INT61890

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.30
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
liver 2
NG108-15 2
neurons 1
acinar cells 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 4 100.00 Very High Very High Very High
fortral 12 99.74 Very High Very High Very High
agonist 13 97.52 Very High Very High Very High
antagonist 14 88.00 High High
narcan 2 79.28 Quite High
cocaine 2 77.28 Quite High
Opioid 1 75.00 Quite High
Enkephalin 1 40.80 Quite Low
antidepressant 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 2 86.80 High High
Psychosis 2 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although protein release from acinar cells has been attributed to either muscarinic or alpha-adrenergic stimulation, protein release from sigma-receptor stimulation was also confirmed.
Localization (release) of sigma-receptor in acinar cells
1) Confidence 0.40 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614245 Disease Relevance 0.30 Pain Relevance 0.32
By combining immunocytochemistry and real-time monitoring of enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) in living cells, we characterized the sigma-1 receptor translocation in this study. (+)-Pentazocine, a selective sigma-1 receptor agonist, causes a significant decrease of sigma-1 receptors in ER-LDs and a diffused distribution of sigma-1 receptors over the entire endoplasmic reticulum reticular network in NG108-15 cells.
Localization (translocation) of Sig-1R-EYFP in NG108-15 associated with fortral and agonist
2) Confidence 0.28 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730356 Disease Relevance 0 Pain Relevance 0.22
By combining immunocytochemistry and real-time monitoring of enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) in living cells, we characterized the sigma-1 receptor translocation in this study. (+)-Pentazocine, a selective sigma-1 receptor agonist, causes a significant decrease of sigma-1 receptors in ER-LDs and a diffused distribution of sigma-1 receptors over the entire endoplasmic reticulum reticular network in NG108-15 cells.
Localization (translocation) of sigma-1 receptor in NG108-15 associated with fortral and agonist
3) Confidence 0.28 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730356 Disease Relevance 0 Pain Relevance 0.22
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions.
Localization (retention) of sigma 1 in liver associated with fortral
4) Confidence 0.21 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8813603 Disease Relevance 0 Pain Relevance 0.18
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions.
Localization (solubilization) of sigma 1 in liver associated with fortral
5) Confidence 0.21 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8813603 Disease Relevance 0 Pain Relevance 0.18
In a subpopulation of myenteric neurons, delta- and kappa-OPRs seem to be colocalized and may functionally interact.
Localization (colocalized) of OPRs in neurons associated with kappa opioid receptor
6) Confidence 0.03 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14569065 Disease Relevance 0 Pain Relevance 0.38

General Comments

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