73.88 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 151 100.00 Very High Very High Very High
Decapitation 4 92.00 High High
Body Weight 21 90.88 High High
INFLAMMATION 30 78.72 Quite High
Colon Cancer 95 75.28 Quite High
Cancer 57 66.36 Quite High
Familial Adenomatous Polyposis 24 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 12 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the initiation phase carboxyl amidoimidazole, p-chlorphenylacetate, chlorpheniramine maleate, D609, diclofenac, etoperidone, eicosatetraynoic acid, farnesol, ferulic acid, lycopene, meclizine, methionine, phenylhexylisothiocyanate, phenylbutyrate, piroxicam, 9-cis-retinoic acid, S-allylcysteine, taurine, tetracycline and verapamil were strong inhibitors of ACF.
Negative_regulation (inhibitors) of ACF associated with aberrant crypt foci and diclofenac
1) Confidence 0.58 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10837003 Disease Relevance 0.58 Pain Relevance 0.22
CONCLUSIONS: Cyclooxygenase-2 inhibitors are potentially ideal chemopreventive agents as they inhibit ACF and are not gastrotoxic.


Negative_regulation (inhibit) of ACF
2) Confidence 0.39 Published 2000 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 11197048 Disease Relevance 0.06 Pain Relevance 0
At this time, nimesulide at doses of 50, 100 and 200 ppm had reduced the numbers of azoxymethane-induced ACF to 75%, 71% and 65% respectively compared to the control.
Negative_regulation (reduced) of ACF associated with aberrant crypt foci
3) Confidence 0.35 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8601574 Disease Relevance 0.77 Pain Relevance 0.21
RESULTS: All test agents reduced the number of ACF.
Negative_regulation (reduced) of ACF
4) Confidence 0.34 Published 2000 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 11197048 Disease Relevance 0.07 Pain Relevance 0
However, the association of FOS and celecoxib resulted in a 61% reduction in the number of ACF (P < 0.01).
Negative_regulation (reduction) of ACF associated with aberrant crypt foci
5) Confidence 0.31 Published 2003 Journal Reprod. Nutr. Dev. Section Abstract Doc Link 14971826 Disease Relevance 0.77 Pain Relevance 0.10
However, the association of FOS and celecoxib resulted in a 61% reduction in the number of ACF (P < 0.01).
Negative_regulation (number) of ACF associated with aberrant crypt foci
6) Confidence 0.31 Published 2003 Journal Reprod. Nutr. Dev. Section Abstract Doc Link 14971826 Disease Relevance 0.77 Pain Relevance 0.10
Three weeks later, the rats were injected twice with azoxymethane and the number of ACF was determined 15 weeks later.
Negative_regulation (number) of ACF associated with aberrant crypt foci
7) Confidence 0.31 Published 2003 Journal Reprod. Nutr. Dev. Section Abstract Doc Link 14971826 Disease Relevance 0.79 Pain Relevance 0.11
Reduction in the total number of ACF and AC, and multicrypt of ACF with increase in the percentage of GBR was observed but yet insignificant.
Negative_regulation (number) of ACF associated with aberrant crypt foci
8) Confidence 0.09 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.68 Pain Relevance 0
Reduction in the total number of ACF and AC, and multicrypt of ACF with increase in the percentage of GBR was observed but yet insignificant.
Negative_regulation (Reduction) of ACF associated with aberrant crypt foci
9) Confidence 0.09 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.68 Pain Relevance 0
It indicates that there was a significant reduction (p < 0.05) in the total number of ACF and AC, and multicrypt of ACF per colon in all the groups treated with GBR (G2, G3 and G4) compared to the control group (G1).
Negative_regulation (number) of ACF in colon associated with aberrant crypt foci
10) Confidence 0.09 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.68 Pain Relevance 0
The total number of ACF and AC per colon was recorded.


Negative_regulation (number) of ACF in colon associated with aberrant crypt foci
11) Confidence 0.09 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.46 Pain Relevance 0.13

General Comments

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