INT61845

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.28
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
B cell 1
neurons 1
striatum 1
brain 1
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 99.70 Very High Very High Very High
Opioid 7 98.94 Very High Very High Very High
cINOD 6 98.60 Very High Very High Very High
Inflammation 89 96.48 Very High Very High Very High
Glutamate receptor 2 93.04 High High
corticosteroid 1 89.20 High High
TRP channel 1 79.68 Quite High
Morphine 6 75.00 Quite High
Spinal cord 2 75.00 Quite High
aspirin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Convulsion 2 98.64 Very High Very High Very High
Stress 7 97.40 Very High Very High Very High
INFLAMMATION 92 96.48 Very High Very High Very High
Crystal Associated Disease 124 95.64 Very High Very High Very High
Necrosis 6 87.40 High High
Lymphatic System Cancer 16 87.20 High High
Cancer 8 87.04 High High
Leukemia 4 78.24 Quite High
Shock 16 78.04 Quite High
Anxiety Disorder 29 62.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the vesl-1L mRNA (long form) is constitutively expressed.
Transcription (expressed) of vesl-1L
1) Confidence 0.72 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.09
The expression of immediate early gene (nur77) mRNA increased in paraventricular nucleus neurons after stress exposure in virgin and lactating, but not pregnant, mice.
Transcription (expression) of immediate early gene in neurons associated with stress
2) Confidence 0.30 Published 2003 Journal Endocrinology Section Abstract Doc Link 12960085 Disease Relevance 0.39 Pain Relevance 0.10
Although M2 is completely dispensable for MHV68 replication in permissive cell lines [18],[21], we next assessed whether it might play a B cell-specific role in activating transcription from the immediate-early gene 50 promoter which encodes the essential lytic switch protein RTA.
Transcription (transcription) of immediate-early gene in B cell
3) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.09 Pain Relevance 0
Acute treatment with PDE10A inhibitors produces rapid and transient transcription of the immediate early gene cfos in rat striatum.
Transcription (transcription) of immediate early gene in striatum
4) Confidence 0.06 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.13
These findings confirmed induction of IL-6 mRNA in the membrane and identified the 1-hour time point as the peak of a rapid, early surge in proinflammatory cytokine and immediate early gene transcription.
Transcription (transcription) of early gene associated with cytokine
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.37 Pain Relevance 0.05
The appearance of these mRNAs after an initial surge in proinflammatory and immediate early gene transcription suggests that they may form part of a 'second wave' of factors that amplify or perpetuate acute inflammation.


Transcription (transcription) of early gene associated with inflammation
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.12 Pain Relevance 0.28
However, it has been shown that opioids can activate specific signaling pathways and induce immediate early gene (IEG) transcription in brain.
Transcription (transcription) of immediate early gene in brain associated with opioid
7) Confidence 0.04 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673793 Disease Relevance 0 Pain Relevance 0.46
The immediate early gene (IEG) transcription factor c-fos coordinates changes in the pattern of long term gene expression and, therefore, it may be involved in mediating epigenetic control during neurodevelopment.
Transcription (transcription) of immediate early gene
8) Confidence 0.02 Published 1995 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8612322 Disease Relevance 0 Pain Relevance 0.18
Our findings indicate that ribosomal S6 kinase 2 (RSK2), a 90-kDa ribosomal S6 kinase with a critical role as an effector of the RAS-mitogen-activated protein kinase pathway and a regulator of immediate early gene transcription is a target for inhibition by the NSAIDs.
Transcription (transcription) of early gene associated with cinod
9) Confidence 0.00 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.15 Pain Relevance 0.57

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