INT61791

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.36
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SH2B2) signal transduction (SH2B2) plasma membrane (SH2B2)
cytoplasm (SH2B2) signal transducer activity (SH2B2)
Anatomy Link Frequency
neurons 2
SH2B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 31 100.00 Very High Very High Very High
interstitial cystitis 11 99.48 Very High Very High Very High
cva 123 98.16 Very High Very High Very High
qutenza 8 94.36 High High
tetrodotoxin 2 91.28 High High
anesthesia 5 90.08 High High
Pyramidal cell 6 81.20 Quite High
Angina 3 79.68 Quite High
aspirin 32 74.48 Quite High
dorsal root ganglion 1 71.04 Quite High
Disease Link Frequency Relevance Heat
Anti-phospholipid Antibody Syndrome 261 100.00 Very High Very High Very High
Heart Arrhythmia 12 100.00 Very High Very High Very High
Immunization 4 99.72 Very High Very High Very High
Stroke 60 99.70 Very High Very High Very High
Thrombosis Related Under Development 138 99.48 Very High Very High Very High
Interstitial Cystitis 11 99.48 Very High Very High Very High
Cardiovascular Disease 14 99.40 Very High Very High Very High
Thrombosis 97 99.20 Very High Very High Very High
Cv General 3 Under Development 24 98.16 Very High Very High Very High
Accessory Atrioventricular Bundle 7 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two cases of using RF-CA for familial PSVT due to APs are presented, in a brother and sister, supporting a potential genetic role in the developmental failure to lose the atrioventricular connection during fetal life.
Positive_regulation (using) of APs associated with heart arrhythmia
1) Confidence 0.50 Published 1998 Journal Jpn. Circ. J. Section Abstract Doc Link 9890199 Disease Relevance 1.37 Pain Relevance 0.08
Just over half of the arterial segments failed to exhibit spontaneous activity; however, APs could be generated during K+-induced depolarization.
Positive_regulation (generated) of APs associated with action potential
2) Confidence 0.50 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8603497 Disease Relevance 0 Pain Relevance 0.37
K+ depolarization failed to induce APs and contraction in the presence of nifedipine.
Neg (failed) Positive_regulation (induce) of APs associated with action potential
3) Confidence 0.41 Published 1996 Journal Circ. Res. Section Abstract Doc Link 8603497 Disease Relevance 0 Pain Relevance 0.43
The aPLs involvement in thrombosis is well evidenced, e.g., APS was induced after immunization with aCL or ?
Positive_regulation (induced) of APS associated with immunization, anti-phospholipid antibody syndrome and thrombosis related under development
4) Confidence 0.40 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.82 Pain Relevance 0.09
The risk for recurrent stroke appears to be increased in APS patients.
Positive_regulation (increased) of APS associated with stroke and anti-phospholipid antibody syndrome
5) Confidence 0.27 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.47 Pain Relevance 0.15
The excitatory dendritic potentials may propagate though the soma of the neuron to the axon to generate APs.
Positive_regulation (generate) of APs in neuron associated with action potential
6) Confidence 0.09 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2906257 Disease Relevance 0 Pain Relevance 0.09
Such a hybrid approach, where conventional APs (operated using some residual muscular functionality) are enhanced by BCI technology, leads to what we call hybrid BCI (hBCI).
Positive_regulation (enhanced) of APs
7) Confidence 0.05 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2944670 Disease Relevance 0 Pain Relevance 0
The number of APs was increased 4.5 fold in FIC neurons.
Positive_regulation (increased) of APs in neurons associated with interstitial cystitis
8) Confidence 0.05 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15869946 Disease Relevance 1.01 Pain Relevance 1.60
Women with no history of thrombosis or prior fetal losses who are found to have APS during a first pregnancy do not need prophylactic therapy.
Positive_regulation (have) of APS associated with anti-phospholipid antibody syndrome and thrombosis
9) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 1.69 Pain Relevance 0.18

General Comments

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