INT61875

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Context Info
Confidence 0.34
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.61
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
hypothalamus 1
dentate gyrus 1
hippocampus 1
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 37 99.98 Very High Very High Very High
Hyperalgesia 4 99.56 Very High Very High Very High
long-term potentiation 27 99.24 Very High Very High Very High
central sensitization 4 98.78 Very High Very High Very High
antagonist 2 98.78 Very High Very High Very High
mu opioid receptor 2 98.22 Very High Very High Very High
Morphine 7 98.12 Very High Very High Very High
Spinal cord 50 98.04 Very High Very High Very High
Pain 42 96.76 Very High Very High Very High
depression 15 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 271 100.00 Very High Very High Very High
Hyperalgesia 6 99.56 Very High Very High Very High
Cognitive Disorder 21 98.76 Very High Very High Very High
Pain 56 96.76 Very High Very High Very High
Depression 15 96.40 Very High Very High Very High
Hypersensitivity 2 95.82 Very High Very High Very High
Targeted Disruption 73 95.22 Very High Very High Very High
Inflammatory Pain 8 91.88 High High
Neuropathic Pain 14 87.96 High High
Nociception 82 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our finding that Arc/Arg3.1 KO mice develop hypersensitivity in acute and chronic pain models in the same way as their WT littermates, suggests that the LTP formation that contributes to central sensitization and subsequent developing hyperalgesia is unaffected by the lack of Arc/Arg3.1.
Negative_regulation (lack) of Arc/Arg3.1 associated with targeted disruption, hyperalgesia, central sensitization, aids-related complex, lasting pain, hypersensitivity and long-term potentiation
1) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 2.07 Pain Relevance 1.31
Several studies have shown that in hippocampus knockdown of Arc/Arg3.1 leads to enhanced LTP in the early phase but impaired consolidation of LTP and long term depression (LTD) in the late phase [13].
Negative_regulation (knockdown) of Arc/Arg3.1 in hippocampus associated with depression, aids-related complex, long-term potentiation and hippocampus
2) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 2.35 Pain Relevance 1.09
For example, object exploration also increases Arc, CaMKII and PSD95 expression in the dentate gyrus (Soulé et al., 2008) and both Arc and CaMKII inactivation in mutant mice have deficient object recognition memory (Miller et al., 2002; Plath et al., 2006).
Negative_regulation (inactivation) of Arc in dentate gyrus associated with cognitive disorder and aids-related complex
3) Confidence 0.16 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.54 Pain Relevance 0
The density of mu-opioid receptors labeled with the antagonist radioligand [3H]diprenorphine was found to be significantly decreased in the ARC and surrounding mediobasal hypothalamus after morphine treatment (Bmax: 217 +/- 9 vs. 276 +/- 16 fmol/mg protein in controls), which is consistent with the altered response in beta-endorphin neurons.
Negative_regulation (decreased) of ARC in hypothalamus associated with aids-related complex, antagonist, mu opioid receptor and morphine
4) Confidence 0.07 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613967 Disease Relevance 0.64 Pain Relevance 1.08

General Comments

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