INT61913

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Context Info
Confidence 0.47
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.04
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B-cells 1
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 229 97.32 Very High Very High Very High
Inflammation 156 96.76 Very High Very High Very High
metalloproteinase 32 94.68 High High
tolerance 23 92.80 High High
cytokine 118 87.48 High High
Paracetamol 1 60.40 Quite High
chemokine 26 55.96 Quite High
transdermal 9 50.00 Quite Low
Inflammatory mediators 10 48.08 Quite Low
rheumatoid arthritis 73 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 237 97.32 Very High Very High Very High
Chlamydia Infection 67 96.96 Very High Very High Very High
INFLAMMATION 171 96.76 Very High Very High Very High
Disease 138 94.72 High High
Immunization 81 94.08 High High
Thrombocytopenic Purpura 2 93.96 High High
Influenza Virus Infection 40 88.24 High High
Infection 133 82.16 Quite High
Weight Loss 3 78.96 Quite High
Bacteremia 18 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It vitro studies have demonstrated that the monoclonal antibody 197 (subclass IgG2a) binds to two distinct epitopes of Fc gamma RI, with the constant domain binding to the Fc-binding portion of the Fc gamma RI and the variable domain binding to a different epitope, resulting in crosslinking and modulation of this receptor.
IgG2a Binding (binding) of
1) Confidence 0.47 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8616043 Disease Relevance 0.49 Pain Relevance 0.06
This has been attributed to the ability IgG2a to interact with all three activating IgG Fc receptors, Fc?
IgG2a Binding (interact) of
2) Confidence 0.23 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.19 Pain Relevance 0
Recently, IgG2a and IgG2b antibody binding common ?
IgG2a Binding (binding) of
3) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.35 Pain Relevance 0.47
production is associated with IgG2a production [37].


IgG2a Binding (associated) of
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.17 Pain Relevance 0
Recently, IgG2a and IgG2b antibody binding common ?
IgG2a Binding (common) of
5) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.35 Pain Relevance 0.49
Addition of anti-collagen IgG2a to the models improved the association with clinical score and bone destruction.
IgG2a Binding (association) of
6) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.25 Pain Relevance 0.41
production is often associated with IgG2a production [46] and may account for the systemic humoral responses against Chlamydia following vaginal challenge.
IgG2a Binding (associated) of associated with chlamydia infection
7) Confidence 0.11 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.84 Pain Relevance 0.12
Rat anti-mouse IgG from Zymed (San Francisco, CA, USA) was used to detect total Ig; the isotype-specific antibodies used to detect IgG1, IgG2a, and IgM were also purchased from Zymed.
IgG2a Binding (detect) of
8) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0
However, these IgG2a can be recognized as immunogenic by B-cells and as PAMP by TLRs, thus inducing autoantibodies to nuclear antigens [56].
IgG2a Binding (recognized) of in B-cells
9) Confidence 0.07 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.11 Pain Relevance 0.09
RIa via OmpA can displace bound IgG2a.
IgG2a Binding (bound) of
10) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0 Pain Relevance 0
RIa can displace the bound IgG2a, which is mediated by OmpA.
IgG2a Binding (bound) of
11) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.30 Pain Relevance 0

General Comments

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