INT61805

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1995
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.41
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
hypothalamus 1
plasma 1
Caco-2 1
immature T cell 1
Dpp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 6 97.84 Very High Very High Very High
Kappa opioid receptor 15 97.52 Very High Very High Very High
Dynorphin 21 97.32 Very High Very High Very High
antagonist 3 93.00 High High
withdrawal 3 91.96 High High
Morphine 4 91.52 High High
monoamine 2 89.76 High High
cINOD 2 83.12 Quite High
substance P 6 77.36 Quite High
Enkephalin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Body Weight 1 90.08 High High
Hepatotoxicity 2 85.80 High High
INFLAMMATION 2 82.92 Quite High
Stress 1 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we found that the activity of dipeptidyl peptidase IV in liver plasma membrane fractions was lowered after diclofenac treatment of rats.
Positive_regulation (activity) of peptidase IV in plasma associated with diclofenac
1) Confidence 0.44 Published 1995 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8605291 Disease Relevance 0.24 Pain Relevance 0.42
The activities of APB, APM and APN appeared to be highest in rat small intestinal mucosa, while DPP IV activity was much higher in Caco-2 cells than that in the rat intestinal mucosa.
Positive_regulation (higher) of DPP IV in Caco-2
2) Confidence 0.42 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.14
Upon activation with anti-CD3, up-regulation of both membrane CD26, as well as of DPPIV enzyme activity on R1.1 cells were observed.
Positive_regulation (activation) of DPPIV
3) Confidence 0.27 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.34
Upon activation with anti-CD3, up-regulation of both membrane CD26, as well as of DPPIV enzyme activity on R1.1 cells were observed.
Positive_regulation (up-regulation) of DPPIV
4) Confidence 0.27 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.34
Collectively, cells of immature T cell line, R1.1 exert strong DPPIV enzyme activity, which could be down-regulated in the presence of dynorphin-A(1-17) by mechanism that presumably includes non-substrate inhibition.
Positive_regulation (exert) of DPPIV in immature T cell associated with dynorphin
5) Confidence 0.27 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.70
In the hypothalamus both prolyl endopeptidase and dipeptidyl peptidase IV activities were concomitantly increased.
Positive_regulation (increased) of peptidase IV in hypothalamus
6) Confidence 0.20 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882344 Disease Relevance 0.17 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox