INT61822

Context Info Confidence 0.41 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 8 Total Number 8 Disease Relevance 5.33 Pain Relevance 0.45

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency long bones 2 vertebrae 2 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 55 97.80 Crohn's disease 4 91.40 Inflammation 100 85.04 cytokine 21 76.88 cva 1 75.56 Pain 4 29.80 chemokine 3 24.56 imagery 12 5.00 Inflammatory response 6 5.00 fibrosis 3 5.00

Disease Link Frequency Relevance Heat Colitis 31 97.90 Apoptosis 73 96.84 Disease 39 91.40 Hypercalcemia 32 89.12 Weight Loss 2 87.28 Injury 10 85.88 INFLAMMATION 103 85.04 Alopecia 3 83.68 Pulmonary Disease 34 81.72 Asthma 39 81.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is even possible that apical epithelial junction proteins including occludin can be reduced without undue effects on epithelial barrier function.

Negative_regulation (reduced) of occludin

1) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.45 Pain Relevance 0.03

Furthermore, while we observed decreases in microvessel occludin following VP2121–130 peptide administration, Claudin-5 levels dramatically increased.

Negative_regulation (decreases) of occludin

2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.49 Pain Relevance 0.14

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Negative_regulation (numbers) of OCL in long bones

3) Confidence 0.14 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Negative_regulation (loss) of OCL in long bones

4) Confidence 0.14 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.83 Pain Relevance 0.04

Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].

Negative_regulation (decrease) of occludin associated with colitis

5) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

Western blot analysis of epidermal lysates confirmed the down-regulation of claudin 3 and occludin at the protein level and also revealed reduced claudin-1 expression in K5-R1/R2 mice (Fig. 8 C).

Negative_regulation (down-regulation) of occludin

6) Confidence 0.08 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.31 Pain Relevance 0.04

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Negative_regulation (loss) of OCL in vertebrae

7) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.83 Pain Relevance 0.04

Histologic examination of tissues from the ARH-77 mice showed infiltration of myeloma cells in the liver and spleen and marked infiltration in vertebrae and long bones, with loss of bony trabeculae and increased OCL numbers.

Negative_regulation (numbers) of OCL in vertebrae

8) Confidence 0.05 Published 1996 Journal Blood Section Abstract Doc Link 8608240 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

This test has worked.