INT61864

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Context Info
Confidence 0.62
First Reported 1996
Last Reported 2010
Negated 4
Speculated 8
Reported most in Abstract
Documents 24
Total Number 34
Disease Relevance 13.27
Pain Relevance 14.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
dorsal horn 14
retina 10
striatum 4
hippocampus 4
spinal cord 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 297 100.00 Very High Very High Very High
Glutamate 227 100.00 Very High Very High Very High
Inflammation 218 100.00 Very High Very High Very High
cocaine 7 100.00 Very High Very High Very High
tetrodotoxin 7 100.00 Very High Very High Very High
Dorsal horn neuron 93 99.80 Very High Very High Very High
nMDA receptor 515 99.52 Very High Very High Very High
Hippocampus 260 99.52 Very High Very High Very High
Dopamine 119 99.52 Very High Very High Very High
amygdala 7 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 696 100.00 Very High Very High Very High
INFLAMMATION 215 100.00 Very High Very High Very High
Aging 343 99.68 Very High Very High Very High
Injury 11 99.04 Very High Very High Very High
Inflammatory Pain 198 98.80 Very High Very High Very High
Hyperalgesia 16 98.24 Very High Very High Very High
Cold Sores 4 97.66 Very High Very High Very High
Herpes Simplex Virus 2 96.46 Very High Very High Very High
Syndrome 7 96.12 Very High Very High Very High
Pain 53 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant changes in DRG glutamate receptor expression were seen for alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid, kainite, and N-methyl-D aspartate receptors.
Regulation (changes) of Gene_expression (expression) of DRG glutamate receptor in DRG
1) Confidence 0.62 Published 2005 Journal Spine Section Body Doc Link 15770173 Disease Relevance 0 Pain Relevance 0
To analyze the effect of mTOR and BDNF inhibition on GluR1 expression levels, IA-trained rats received bilateral intra-CA1 infusions of rapamycin (4.3 pg/side), anti-BDNF (0.5 ug/side) or saline 15 min before training and were killed by decapitation 15 min thereafter.
Spec (analyze) Regulation (effect) of Spec (analyze) Gene_expression (expression) of GluR1 associated with decapitation
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.15 Pain Relevance 0.08
It is unclear, however, whether there are changes in glutamate receptor gene expression associated with tissue injury.
Spec (whether) Regulation (changes) of Gene_expression (expression) of glutamate receptor gene associated with glutamate receptor and injury
3) Confidence 0.58 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295247 Disease Relevance 0.69 Pain Relevance 0.50
Inflammatory pain is thought to induce functional plasticity of spinal dorsal horn neurons and may produce changes in glutamate receptor expression.
Regulation (changes) of Gene_expression (expression) of glutamate receptor in neurons associated with glutamate receptor, ipn and dorsal horn neuron
4) Confidence 0.55 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17912745 Disease Relevance 0.40 Pain Relevance 0.64
We then examined whether CFA-induced peripheral inflammation altered expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
Regulation (altered) of Gene_expression (expression) of GluR1 in dorsal horn associated with inflammation and dorsal horn
5) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.60 Pain Relevance 0.69
An unexpected observation in the current study was that CFA injection did not produce a marked change in the levels of GluR1 and GluR2 in subcellular fractions from dorsal horn at 2 h post-CFA injection.
Regulation (change) of Gene_expression (levels) of GluR1 in dorsal horn associated with dorsal horn
6) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.25 Pain Relevance 0.41
We therefore examined the effect of repeated cocaine treatment on glutamate receptor subunit expression in central dopamine (DA) pathways implicated in many of cocaine's behavioral actions.
Spec (examined) Regulation (effect) of Gene_expression (expression) of glutamate receptor associated with dopamine, glutamate receptor and cocaine
7) Confidence 0.49 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.07 Pain Relevance 0.62
Modulation of glutamate receptor expression by gonadal steroid hormones in the rat striatum.
Regulation (Modulation) of Gene_expression (expression) of glutamate receptor in striatum associated with glutamate receptor
8) Confidence 0.48 Published 2003 Journal Brain Res. Bull. Section Title Doc Link 12464400 Disease Relevance 0 Pain Relevance 0.35
To determine if this effect was dependent on modulation of glutamate receptor gene expression, we studied the effect of gonadal hormones on levels of the NR1 subunit of NMDA receptor and the GluR2 subunit of the AMPA-subtype of glutamate receptor in the rat striatum, using autoradiographic immunocytochemistry.
Regulation (modulation) of Gene_expression (expression) of glutamate receptor in striatum associated with nmda receptor and glutamate receptor
9) Confidence 0.48 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12464400 Disease Relevance 0 Pain Relevance 0.36
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Regulation (altered) of Gene_expression (expression) of GluR1 associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
10) Confidence 0.44 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.51 Pain Relevance 1.05
These results indicate that GluR1 targeting is a dynamic process that can be differentially affected in distinct amygdala regions in response to chronic self-administration of morphine.
Regulation (affected) of Gene_expression (targeting) of GluR1 in amygdala associated with amygdala and morphine
11) Confidence 0.44 Published 2005 Journal Synapse Section Abstract Doc Link 16037950 Disease Relevance 0 Pain Relevance 0.96
The effects of axotomy or TTX block on motoneuron expression of the metabotropic glutamate receptor mGluR1a were also studied. mGluR1a-ir was also strongly decreased after axotomy but not after TTX treatment.
Regulation (effects) of Gene_expression (expression) of GluR1 in motoneuron associated with tetrodotoxin and glutamate receptor
12) Confidence 0.44 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10982465 Disease Relevance 0.16 Pain Relevance 0.81
These observations show that during ultraviolet irradiation induced inflammation, the synthesis of mGluR3 messenger RNA is altered suggesting that regulation of metabotropic glutamate receptor expression may be instrumental in plastic changes within the spinal cord during the development of hyperalgesia and pain.
Regulation (regulation) of Gene_expression (expression) of glutamate receptor in spinal cord associated with pain, hyperalgesia, inflammation, glutamate receptor and spinal cord
13) Confidence 0.40 Published 1998 Journal Neuroscience Section Abstract Doc Link 9466463 Disease Relevance 0.62 Pain Relevance 0.68
OBJECTIVE: This study was aimed to evaluate the effects of morphine on hypothalamo-pituitary-adrenocortical (HPA) axis, namely proopiomelanocortin (POMC) mRNA and plasma corticosterone, in relation to its influence on glutamate receptor gene expression in central and peripheral sites related to HPA axis regulation.
Regulation (influence) of Gene_expression (expression) of glutamate receptor in pituitary associated with glutamate receptor and morphine
14) Confidence 0.40 Published 2001 Journal Endocr Regul Section Abstract Doc Link 11858765 Disease Relevance 0 Pain Relevance 0.39
To further define the involvement of spinal cord AMPARs in persistent inflammatory pain, we examined whether CFA-induced inflammation produced the changes in expression of total GluR1 and GluR2 proteins in total soluble fraction derived from dorsal horn.
Regulation (changes) of Gene_expression (expression) of GluR1 in dorsal horn associated with inflammation, eae, dorsal horn and spinal cord
15) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.36 Pain Relevance 0.64
Thus, the main purpose of this study was to investigate whether diabetes changes the expression of ionotropic glutamate receptor subunits in the retina, and to determine if changes at the protein level were associated with changes at the gene expression level.
Spec (whether) Regulation (changes) of Gene_expression (expression) of glutamate receptor in retina associated with diabetes mellitus and glutamate receptor
16) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.66 Pain Relevance 0.33
CFA-induced inflammation did not change total expression or distribution of AMPAR subunits GluR1 and GluR2 in dorsal horn but did alter their subcellular distribution.
Neg (not) Regulation (change) of Gene_expression (expression) of GluR1 in dorsal horn associated with inflammation and dorsal horn
17) Confidence 0.34 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.55 Pain Relevance 0.52
In the brain of streptozotocin (STZ)-induced diabetic rats, the binding properties of AMPA receptors and the expression of GluR1 subunit are decreased [16], without changes in the transcript levels of GluR1, GluR2/3, NR1, and NR2A subunits after three months of diabetes [17].
Regulation (properties) of Gene_expression (expression) of GluR1 in brain associated with diabetes mellitus
18) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.80 Pain Relevance 0.36
While they do report significant decreases in GluR2 and GluR3 subunits, there are no significant changes in GluR1 expression (see Supplementary Material Figure 4a; Wright et al., 2008).
Neg (no) Regulation (changes) of Gene_expression (expression) of GluR1
19) Confidence 0.30 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.09 Pain Relevance 0.13
Effect of CFA-induced peripheral inflammation on the levels of GluR1 and GluR2 proteins in plasma membrane fraction and cytosolic fraction from dorsal horn
Regulation (Effect) of Gene_expression (levels) of GluR1 in dorsal horn associated with inflammation and dorsal horn
20) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.26 Pain Relevance 0.40

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