INT61907

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Context Info
Confidence 0.37
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.77
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ebp) endoplasmic reticulum (Ebp)
Anatomy Link Frequency
germline 1
MLH1 1
Ebp (Mus musculus)
Pain Link Frequency Relevance Heat
epidural 7 99.50 Very High Very High Very High
lidocaine 10 99.18 Very High Very High Very High
aspirin 18 98.52 Very High Very High Very High
action potential duration 8 95.12 Very High Very High Very High
cINOD 11 92.32 High High
agonist 5 90.64 High High
antagonist 2 86.60 High High
headache 3 50.00 Quite Low
intrathecal 1 50.00 Quite Low
Inflammation 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 36 100.00 Very High Very High Very High
Colon Cancer 4 98.00 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 7 97.84 Very High Very High Very High
Cancer 185 95.76 Very High Very High Very High
INFLAMMATION 24 91.64 High High
Breast Cancer 1 90.16 High High
Lymphatic System Cancer 7 88.72 High High
Leukemia 2 88.32 High High
Ovarian Cancer 2 86.48 High High
Colorectal Cancer 26 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, residual lidocaine in the epidural space may contribute to failures of immediate or early EBP.
Negative_regulation (failures) of EBP associated with epidural and lidocaine
1) Confidence 0.37 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8615495 Disease Relevance 0 Pain Relevance 0.89
CONCLUSIONS: The immediate injection of 10 mL intrathecal normal saline after a wet tap significantly reduced the incidence of PDPH and the need for EBP.
Negative_regulation (reduced) of EBP
2) Confidence 0.31 Published 2001 Journal Reg Anesth Pain Med Section Body Doc Link 11464346 Disease Relevance 0 Pain Relevance 0
In contrast, ranolazine completely suppressed TdP but did not cause any shift in the phenylephrine dose-response curve at the highest dose tested (480 microg/kg/min).
Negative_regulation (suppressed) of TdP
3) Confidence 0.23 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18322148 Disease Relevance 0.08 Pain Relevance 0.31
We conclude that ranolazine antagonizes the ventricular repolarization changes caused by clofilium and suppresses clofilium-induced TdP in rabbits.
Negative_regulation (suppresses) of TdP
4) Confidence 0.15 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18322148 Disease Relevance 0.07 Pain Relevance 0.20
These results suggest that NO-ASA derivatives may be more effective at suppressing MSI in MMR-deficient cell lines than ASA and should be considered for chemopreventive trials with HNPCC carriers.
Negative_regulation (suppressing) of MSI associated with microsatellite instability
5) Confidence 0.13 Published 2007 Journal Cancer Res. Section Abstract Doc Link 18006842 Disease Relevance 0.55 Pain Relevance 0.19
Aspirin and sulindac have been shown to be effective in selecting for cells with reduced microsatellite instability (MSI) that is inherent in mismatch repair (MMR)-deficient hereditary nonpolyposis colorectal cancer (HNPCC) cells.
Negative_regulation (reduced) of MSI associated with aspirin, microsatellite instability and hereditary nonpolyposis colorectal neoplasms
6) Confidence 0.13 Published 2007 Journal Cancer Res. Section Abstract Doc Link 18006842 Disease Relevance 0.92 Pain Relevance 0.47
We found that the ASA- and NO-ASA-treated MMR-deficient cell lines displayed a dose-dependent suppression of MSI that appeared as early as 8 weeks and gradually increased to include up to 67% of the microsatellite sequences examined after 19 to 20 weeks of continuous treatment.
Negative_regulation (suppression) of MSI associated with microsatellite instability
7) Confidence 0.13 Published 2007 Journal Cancer Res. Section Abstract Doc Link 18006842 Disease Relevance 0.88 Pain Relevance 0.42
These studies use MSI or loss of immunohistochemical staining as the screening methodology, and therefore identify both germline and sporadic MMR defects.
Negative_regulation (loss) of MSI in germline
8) Confidence 0.09 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.23 Pain Relevance 0
MSI is often a result of the loss or hindrance of DNA MMR, and nearly a third of individuals with colorectal cancers characterized by MSI have hereditary mutations in genes involved with MMR such as MLH1; moreover, 15–20% of the sporadic cases with MSI exhibit hypermethylation of MLH1 (Geigl et al., 2008; Grady and Carethers, 2008).
Negative_regulation (loss) of MSI in MLH1 associated with colon cancer and microsatellite instability
9) Confidence 0.03 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.05 Pain Relevance 0

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