INT6193

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 1996
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.02
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 6
neurons 4
auricles 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 4 100.00 Very High Very High Very High
dexamethasone 16 99.84 Very High Very High Very High
Angina 10 96.80 Very High Very High Very High
Morphine 7 95.24 Very High Very High Very High
Buprenorphine 2 90.60 High High
agonist 6 83.96 Quite High
fortral 1 73.84 Quite High
Clonidine 4 71.00 Quite High
ketamine 1 68.44 Quite High
ischemia 1 56.64 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 11 100.00 Very High Very High Very High
Cv General 3 Under Development 10 96.80 Very High Very High Very High
Coronary Artery Disease 8 91.28 High High
Muscular Spasm 1 61.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that these stimuli can change ANP gene expression in the auricles and that the changes are induced differentially in both auricles.
Regulation (change) of Gene_expression (expression) of ANP in auricles
1) Confidence 0.45 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.15 Pain Relevance 0.34
Our findings demonstrate that androgen exerts its regulatory role by altering plasma ANP levels and the TXA2/PGI2 ratio.
Regulation (altering) of Gene_expression (levels) of plasma ANP in plasma
2) Confidence 0.37 Published 1993 Journal Chin. Med. Sci. J. Section Abstract Doc Link 8032065 Disease Relevance 0.76 Pain Relevance 0.08
[Effects of intravenous anesthetics and analgesics on plasma alpha-rat atrial natriuretic peptide (alpha-rANP) levels in rats].
Regulation ([Effects) of Gene_expression (levels) of atrial natriuretic peptide in plasma associated with natriuresis and analgesic
3) Confidence 0.27 Published 1989 Journal Masui Section Title Doc Link 2533282 Disease Relevance 0.20 Pain Relevance 0.90
Furthermore, in patients with unstable angina, the plasma levels of BNP decreased significantly after the medical treatment (from 39.5 +/- 29.4 pg/ml to 15.8 +/- 11.0 pg/ ml; p < 0.01), whereas the plasma levels of ANP did not change.
Neg (not) Regulation (change) of Gene_expression (levels) of ANP in plasma associated with angina
4) Confidence 0.16 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701849 Disease Relevance 0.81 Pain Relevance 0.70
Plasticity of adrenoceptor responsiveness on irANP secretion and pro-ANP mRNA expression in hypothalamic neuron cultures: modulation by dexamethasone.
Regulation (modulation) of Gene_expression (expression) of irANP in neuron associated with dexamethasone
5) Confidence 0.10 Published 1992 Journal Endocrinology Section Title Doc Link 1324165 Disease Relevance 0.10 Pain Relevance 0.45
We conclude from the above observations that glucocorticoids modulate irANP secretion and pro-ANP mRNA expression in hypothalamic neurons by altering the responsiveness of the cells from alpha 2-AR to that of beta-AR.
Regulation (modulate) of Gene_expression (expression) of irANP in neurons
6) Confidence 0.10 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0 Pain Relevance 0.46

General Comments

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