INT6179

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 9.24
Pain Relevance 24.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
brain 2
PC-12 1
cerebrum 1
spinal cord 1
bone marrow 1
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 209 100.00 Very High Very High Very High
Opioid 85 100.00 Very High Very High Very High
Kappa opioid receptor 83 100.00 Very High Very High Very High
MU agonist 6 100.00 Very High Very High Very High
Cannabinoid 5 100.00 Very High Very High Very High
agonist 38 99.96 Very High Very High Very High
alcohol 252 99.80 Very High Very High Very High
Antinociceptive 18 99.80 Very High Very High Very High
antinociception 20 99.58 Very High Very High Very High
Pain 22 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 14 100.00 Very High Very High Very High
Lewis Lung Carcinoma 8 99.84 Very High Very High Very High
Alcohol Addiction 245 99.80 Very High Very High Very High
Pain 11 99.16 Very High Very High Very High
Thymoma 6 99.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 98.52 Very High Very High Very High
Epilepsy 5 98.44 Very High Very High Very High
Urological Neuroanatomy 3 97.08 Very High Very High Very High
Stress 10 96.36 Very High Very High Very High
Pheochromocytoma 1 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that this aversive effect might partly be due to kappa-opioid receptor interaction.
kappa-opioid receptor Spec (might) Binding (interaction) of associated with kappa opioid receptor
1) Confidence 0.48 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882032 Disease Relevance 0.08 Pain Relevance 0.71
Variations in other opioid receptor genes were not associated with alcohol dependence in the same large, family-based sample in which the association with OPRK1 was reported (17).
OPRK1 Binding (association) of associated with addiction, opioid receptor and alcohol
2) Confidence 0.48 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.77 Pain Relevance 0.94
An earlier study of three coding SNPs in Taiwanese Han subjects found no association between OPRK1 and alcohol dependence (19).
OPRK1 Neg (no) Binding (association) of associated with addiction and alcohol
3) Confidence 0.48 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.73 Pain Relevance 1.09
The binding of the kappa-opioid receptor agonist [3H](-)-bremazocine to R1.1 cell membranes was unchanged following treatment with the disulfide bond-reducing reagent dithiothreitol at concentrations up to 130 mM.
kappa-opioid receptor Binding (binding) of associated with agonist and kappa opioid receptor
4) Confidence 0.48 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8206123 Disease Relevance 0.17 Pain Relevance 0.28
It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells.
KOR Binding (binding) of in stem cells associated with kappa opioid receptor
5) Confidence 0.47 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.06 Pain Relevance 0.44
Therefore, we conclude that this indel is a functional variation that explains at least part of the association of OPRK1 with alcoholism.
OPRK1 Binding (association) of associated with alcohol addiction
6) Confidence 0.42 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.48 Pain Relevance 0.58
On the other hand, the correlation between binding affinity to kappa opioid receptor and antinociceptive activity was statistically significant.
kappa opioid receptor Binding (affinity) of associated with kappa opioid receptor and antinociceptive
7) Confidence 0.38 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1323679 Disease Relevance 0 Pain Relevance 0.56
We previously reported that SNPs in intron 2 of OPRK1, the gene encoding the KOR, were associated with alcohol dependence; three synonymous SNPs were not associated (17).
OPRK1 Binding (associated) of associated with addiction, opioid receptor and alcohol
8) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.22 Pain Relevance 0.34
OBJECTIVES: To characterize kappa opioid receptor (KOR) distribution in the neonatal mouse brain and test whether neonatal exposure to morphine, stress, or both, change KOR signaling.
KOR Binding (characterize) of in brain
9) Confidence 0.37 Published 2009 Journal Neonatology Section Body Doc Link 19478529 Disease Relevance 0.10 Pain Relevance 0
OBJECTIVES: To characterize kappa opioid receptor (KOR) distribution in the neonatal mouse brain and test whether neonatal exposure to morphine, stress, or both, change KOR signaling.
kappa opioid receptor Binding (characterize) of in brain
10) Confidence 0.37 Published 2009 Journal Neonatology Section Body Doc Link 19478529 Disease Relevance 0.10 Pain Relevance 0
The results indicate that a sulfhydryl group is present at or near the binding site on the kappa-opioid receptor expressed by the R1.1 thymoma cell line.
kappa-opioid receptor Binding (binding) of associated with thymoma and kappa opioid receptor
11) Confidence 0.37 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8206123 Disease Relevance 0.23 Pain Relevance 0.34
This indel is, therefore, a functional regulatory variation likely to explain at least part of the association of OPRK1 with alcohol dependence.



OPRK1 Binding (association) of associated with addiction and alcohol
12) Confidence 0.36 Published 2008 Journal Human Molecular Genetics Section Abstract Doc Link PMC2405904 Disease Relevance 0.40 Pain Relevance 0.33
The association of OPRK1 with alcoholism was confirmed by a second study, reporting that a haplotype of OPRK1 was associated with alcohol dependence (18), although individual SNPs were not; it should be noted that Zhang et al. (18) did not test any SNPs in intron 2, the region where association had earlier been reported.
OPRK1 Binding (association) of associated with addiction, alcohol addiction and alcohol
13) Confidence 0.36 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.51 Pain Relevance 0.94
In addition, this study indicates that delta 9-THC and the kappa opioid agonists may share a common mechanism of action in the production of antinociception and that a possible interaction exists between i.t. administered cannabinoid compounds and the kappa opioid receptor.
kappa opioid receptor Binding (interaction) of associated with antinociception, mu agonist, cannabinoid and kappa opioid receptor
14) Confidence 0.35 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138952 Disease Relevance 0 Pain Relevance 0.72
These compounds were found to bind with high affinity and selectivity to the kappa-opioid receptor.
kappa-opioid receptor Binding (bind) of associated with kappa opioid receptor
15) Confidence 0.35 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2850924 Disease Relevance 0 Pain Relevance 0.44
These data represent the demonstration of a functional variant in OPRK1 that is associated with alcoholism.


OPRK1 Binding (associated) of associated with alcohol addiction
16) Confidence 0.31 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.63 Pain Relevance 0.67
LPK-26 showed a high affinity to kappa-opioid receptor with the Ki value of 0.64 nM and the low affinities to micro-opioid receptor and delta-opioid receptor with the Ki values of 1170 nM and >10,000 nM, respectively.
kappa-opioid receptor Binding (affinity) of associated with kappa opioid receptor and opioid receptor
17) Confidence 0.31 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18353307 Disease Relevance 0.06 Pain Relevance 1.15
Salvinorin A ((2S,4aR,6aR,7R,9S,10aS, 10bR)-2H-naphtho[2,1-c]pyran-7-carboxylic acid, 9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo methyl ester, 1, CAS 83729-01-5) has been shown to bind with high affinity and selectivity to the kappa-opioid receptor (KOR) as an agonist.
kappa-opioid receptor Binding (bind) of associated with agonist and kappa opioid receptor
18) Confidence 0.30 Published 2006 Journal Arzneimittelforschung Section Abstract Doc Link 16724512 Disease Relevance 0 Pain Relevance 0.33
Salvinorin A ((2S,4aR,6aR,7R,9S,10aS, 10bR)-2H-naphtho[2,1-c]pyran-7-carboxylic acid, 9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo methyl ester, 1, CAS 83729-01-5) has been shown to bind with high affinity and selectivity to the kappa-opioid receptor (KOR) as an agonist.
KOR Binding (bind) of associated with agonist and kappa opioid receptor
19) Confidence 0.30 Published 2006 Journal Arzneimittelforschung Section Abstract Doc Link 16724512 Disease Relevance 0 Pain Relevance 0.33
Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene.
Kappa2 opioid receptor subtype Binding (binding) of associated with opioid receptor
20) Confidence 0.29 Published 2010 Journal Front Biosci (Schol Ed) Section Title Doc Link 20036983 Disease Relevance 0.26 Pain Relevance 0.57

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