INT61874

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Context Info
Confidence 0.27
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
neurons 2
gonads 2
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 100.00 Very High Very High Very High
Morphine 7 99.50 Very High Very High Very High
Enkephalin 2 92.16 High High
opioid receptor 3 82.52 Quite High
tolerance 3 75.00 Quite High
mu opioid receptor 2 72.72 Quite High
antagonist 1 69.76 Quite High
Opioid 1 25.00 Low Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 88 100.00 Very High Very High Very High
Reprotox - General 2 1 100.00 Very High Very High Very High
Injury 2 5.00 Very Low Very Low Very Low
Feminization 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pubertal increase in kisspeptin would normally initiate increased GnRH release and thereby lead to activation of the gonads; however, in WT mice, this increase in ARC Kiss1 mRNA is not appreciated.
Neg (not) Negative_regulation (appreciated) of Positive_regulation (increase) of ARC in gonads associated with aids-related complex
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.63 Pain Relevance 0
Chronic morphine treatment caused both a decreased potency (EC50 220 +/- 10 nM vs. 64 +/- 3 nM in controls) and a decreased efficacy (Vmax: -7.1 +/- 1.1 mV vs. -10.7 +/- 0.6 mV in controls) of DAMGO in a population of ARC neurons including beta-endorphin neurons.
Negative_regulation (decreased) of Positive_regulation (population) of ARC in neurons associated with reprotox - general 2, aids-related complex, potency and morphine
2) Confidence 0.08 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613967 Disease Relevance 0.53 Pain Relevance 0.79

General Comments

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