INT61798

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Context Info
Confidence 0.22
First Reported 1996
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (NDP, POMC) extracellular space (NDP, POMC) signal transduction (NDP, POMC)
extracellular region (NDP, POMC) small molecule metabolic process (POMC) cytoplasm (POMC)
Anatomy Link Frequency
melanocyte 1
NDP (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 7 97.76 Very High Very High Very High
agonist 6 75.00 Quite High
antagonist 3 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of disulfide bonds in human melanocortin 1 receptor (hMC1R) with increasing concentrations of DTT (dithiothreitol) resulted in a decrease in the binding of [125I]-ACTH (adrenocorticotropic hormone, L-isomer) in an uniphasic manner and a decrease in [125I]-NDP-MSH ([Nle(4),D-Phe(7)]-alpha-melanocyte stimulating hormone; D-isomer) binding in a biphasic manner.
NDP-MSH Binding (binding) of ACTH in melanocyte associated with melanocortin 1 receptor
1) Confidence 0.22 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.25
Substitution of Asp184 by alanine completely abolished the binding of radiolabelled NDP-MSH as well as ACTH, even though the mutated receptor could be detected on cell surface using anti MC1R specific polyclonal antiserum.
NDP-MSH Binding (binding) of ACTH associated with melanocortin 1 receptor
2) Confidence 0.18 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.41

General Comments

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