INT61866

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.02
Pain Relevance 7.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
DA neurons 2
tail 2
dopamine neurons 2
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 474 100.00 Very High Very High Very High
depression 362 100.00 Very High Very High Very High
Dopamine 200 100.00 Very High Very High Very High
Glutamate receptor 9 100.00 Very High Very High Very High
Cannabinoid 216 99.98 Very High Very High Very High
gABA 48 99.96 Very High Very High Very High
Morphine 24 98.88 Very High Very High Very High
Eae 17 97.80 Very High Very High Very High
long-term potentiation 96 96.96 Very High Very High Very High
Nicotine 66 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 362 100.00 Very High Very High Very High
Li-fraumeni Syndrome 64 100.00 Very High Very High Very High
Cold Sores 8 100.00 Very High Very High Very High
Herpes Simplex Virus 5 99.62 Very High Very High Very High
Stress 19 98.84 Very High Very High Very High
Nociception 1 96.00 Very High Very High Very High
Drug Dependence 24 5.00 Very Low Very Low Very Low
Cannabis Dependence 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Recurrence 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identifying precisely how these lesions influence the dynamics of neuronal interactions in the VTA—do they affect a direct nicotinic activation of DA neurons or is the effect mediated through GABA?
Positive_regulation (through) of Gene_expression (do) of VTA in DA neurons associated with ventral tegmentum, gaba and dopamine
1) Confidence 0.36 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.60
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Positive_regulation (overexpression) of Gene_expression (overexpression) of VTA associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
2) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 1.01
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Positive_regulation (causes) of Gene_expression (overexpression) of VTA associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
3) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 1.01
Increased glutamate receptor subunit expression in the VTA may represent an important molecular mechanism by which drugs of abuse and stress exert common, long-term effects on mesolimbic DA function.
Positive_regulation (Increased) of Gene_expression (expression) of VTA associated with stress, ventral tegmentum, dopamine and glutamate receptor
4) Confidence 0.19 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.49 Pain Relevance 1.00
Second, the AMPAR/NMDAR ratio of glutamatergic synaptic currents in VTA dopamine neurons was significantly smaller at 30 min (0.44±0.05; n?
Positive_regulation (/) of Gene_expression (dopamine neurons) of VTA in dopamine neurons associated with ventral tegmentum and dopamine
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.75 Pain Relevance 0.92
To determine whether systemically applied TAT-GluR2 peptide disrupted CPP acquisition by its action in the VTA, we conducted intra-VTA infusion of the peptide (15 pmol) 60 min before each HU210 injection during conditioning (Figure 6B).
Positive_regulation (conducted) of Gene_expression (infusion) of intra-VTA associated with ventral tegmentum
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.38 Pain Relevance 0.63
The pivotal role of GluR2 endocytosis in cannabinoid-facilitated LTD expression in the VTA is supported by our findings that bath application of TAT-GluR2, but not its scrambled sequence, blocked LTD expression in HU210-treated rats (Figure 4C,D).
Positive_regulation (facilitated) of Gene_expression (expression) of VTA associated with ventral tegmentum, depression and cannabinoid
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.68 Pain Relevance 1.25
After a bilateral injection of the vectors into the major part of the VTA (Figure 2B), the CB1R shRNA, but not its scrambled sequence, significantly suppressed CB1R expression in the VTA (Figure 2C) and LFS-induced LTD in HU210-treated rats (Figure 2D,E).
Positive_regulation (induced) of Gene_expression (expression) of VTA associated with ventral tegmentum, li-fraumeni syndrome and depression
8) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.96 Pain Relevance 1.15
Using herpes simplex virus-mediated gene transfer to assess the functional significance of this ERK induction, we show that overexpressing ERK2 within the VTA increases susceptibility to stress as measured in the forced swim test, responses to unconditioned nociceptive stimuli, and elevated plus maze in Sprague Dawley male rats, and in the tail suspension test and chronic social defeat stress procedure in C57BL/6 male mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VTA in tail associated with nociception, stress, ventral tegmentum, herpes simplex virus and eae
9) Confidence 0.11 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519540 Disease Relevance 0.85 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox