INT61873

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2010
Negated 9
Speculated 0
Reported most in Body
Documents 128
Total Number 128
Disease Relevance 128.25
Pain Relevance 52.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
neurons 44
spinal cord 12
dorsal horn 5
gonadal 4
spinal 3
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1714 100.00 Very High Very High Very High
Morphine 65 100.00 Very High Very High Very High
tolerance 10 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
Neuropathic pain 272 99.96 Very High Very High Very High
intrathecal 680 99.92 Very High Very High Very High
projection neuron 204 99.88 Very High Very High Very High
Dorsal horn neuron 408 99.84 Very High Very High Very High
GABAergic 399 99.84 Very High Very High Very High
bDMF 1224 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 11623 100.00 Very High Very High Very High
Neuropathic Pain 476 99.96 Very High Very High Very High
Nociception 2795 99.72 Very High Very High Very High
Inflammatory Pain 273 99.52 Very High Very High Very High
Targeted Disruption 2392 99.48 Very High Very High Very High
Nervous System Injury 408 99.40 Very High Very High Very High
Pain 1919 99.24 Very High Very High Very High
INFLAMMATION 361 98.92 Very High Very High Very High
Neuroblastoma 5 98.56 Very High Very High Very High
Hyperalgesia 204 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition experiments revealed that morphine induced Arc expression in Neuro2A MOR1A cells via intracellular signaling pathways involving mitogen-activated protein (MAP) kinases and protein kinase C.
Gene_expression (expression) of Arc associated with kinase c, aids-related complex and morphine
1) Confidence 0.78 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.86 Pain Relevance 1.26
In the present experiments, the influence of morphine on Arc expression was assessed by quantitative reverse transcription real-time PCR and Western blotting in vivo in the mouse striatum/nucleus accumbens and, in vitro, in the mouse Neuro2A MOR1A cell line, expressing mu-opioid receptor.
Gene_expression (expression) of Arc in nucleus accumbens associated with nucleus accumbens, aids-related complex, opioid receptor and morphine
2) Confidence 0.78 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.63 Pain Relevance 0.80
Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.
Gene_expression (expression) of Arc in striatum associated with neuroblastoma, aids-related complex, mu opioid receptor and morphine
3) Confidence 0.78 Published 2005 Journal J. Neurosci. Res. Section Title Doc Link 16211563 Disease Relevance 0.71 Pain Relevance 0.87
After prolonged opiate treatment, tolerance to the stimulatory effect of morphine on Arc expression developed.
Gene_expression (expression) of Arc associated with aids-related complex, tolerance, opiate and morphine
4) Confidence 0.68 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.89 Pain Relevance 1.23
associated protein/activity-regulated gene 3.1 (Arc/Arg3.1), and Zif268 (also
Gene_expression (/) of Arg3.1 associated with aids-related complex
5) Confidence 0.65 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.19
Basal zif268 and arc mRNAs expression was reduced in mutant mice by 60-80%, not only in the striatum but also widespread in the cerebral cortex and hippocampus.
Gene_expression (expression) of arc in hippocampus associated with aids-related complex, hippocampus and cerebral cortex
6) Confidence 0.65 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.10 Pain Relevance 0.55
Since we found a low level of colocalization of Arc/Arg3.1 with GABAergic neurons, it is not unlikely that several of the enkephalinergic neurons in the spinal cord that express Arc/Arg3.1 also use glutamate as a transmitter.
Gene_expression (express) of Arc/Arg3.1 in GABAergic neurons associated with glutamate, aids-related complex, gabaergic and spinal cord
7) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.87 Pain Relevance 1.30
This assumption is in line with our finding that Arc/Arg3.1 expression is intensity dependent.
Gene_expression (expression) of Arc/Arg3.1 associated with aids-related complex
8) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.43 Pain Relevance 0.53
Following nociceptive stimulation, Arc/Arg3.1 was often expressed in activated neurons as identified by c-Fos.
Gene_expression (expressed) of Arc/Arg3.1 in neurons associated with nociception and aids-related complex
9) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.46 Pain Relevance 0.79
Since to date there is no evidence for the colocalization of these substances with each other, we conclude that Arc/Arg3.1 is preferentially expressed in the subpopulation of enkephalinergic neurons.
Gene_expression (expressed) of Arc/Arg3.1 in neurons associated with aids-related complex
10) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.79 Pain Relevance 0.82
The low number of spinal projection neurons that express Arc/Arg3.1 may be explained by the fact that, in contrast to other areas of the brain, structural long-term changes in the excitability of these spinal neurons are counterproductive if they persist after the healing process has been completed.
Gene_expression (express) of Arc/Arg3.1 in spinal associated with aids-related complex and projection neuron
11) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.88 Pain Relevance 1.23
In order to ascertain that Arc/Arg3.1 is expressed in neurons rather than in glial cells, we combined FISH for Arc/Arg3.1 mRNA with fluorescent IHC for NeuN, which is a specific marker for neuronal cells (Fig. 1D).
Gene_expression (expressed) of Arc/Arg3.1 in neuronal associated with aids-related complex
12) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.11 Pain Relevance 0.27
This is in line with Arc/Arg3.1 expression in cultured neurons following BDNF application [18].
Gene_expression (expression) of Arc/Arg3.1 in neurons associated with aids-related complex and bdmf
13) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.17 Pain Relevance 0.86
Therefore, our data indicate that the number of neurons expressing Arc/Arg3.1 depends on the intensity of the stimulus, but is not limited to the activation of one specific receptor on peripheral nerves.
Gene_expression (expressing) of Arc/Arg3.1 in neurons associated with aids-related complex
14) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.28 Pain Relevance 0.90
The number of neurons expressing the neuronal activation marker c-Fos or Arc/Arg3.1 mRNA was counted in separate sections treated with IHC or ISH, respectively. c-Fos labeled neurons outnumbered Arc/Arg3.1 mRNA labeled neurons (Fig. 3A), except after 2 hrs mustard oil stimulation when about equal number of neurons were labeled.
Gene_expression (expressing) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex
15) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.00 Pain Relevance 0.20
In the hippocampal and neocortical neurons expression of Arc/Arg3.1 in GABAergic positive neurons is also low but this is not the case in the dorsal striatum [20].
Gene_expression (expression) of Arc/Arg3.1 in neurons associated with aids-related complex and gabaergic
16) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.94 Pain Relevance 0.79
However, in the present study a significant increase in the number of Arc/Arg3.1 mRNA expressing neurons could not be confirmed after intrathecal injection of BDNF and NBQX together.
Gene_expression (expressing) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex, bdmf and intrathecal
17) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.31 Pain Relevance 0.92
The same study showed a significantly enhanced expression of Arc/Arg3.1 mRNA when NBQX, a potent AMPA receptor blocker, was applied together with BDNF.
Gene_expression (expression) of Arc/Arg3.1 mRNA associated with aids-related complex and bdmf
18) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.23 Pain Relevance 0.81
The number of neurons producing Arc/Arg3.1 mRNA varied in the different pain models, and increasing the intensity of the pain stimulus resulted in an increased number of neurons expressing Arc/Arg3.1 as shown in the mustard oil experiments.
Gene_expression (expressing) of Arc/Arg3.1 in neurons associated with pain and aids-related complex
19) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.30 Pain Relevance 0.87
It was found that 95% ± 1.3 (SEM) of the cells expressing Arc/Arg3.1 mRNA also expressed NeuN (99% ± 0.4 for 25% MO/1 h, n = 4; 95% ± 3.3 for 25% MO/2 hrs, n = 5; 94% ± 2.8 for CFA for 1.5 hrs, n = 4).
Gene_expression (expressing) of Arc/Arg3.1 mRNA associated with aids-related complex
20) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.90 Pain Relevance 0.06

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