INT619

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 116
Total Number 119
Disease Relevance 22.69
Pain Relevance 45.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 36
thyroid 14
pituitary 12
blood 8
5-HT neurons 8
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 163 100.00 Very High Very High Very High
Morphine 116 100.00 Very High Very High Very High
Opioid 72 100.00 Very High Very High Very High
Serotonin 57 99.84 Very High Very High Very High
Enkephalin 48 99.84 Very High Very High Very High
ketamine 1 99.84 Very High Very High Very High
alcohol 34 99.70 Very High Very High Very High
antagonist 226 99.58 Very High Very High Very High
Endogenous opioid 35 99.54 Very High Very High Very High
agonist 139 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 264 100.00 Very High Very High Very High
Body Weight 14 100.00 Very High Very High Very High
Headache 32 99.36 Very High Very High Very High
Aids-related Complex 1 99.10 Very High Very High Very High
Rheumatoid Arthritis 38 98.88 Very High Very High Very High
Hemorrhage 4 98.74 Very High Very High Very High
Galactorrhea 54 98.48 Very High Very High Very High
Reprotox - General 2 70 98.36 Very High Very High Very High
Fibromyalgia 5 97.96 Very High Very High Very High
Empty Sella Syndrome 6 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of these results, we suggest that: (1) serum prolactin elevations following 5-HT reuptake blockade plus 5-HTP are correlated with 5-HT concentration in the median eminence; (2) lesion-induced antagonism of 5-HTP-induced prolactin elevation is critically dependent upon complete blockade of median eminence 5-HT accumulation; and (3) 5-HT neurons arising from cell bodies located in the MR and DR are necessary for endogenous serotonergically mediated effects on prolactin secretion in the rat.
Positive_regulation (dependent) of Positive_regulation (elevation) of prolactin in 5-HT neurons
1) Confidence 0.70 Published 1984 Journal Brain Res. Section Abstract Doc Link 6610456 Disease Relevance 0 Pain Relevance 0.22
Thus, at 1900 h of day 21, naloxone induced a significant increase in serum prolactin but, at 2200 h, the opioid antagonist dramatically enhanced the circulating level of prolactin.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin associated with antagonist, narcan and opioid
2) Confidence 0.70 Published 1994 Journal J. Endocrinol. Section Abstract Doc Link 8138757 Disease Relevance 0 Pain Relevance 0.54
The employed stress paradigm also induced an elevation of anterior pituitary levels of PRL and POMC mRNAs.
Positive_regulation (induced) of Positive_regulation (elevation) of PRL in anterior pituitary associated with stress
3) Confidence 0.70 Published 1994 Journal Peptides Section Abstract Doc Link 7984495 Disease Relevance 0.63 Pain Relevance 0.42
The results suggest that endogenous opioids may be involved in the increase in serum level of prolactin induced by 5-hydroxytryptophan and also indicate the existence of different serotonergic neurotransmitter circuits capable of modulating the release of prolactin and corticosterone.
Positive_regulation (increase) of Positive_regulation (induced) of prolactin associated with neurotransmitter and endogenous opioid
4) Confidence 0.70 Published 1983 Journal Life Sci. Section Abstract Doc Link 6602260 Disease Relevance 0 Pain Relevance 0.98
Morphine induced a sudden increase in the PRL level (peaked within 30 minutes) and a gradual decrease in the T level (leveled off within 6.5-10 hours), and then returned to basal levels.
Positive_regulation (induced) of Positive_regulation (increase) of PRL associated with morphine
5) Confidence 0.69 Published 1998 Journal J. Med. Primatol. Section Abstract Doc Link 9606036 Disease Relevance 0.21 Pain Relevance 0.50
Thus, routine experimental manipulations, such as moving the animals to a laboratory and ether exposure, induce significant and variable elevations of serum prolactin in female hamsters.
Positive_regulation (induce) of Positive_regulation (elevations) of serum prolactin
6) Confidence 0.69 Published 1983 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6889312 Disease Relevance 0.07 Pain Relevance 0.07
The prolactin secretory response to morphine gradually returned in dams, so that after 8 days of non-suckling, all animals tested showed a morphine induced prolactin increase.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin associated with morphine
7) Confidence 0.69 Published 1988 Journal Life Sci. Section Abstract Doc Link 3386414 Disease Relevance 0 Pain Relevance 0.70
Morphine, when given intraventricularly to normal males, induced a conspicuous and significant elevation of serum Prl levels at 10, 20, 40 and 60 min after treatment.
Positive_regulation (induced) of Positive_regulation (elevation) of Prl associated with morphine
8) Confidence 0.69 Published 1987 Journal J. Steroid Biochem. Section Abstract Doc Link 2826902 Disease Relevance 0 Pain Relevance 0.85
Pretreatment with naloxone prevented the increase on prolactin levels induced by DAMGO.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin associated with narcan
9) Confidence 0.69 Published 2004 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 15176435 Disease Relevance 0.09 Pain Relevance 0.67
MR-2266-BS of 6 mg/kg significantly increased the resting levels of plasma ACTH and also further elevated the restraint stress-induced increase of plasma ACTH and PRL.
Positive_regulation (elevated) of Positive_regulation (increase) of PRL in plasma associated with stress
10) Confidence 0.68 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2557673 Disease Relevance 0.28 Pain Relevance 0.41
Haloperidol (HAL; 2.5 mg/kg s.c.) treatment had no effect on basal LH release but resulted in a significant increase in PRL which remained elevated up to 180 min.
Positive_regulation (elevated) of Positive_regulation (increase) of PRL
11) Confidence 0.68 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982041 Disease Relevance 0 Pain Relevance 0.69
In rats anesthetized with ketamine, which induces a significant increase of GH, PRL and corticosterone secretion by activating the sympathetic tone, OFQ (23 microg/rat, i.c.v.) did not modify GH and corticosterone levels, whereas again it significantly potentiated PRL secretion.
Positive_regulation (induces) of Positive_regulation (increase) of PRL in sympathetic associated with ketamine
12) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031535 Disease Relevance 0 Pain Relevance 0.38
RESULTS: Fenfluramine challenge induced an increase in mean prolactin and cortisol serum values in both patients and controls.
Positive_regulation (induced) of Positive_regulation (increase) of prolactin
13) Confidence 0.62 Published 1998 Journal Scand. J. Gastroenterol. Section Body Doc Link 9712230 Disease Relevance 0.09 Pain Relevance 0
Interestingly, progesterone treatment (0.5 mg/rat) on days 13, 14 and 15 of pregnancy prevented the high increase in serum prolactin induced by RU-486 and naloxone on day 16 of pregnancy.
Positive_regulation (increase) of Positive_regulation (induced) of serum prolactin associated with narcan
14) Confidence 0.61 Published 1997 Journal J. Endocrinol. Section Abstract Doc Link 9390012 Disease Relevance 0 Pain Relevance 0.60
The selective kappa-opioid receptor agonist U-50, 488H (trans-(+/-)-3,4-dichloro-N-[2(1-pyrrolidinyl)-cyclohexyl]-benzene acetamide methane sulfonate salt) induced a small but significant increase in serum prolactin levels but no effect was observed after administration of the delta-opioid agonist DPDPE ([D-Pen2, D-Pen5]-enkephalin).
Positive_regulation (induced) of Positive_regulation (increase) of serum prolactin associated with mu agonist, agonist, kappa opioid receptor and enkephalin
15) Confidence 0.60 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10355593 Disease Relevance 0.17 Pain Relevance 1.05
On day 19 of pregnancy, intracereboventricular administration of the mu-opioid receptor agonist (D-Ala2, NMe-Phe4, Gly-ol5)-enkephalin (DAMGO) or beta-endorphin (beta-END) induced a dose-related increase in serum prolactin levels 30 min later.
Positive_regulation (induced) of Positive_regulation (increase) of serum prolactin associated with agonist, enkephalin and opioid receptor
16) Confidence 0.60 Published 2004 Journal Neuroendocrinology Section Abstract Doc Link 15340248 Disease Relevance 0 Pain Relevance 0.70
Prl levels in control and MSG-treated rats were similar at 60 min post-anesthesia (bleeding 2) which represented a return of Prl levels to baseline after stress-induced elevation of Prl.
Positive_regulation (stress-induced) of Positive_regulation (elevation) of Prl associated with stress, anesthesia and hemorrhage
17) Confidence 0.50 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1407411 Disease Relevance 0.85 Pain Relevance 0.51
These findings indicate that fenfluramine-induced increases in prolactin are independent of serotonin release, and possibly involve direct post-synaptic actions of fenfluramine or one of its metabolites (norfenfluramine).
Neg (independent) Positive_regulation (independent) of Positive_regulation (increases) of prolactin associated with serotonin
18) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8894606 Disease Relevance 0 Pain Relevance 0.37
These results show that (1) the tuberoinfundibular dopaminergic system is functioning in MSG-treated rats to maintain Prl at low levels, (2) the stimulatory effect of morphine on Prl release is intact in MSG-treated rats, and (3) the tuberoinfundibular dopaminergic system is not responsible for stress-induced Prl release, but rather another mechanism located within the arcuate nucleus (ARC) and highly sensitive to destruction by MSG mediates stress-induced Prl release.
Positive_regulation (mediates) of Positive_regulation (stress-induced) of Prl in arcuate nucleus associated with stress, aids-related complex and morphine
19) Confidence 0.50 Published 1983 Journal Brain Res. Bull. Section Abstract Doc Link 6297690 Disease Relevance 0.37 Pain Relevance 0.23
On the basis of these results, we suggest that: (1) serum prolactin elevations following 5-HT reuptake blockade plus 5-HTP are correlated with 5-HT concentration in the median eminence; (2) lesion-induced antagonism of 5-HTP-induced prolactin elevation is critically dependent upon complete blockade of median eminence 5-HT accumulation; and (3) 5-HT neurons arising from cell bodies located in the MR and DR are necessary for endogenous serotonergically mediated effects on prolactin secretion in the rat.
Positive_regulation (effects) of Positive_regulation (elevation) of prolactin in 5-HT neurons
20) Confidence 0.50 Published 1984 Journal Brain Res. Section Abstract Doc Link 6610456 Disease Relevance 0 Pain Relevance 0.22

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