INT61818

Context Info Confidence 0.23 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 4.11 Pain Relevance 0.22

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency long bones 1 OCL 1 keratinocytes 1 vertebrae 1 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Pain 3 93.00 cytokine 16 76.24 Crohn's disease 4 57.68 Inflammation 36 53.00 Inflammatory response 5 5.00 member 8 2 5.00 anesthesia 2 5.00 Versed 2 5.00 tetrodotoxin 1 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Multiple Myeloma 24 99.78 Colitis 31 99.46 Congenital Anomalies 12 98.96 Hypercalcemia 24 94.64 Spontaneous Fractures 3 93.88 Pain 3 93.00 Osteolysis 3 91.20 Diabetic Angiopathy 1 90.32 Injury 4 83.92 Aging 4 82.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Results of fluorescein angiography, Evans blue extravasation, and western blotting for association of the tight junction proteins occludin and zo-1 suggest that endogenous TGF-?

Positive_regulation (Results) of occludin

1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.36 Pain Relevance 0

This hypothesis is consistent with recently published data regarding the antrum mucosal protein (AMP)-18 that ameliorates DSS colitis in mice and also enhances accumulation of occludin and ZO-1 in TJ domains in vitro [55].

Positive_regulation (accumulation) of occludin associated with colitis

2) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.65 Pain Relevance 0.03

When confluent keratinocytes from wild-type mice were stimulated with FGF7, a slight increase in the levels of occludin and a stronger increase in claudin 1 and claudin 3 were observed, which indicates that these genes are targets of FGFs in keratinocytes (Fig. 9 B).

Positive_regulation (increase) of occludin in keratinocytes

3) Confidence 0.20 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.19 Pain Relevance 0.03

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Positive_regulation (increased) of OCL in long bones

4) Confidence 0.15 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

The bone destruction in multiple myeloma is due to increased osteoclast (OCL) activity and decreased bone formation in areas of bone adjacent to myeloma cells.

Positive_regulation (increased) of OCL in OCL associated with multiple myeloma

5) Confidence 0.15 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 1.25 Pain Relevance 0.09

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Positive_regulation (increased) of OCL in vertebrae

6) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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