INT61802

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Context Info
Confidence 0.28
First Reported 1996
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NDP) signal transduction (NDP) extracellular space (NDP)
extracellular region (NDP) cell-cell signaling (NDP)
NDP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 97.44 Very High Very High Very High
melanocortin 1 receptor 19 96.16 Very High Very High Very High
antagonist 6 82.00 Quite High
Pain 12 28.44 Quite Low
opiate 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Piles 3 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Initiation And Maintenance Disorders 2 29.16 Quite Low
Pain 11 28.44 Quite Low
Constipation 9 28.20 Quite Low
Spontaneous Abortion 12 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 8 5.00 Very Low Very Low Very Low
Fever 7 5.00 Very Low Very Low Very Low
Diarrhoea 6 5.00 Very Low Very Low Very Low
Candida Infection 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Anorectal Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant at position C78G (with wild-type binding to alpha-MSH as well as NDP-MSH) generated a cAMP signal in response to alpha-MSH (identical to wild-type hMC1R) but interestingly could not be stimulated by NDP-MSH.
NDP-MSH Binding (binding) of
1) Confidence 0.28 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.33
The mutant receptor DNAs were transiently expressed in COS-1 cells and their ability to bind [N1e4,D-Phe7]-alpha-MSH (NDP-MSH) was evaluated.
NDP-MSH Binding (bind) of
2) Confidence 0.20 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.40
Mutations of Ser6, Glu269 and Thr272 resulted in a considerable loss of affinity for radiolabelled NDP-MSH as well as the ability of alpha-MSH to displace the bound radiolabelled NDP-MSH.
NDP-MSH Binding (bound) of
3) Confidence 0.20 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.40
Substitution of Asp184 by alanine completely abolished the binding of radiolabelled NDP-MSH as well as ACTH, even though the mutated receptor could be detected on cell surface using anti MC1R specific polyclonal antiserum.
NDP-MSH Binding (binding) of associated with melanocortin 1 receptor
4) Confidence 0.19 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8605020 Disease Relevance 0 Pain Relevance 0.41
Single point mutation of four cysteine residues in extracellular loops to glycine (C35G, C267G, C273G, and C275G) resulted in a complete loss of binding for [125I]-NDP-MSH.
NDP-MSH Binding (binding) of
5) Confidence 0.18 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11237737 Disease Relevance 0 Pain Relevance 0.31
Dr William LewisÂ’s The new dispensatory, 1770 (abbreviated to ND), also used here, has the advantage of combining material from the pharmacopoeias of both the Edinburgh and London Colleges of Physicians.5
ND Binding (abbreviated) of
6) Confidence 0.06 Published 2008 Journal Medical History Section Body Doc Link PMC2366387 Disease Relevance 0 Pain Relevance 0

General Comments

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