INT61891

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Context Info
Confidence 0.32
First Reported 1995
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
ovary 2
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 11 99.94 Very High Very High Very High
Spinal cord 1 95.52 Very High Very High Very High
agonist 7 92.72 High High
fortral 4 42.00 Quite Low
antidepressant 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 2 93.92 High High
Psychosis 2 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, is the action by the presumed antagonist a consequence of sigma-receptor activity?
Positive_regulation (consequence) of sigma-receptor Binding (activity) of associated with antagonist
1) Confidence 0.32 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614245 Disease Relevance 0.34 Pain Relevance 0.34
When expressed in Chinese hamster ovary (CHO) cells, the level of sigma1 binding increased markedly, and the binding profile was consistent with sigma1 sites.
Positive_regulation (increased) of sigma1 Binding (binding) of in ovary
2) Confidence 0.12 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11434908 Disease Relevance 0 Pain Relevance 0.05

General Comments

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