INT61912

Context Info Confidence 0.69 First Reported 1996 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.13 Pain Relevance 0.41

plasma membrane (Fcgr1)

Anatomy Link Frequency monocytes 1 Fcgr1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 28 94.32 nMDA receptor antagonist 3 94.16 long-term potentiation 84 91.20 spinal dorsal horn 50 85.08 Paracetamol 1 64.92 c fibre 28 50.00 Dorsal horn neuron 1 50.00 chemokine 1 44.96 Glutamate receptor 4 10.40 Sciatic nerve 13 5.00

Disease Link Frequency Relevance Heat Acute Chest Syndrome 35 94.44 Disease 4 92.08 Sickle Cell Anemia 46 84.48 Thrombocytopenic Purpura 2 75.00 Targeted Disruption 5 69.52 Nose Bleeds 1 68.88 Ecchymosis 1 68.32 Adult Respiratory Distress Syndrome 1 65.60 Exanthema 1 59.72 Wheal 1 59.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data indicate that intravenous monoclonal antibody 197 induces specific down-modulation of Fc gamma RI expression on monocytes.

Gene_expression (expression) of Fc gamma RI in monocytes

1) Confidence 0.69 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8616043 Disease Relevance 0.39 Pain Relevance 0.06

Additionally, sickle PMNs at baseline have increased expression of the high-affinity Fc receptor CD64; this receptor is even more pronounced during crisis [28,29].

Gene_expression (expression) of CD64

2) Confidence 0.17 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.74 Pain Relevance 0

g, Sigma, St Luis, Missouri, USA), the human IgG-Fc fragment (Fc control, 2 ?

Gene_expression (fragment) of IgG-Fc

3) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.35

General Comments

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