INT61756

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Context Info
Confidence 0.57
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.94
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (A1cf) mRNA processing (A1cf) endoplasmic reticulum (A1cf)
nucleus (A1cf) intracellular (A1cf) cytoplasm (A1cf)
Anatomy Link Frequency
colon 2
Blood 1
striatum 1
A1cf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 7 98.44 Very High Very High Very High
anesthesia 4 96.72 Very High Very High Very High
Inflammation 9 92.12 High High
COX2 12 89.76 High High
positron emission tomography 1 88.28 High High
Dopamine 2 84.76 Quite High
cINOD 8 80.36 Quite High
cocaine 1 77.08 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aberrant Crypt Foci 53 100.00 Very High Very High Very High
Fistula 21 100.00 Very High Very High Very High
Colon Cancer 28 97.08 Very High Very High Very High
Apoptosis 31 96.72 Very High Very High Very High
Overdose 1 93.76 High High
INFLAMMATION 14 92.12 High High
Body Weight 9 88.24 High High
Cancer 20 84.60 Quite High
Malignant Neoplastic Disease 3 68.36 Quite High
Colorectal Cancer 1 25.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At this time, nimesulide at doses of 50, 100 and 200 ppm had reduced the numbers of azoxymethane-induced ACF to 75%, 71% and 65% respectively compared to the control.
Positive_regulation (induced) of ACF associated with aberrant crypt foci
1) Confidence 0.57 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8601574 Disease Relevance 0.76 Pain Relevance 0.21
To assess this possibility the inhibitory effects of nimesulide on the formation of ACF induced by azoxymethane in rat colon were investigated, and compared with those of piroxicam and sulindac.
Positive_regulation (induced) of ACF in colon associated with aberrant crypt foci
2) Confidence 0.44 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8601574 Disease Relevance 0.80 Pain Relevance 0.21
The number of azoxymethane-induced ACF per colon in the group given 200 ppm nimesulide was almost the same as in those given 200 piroxicam, and lower than that in the group given 200 ppm sulindac.
Positive_regulation (induced) of ACF in colon associated with aberrant crypt foci
3) Confidence 0.38 Published 1996 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 8601574 Disease Relevance 0.74 Pain Relevance 0.20
METHODS: Aberrant crypt foci (ACF) were induced in Sprague-Dawley rats by using 1,2-dimethylhydrazine (DMH).
Positive_regulation (induced) of ACF
4) Confidence 0.37 Published 2000 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 11197048 Disease Relevance 0.10 Pain Relevance 0
During weeks 2 and 3 rats were injected with 10 mg/kg azoxymethane to induce ACF.
Positive_regulation (induce) of ACF associated with aberrant crypt foci
5) Confidence 0.27 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11748382 Disease Relevance 1.09 Pain Relevance 0.09
Blood flow increased 5-fold immediately after ACF (P<0.05).
Positive_regulation (increased) of ACF in Blood associated with fistula
6) Confidence 0.17 Published 2002 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC119850 Disease Relevance 0.74 Pain Relevance 0
The administration of 2.5 g/kg, 5 g/kg and 10 g/kg of GBR (weight of GBR (g)/weight of rat (kg)) significantly reduced the total number of ACF, AC, and multicrypt of ACF, and the expression of ?
Positive_regulation (multicrypt) of ACF associated with aberrant crypt foci
7) Confidence 0.10 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.71 Pain Relevance 0
After intravenous injection, [(11)C]beta-CFT and [(11)C]beta-CIT-FE were predominantly accumulated in the striatum in both conscious and ketamine-anesthetized states.
Positive_regulation (accumulated) of beta-CFT in striatum associated with ketamine
8) Confidence 0.02 Published 2001 Journal Synapse Section Abstract Doc Link 11746726 Disease Relevance 0 Pain Relevance 0.57

General Comments

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