INT61820

Context Info Confidence 0.15 First Reported 1996 Last Reported 1996 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.65 Pain Relevance 0.08

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency long bones 3 vertebrae 1 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 4 76.88 Pain 2 28.68

Disease Link Frequency Relevance Heat Hypercalcemia 16 88.00 Multiple Myeloma 16 75.00 Bone Cancer 6 75.00 Paralysis 2 65.28 Severe Combined Immunodeficiency 6 51.40 Osteolysis 2 41.48 Spontaneous Fractures 2 29.56 Pain 2 28.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Positive_regulation (increased) of Negative_regulation (numbers) of OCL in long bones

1) Confidence 0.15 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Positive_regulation (increased) of in vertebrae Negative_regulation (numbers) of OCL in long bones

2) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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