INT6176

Context Info Confidence 0.67 First Reported 1987 Last Reported 2010 Negated 0 Speculated 7 Reported most in Abstract Documents 117 Total Number 134 Disease Relevance 28.23 Pain Relevance 66.17

plasma membrane (Htr1a) signal transducer activity (Htr1a)

Anatomy Link Frequency neurons 7 5-HT neurons 6 spinal 5 hippocampus 4 medulla 3 Htr1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 406 100.00 fluoxetine 282 100.00 Serotonin 273 100.00 antidepressant 214 100.00 Pain 70 100.00 Raphe 47 100.00 Central grey 29 100.00 nociceptor 8 100.00 Calcium channel 10 99.92 Dopamine 38 99.86

Disease Link Frequency Relevance Heat Urological Neuroanatomy 220 100.00 Bordatella Infection 6 100.00 Nociception 48 99.72 Ganglion Cysts 23 99.50 Cv General 4 Under Development 4 99.40 Heart Rate Under Development 446 99.32 Amnesia 3 99.28 Stress 14 99.24 Appetite Loss 7 99.18 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 4 99.06

Sentences Mentioned In

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Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses.

Positive_regulation (activation) of 5-HT1A in brain associated with sumatriptan

1) Confidence 0.67 Published 1999 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 10101238 Disease Relevance 0 Pain Relevance 0.65

To assess this hypothesis, we tested the effects of either (i). a near-total 5,7-dihydroxytryptamine-induced lesion (90% depletion) or (ii). an acute serotonin (5-HT) inhibition induced by the specific stimulation of 5-HT1A autoreceptors (8-OHDPAT 5-100 microg/kg), on naloxone-induced conditioned place aversion in morphine-dependent rats.

Positive_regulation (stimulation) of 5-HT1A associated with narcan, serotonin and morphine

2) Confidence 0.67 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12589380 Disease Relevance 0.09 Pain Relevance 1.12

The increases in extracellular serotonin (5-hydroxytryptamine; 5-HT) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-HT1A autoreceptors by the excess 5-HT induced by these agents in the midbrain raphe.

Positive_regulation (activation) of 5-HT1A in forebrain associated with midbrain, raphe and serotonin

3) Confidence 0.67 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8971795 Disease Relevance 0 Pain Relevance 0.58

Also, 5-HT1A receptor activation seemed to cooperate with nociceptive stimulation in, paradoxically, inducing an antiallodynic effect.

Positive_regulation (activation) of 5-HT1A associated with nociception and antiallodynic

4) Confidence 0.67 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730352 Disease Relevance 0.77 Pain Relevance 1.32

These results indicate that a large portion of the measurable 5-HT output in the cerebellum is of neuronal origin, is dependent on impulse flow, and is sensitive to 5-HT1A autoreceptor activation.

Positive_regulation (activation) of 5-HT1A in cerebellum

5) Confidence 0.67 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8764587 Disease Relevance 0 Pain Relevance 0.23

That is, in contrast with morphine, the antiallodynic effect induced by 5-HT1A receptor activation does not decay, but, if anything, grows with chronicity.

Positive_regulation (activation) of 5-HT1A associated with antiallodynic and morphine

6) Confidence 0.67 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730352 Disease Relevance 0.70 Pain Relevance 1.38

These results demonstrate that, under the present experimental conditions, activation of central 5-HT1A, 5-HT1B, and 5-HT2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm.

Positive_regulation (activation) of 5-HT1A

7) Confidence 0.67 Published 1998 Journal Alcohol Section Abstract Doc Link 9744857 Disease Relevance 0.07 Pain Relevance 0.55

The present results strongly suggest that previous activation of 5-HT1A receptors or antagonism of 5-HT2A receptors protects against heatstroke by reducing circulatory shock and cerebral ischemia, whereas prior antagonism of 5-HT1A receptors or activation of 5-HT2A receptors exacerbates heatstroke.

Positive_regulation (activation) of 5-HT1A associated with heat stroke, cv general 4 under development, ischemia and shock

8) Confidence 0.67 Published 2005 Journal Shock Section Abstract Doc Link 16205318 Disease Relevance 1.48 Pain Relevance 0.32

The results suggest that stimulation of 5-HT1A receptors in the dorsal hippocampus impairs rats' performance in a passive avoidance task by interfering with memory processes or by attenuating the emotional impact of the shock through an anxiolytic action.

Positive_regulation (stimulation) of 5-HT1A in hippocampus associated with anxiety disorder, shock and hippocampus

9) Confidence 0.67 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8097721 Disease Relevance 0.53 Pain Relevance 0.38

Effects of fluoxetine and buspirone on the panicolytic-like response induced by the activation of 5-HT1A and 5-HT2A receptors in the rat dorsal periaqueductal gray.

Positive_regulation (activation) of 5-HT1A in dorsal associated with central grey and fluoxetine

10) Confidence 0.67 Published 2006 Journal Psychopharmacology (Berl.) Section Title Doc Link 16258751 Disease Relevance 0.38 Pain Relevance 0.33

These results demonstrate that activation of 5-HT1A and 5-HT2 receptors can excite or inhibit populations of NTS neurones.

Positive_regulation (activation) of 5-HT1A

11) Confidence 0.67 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225274 Disease Relevance 0 Pain Relevance 0.16

It is concluded that 5-HT via activation of 5-HT1A, 5-HT2A, 5-HT2C and possibly also 5-HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe, which results in increased ACTH secretion.

Spec (possibly) Positive_regulation (activation) of 5-HT1A in lobe

12) Confidence 0.67 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.31

Results are consistent with involvement of the dopaminergic and 5-HT systems, in particular activation of 5-HT1A and 5-HT1B receptor subtypes, in mediation of the conditioned or secondary reinforcing properties of ethanol.

Positive_regulation (activation) of 5-HT1A

13) Confidence 0.67 Published 2000 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 11198050 Disease Relevance 0.06 Pain Relevance 0.46

Because hypothalamic Gz proteins mediate the ACTH and oxytocin responses to 5-HT1A receptor activation, we also determined the effect of fluoxetine on the levels of Gz proteins in the hypothalamus.

Positive_regulation (activation) of 5-HT1A in hypothalamus associated with fluoxetine

14) Confidence 0.67 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9862759 Disease Relevance 0 Pain Relevance 0.64

Thus, fluoxetine increased [5-HT(ext)] in serotonergic nerve terminal areas and consequently, induced hypophagia, both effects being limited by indirect activation of somatodendritic 5-HT1A autoreceptors.

Positive_regulation (activation) of 5-HT1A in nerve associated with appetite loss and fluoxetine

15) Confidence 0.67 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9797034 Disease Relevance 0.10 Pain Relevance 0.50

These modifications of 5-HT neurons lead to an increased tonic activation of postsynaptic 5-HT1A receptors.

Positive_regulation (activation) of 5-HT1A in 5-HT neurons

16) Confidence 0.67 Published 1998 Journal J Affect Disord Section Abstract Doc Link 10333981 Disease Relevance 0 Pain Relevance 0.46

Systemic administration of agents that (1) increase synaptic levels of serotonin (5-HT) or dopamine (DA); (2) activate 5-HT1A, 5-HT2, D2, D3, or GABA(A) receptors; or (3) block opioid and 5-HT3 receptors decrease ethanol intake in most animal models.

Positive_regulation (activate) of 5-HT1A associated with gaba, dopamine, opioid and serotonin

17) Confidence 0.67 Published 1998 Journal Crit Rev Neurobiol Section Abstract Doc Link 10348615 Disease Relevance 0.36 Pain Relevance 1.02

It is hypothesized that the delayed maximal increase in extracellular 5-HT contents after fluoxetine treatment, due to negative feedback regulations induced by the activation of 5-HT1A and 5-HT1B autoreceptors, is not the primary cause for the delayed normalization of corticosteroid receptor numbers that regulates the HPA axis functioning.

Positive_regulation (activation) of 5-HT1A associated with corticosteroid and fluoxetine

18) Confidence 0.67 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10929085 Disease Relevance 0 Pain Relevance 0.67

In conclusion, in the basolateral amygdala nuclei, tandospirone activated presynaptic 5-HT1A receptors on the GABAergic nerve terminals projecting to ovoid-shaped neurons and inhibited synaptic GABA transmission via G-proteins.

Positive_regulation (activated) of 5-HT1A in neurons associated with gaba, gabaergic and amygdala

19) Confidence 0.67 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068021 Disease Relevance 0.09 Pain Relevance 0.38

Activation of 5-HT1A receptors by 8-OH-DPAT (1 microM) evoked no direct postsynaptic effects in enzyme-treated isolated basolateral amygdala neurons, suggesting that tandospirone acts at presynaptic 5-HT1A receptors.

Positive_regulation (Activation) of 5-HT1A in neurons associated with amygdala

20) Confidence 0.67 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068021 Disease Relevance 0.08 Pain Relevance 0.50

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