INT61800

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Context Info
Confidence 0.24
First Reported 1996
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NDP) signal transduction (NDP) extracellular space (NDP)
extracellular region (NDP) cell-cell signaling (NDP)
NDP (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 12 96.16 Very High Very High Very High
agonist 6 83.44 Quite High
antagonist 3 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substitution of Asp184 by alanine completely abolished the binding of radiolabelled NDP-MSH as well as ACTH, even though the mutated receptor could be detected on cell surface using anti MC1R specific polyclonal antiserum.
Negative_regulation (abolished) of NDP-MSH Binding (binding) of associated with melanocortin 1 receptor
1) Confidence 0.24 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.41
Mutations of Ser6, Glu269 and Thr272 resulted in a considerable loss of affinity for radiolabelled NDP-MSH as well as the ability of alpha-MSH to displace the bound radiolabelled NDP-MSH.
Negative_regulation (loss) of NDP-MSH Binding (bound) of
2) Confidence 0.23 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.41
Single point mutation of four cysteine residues in extracellular loops to glycine (C35G, C267G, C273G, and C275G) resulted in a complete loss of binding for [125I]-NDP-MSH.
Negative_regulation (loss) of NDP-MSH Binding (binding) of
3) Confidence 0.22 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.31

General Comments

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