INT61799

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Context Info
Confidence 0.20
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.41

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cell-cell signaling (NDP, POMC) extracellular space (NDP, POMC) signal transduction (NDP, POMC)
extracellular region (NDP, POMC) small molecule metabolic process (POMC) cytoplasm (POMC)
NDP (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 96.80 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substitution of Asp184 by alanine completely abolished the binding of radiolabelled NDP-MSH as well as ACTH, even though the mutated receptor could be detected on cell surface using anti MC1R specific polyclonal antiserum.
Negative_regulation (abolished) of NDP-MSH Binding (binding) of ACTH associated with melanocortin 1 receptor
1) Confidence 0.20 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.41

General Comments

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